California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Using Nicotine to Reverse Age-related Auditory Processing Deficits
NCT04971954
Recruiting
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety o... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
09/04/2024
Locations: Hearing and Speech Lab, Irvine, California
Conditions: Auditory Perceptual Impairment, Aging
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Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
NCT04717427
Recruiting
Individuals with Sturge-Weber Syndrome (SWS) sometimes have brain involvement which can result in seizures, stroke-like episodes and neurologic deficits. The purpose of this study is to integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. The research aims are: 1. To integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. 2. Identify plasma and imaging biomarkers sensitive to ex... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/04/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Sturge-Weber Syndrome
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Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer
NCT04397185
Recruiting
This prospective, multicenter, 1:1 randomized, controlled trial is designed to evaluate the safety and effectiveness of the Breast Cancer Locator (BCL) in subjects with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS). Subjects will be randomized to breast conserving surgery (BCS) utilizing either the BCL or wire localization (WL) to guide surgery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: BASS Medical Group, Walnut Creek, California
Conditions: Breast Cancer Female
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The PREDICT Registry:
NCT03448926
Recruiting
This is a prospective, non-interventional (observational) cohort study conducted within the medical network of the participating investigators and institutions. Patients meeting the eligibility criteria (see below) will be eligible for participation and the investigators will obtain written informed consent. A central Institutional Review Board (IRB), WCG IRB, will approve the protocol and each participating institution.
Gender:
FEMALE
Ages:
Between 30 years and 85 years
Trial Updated:
09/03/2024
Locations: Sutter Institute for Medical Research, Sacramento, California
Conditions: DCIS
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Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
NCT03422198
Recruiting
This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells. After completion of cohort 1 (108 participants),... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/03/2024
Locations: Stanford Cancer Center, Palo Alto, California
Conditions: Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Serous Adenocarcinoma, Stage I Uterine Corpus Cancer, Stage IA Uterine Corpus Cancer, Stage IB Uterine Corpus Cancer, Stage II Uterine Corpus Cancer, Uterine Corpus Carcinosarcoma, Uterine Corpus Sarcoma
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North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
NCT01694940
Recruiting
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
Gender:
ALL
Ages:
All
Trial Updated:
09/03/2024
Locations: University of California San Diego, San Diego, California
Conditions: Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes, Deletion and Duplication of Mitochondrial DNA
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Anticoagulation Profile in Pregnant Women Treated with Three Times a Day of Low Molecular Weight Heparin (LMWH)
NCT04861103
Recruiting
Pregnancy is associated with a increased risk of developing blood clots. There is nearly a 5 times greater risk of developing a blood clot in pregnancy. Lovenox is a medication that helps to prevent the body from developing clots. It is safe to use in pregnancy. Previous studies have demonstrated that despite recommendation of Lovenox, to prevent blood clots, the majority of patient's (70 to 90%) did not receive adequate levels of Lovenox at times throughout the day, which likely increases the r... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/02/2024
Locations: University of California Irvine, Orange, California
Conditions: Pregnancy, High Risk, Anticoagulants
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Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
NCT04372953
Recruiting
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies receive some form of mechanical respiratory support to aid breathing. Common to all types of respiratory support is the delivery of a treatment called positive end-expiratory pres... Read More
Gender:
ALL
Ages:
Between 23 weeks and 28 weeks
Trial Updated:
09/02/2024
Locations: Rady Children's at Scripps Memorial Hospital La Jolla/UCSD, San Diego, California
Conditions: Lung Injury, Preterm Birth
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Neuroblastoma Biology Study
NCT01587300
Recruiting
Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma... Read More
Gender:
ALL
Ages:
Between 31 days and 99 years
Trial Updated:
09/01/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Neuroblastoma
Register for Updates
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
NCT06565416
Recruiting
The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN) serving clinics. The investigators also will assess staff perspectives on this implementation as well as a survey to understand clients at these sites who have chronic pain and opioid misuse/opioid use disorder.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Clinic Site A (blinded pending tribal approval), Arcata, California
Conditions: Opioid Use Disorder, Opioid Misuse, Chronic Pain
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Neural and Physiological Correlates of Psychedelic Sub-states
NCT05698511
Recruiting
The main purpose of this study is to gain a better understanding of the distinct mental states and physical reactions that can arise during a psychedelic experience. By repeatedly assessing the same participants in an MRI while under the effects of psilocybin, the investigators want to identify reliable brain and body reactions arising during these psychedelic experiences. It is hoped that this will provide an insight to inspire future research on psilocybin and related psychedelics as well as i... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
08/30/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Psychedelic Experiences, Neuroimaging, Healthy Volunteers
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Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
NCT05417555
Recruiting
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of... Read More
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
08/30/2024
Locations: UCLA Semel Institute for Neuroscience and Behavior, Los Angeles, California
Conditions: Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Register for Updates