California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The APS Phenotyping Study
NCT06521502
Recruiting
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Fresno Community Hospital and Medical Center, Fresno, California
Conditions: ARDS, Sepsis, Pneumonia
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From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices
NCT06352788
Recruiting
This study is designed to support evidence-based practice and optimal care by evaluating how different configurations of two types of carbon fiber custom dynamic orthoses (CDOs) influences outcomes following traumatic lower extremity injury.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/26/2024
Locations: Naval Medical Center San Diego - Clinical Biomechanics Laboratory, San Diego, California
Conditions: Foot Injury
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Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea
NCT06072066
Recruiting
The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
08/26/2024
Locations: Integrative Skin and Research, Sacramento, California
Conditions: Rosacea, Systemic Inflammation
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The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic Dermatitis
NCT05942248
Recruiting
The study is conducted to determine if image-based computer grading can of acne, melasma, rosacea and seborrheic dermatitis correlate well to expert based clinical severity grading.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Integrative Skin and Research, Sacramento, California
Conditions: Acne, Melasma, Rosacea, Seborrheic Dermatitis
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Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers
NCT05722288
Recruiting
This phase II trial studies how well time-restricted eating works in reducing side effects of radiation or chemoradiation side effects when compared to nutritional counseling among patients with prostate, cervical, and rectal cancers. Time-restricted eating, also called short term fasting or intermittent fasting, is an eating plan that alternates between not eating food (fasting) and non-fasting periods. Nutritional counseling involves being asked to follow a healthy, balanced diet that includes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Localized Prostate Carcinoma, Locally Advanced Cervical Carcinoma, Locally Advanced Rectal Carcinoma, Malignant Solid Neoplasm, Recurrent Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage IB Cervical Cancer FIGO 2018, Stage IB2 Cervical Cancer FIGO 2018, Stage II Prostate Cancer AJCC v8, Stage II Rectal Cancer AJCC v8, Stage IIA Cervical Cancer FIGO 2018, Stage IIB Cervical Cancer FIGO 2018, Stage III Prostate Cancer AJCC v8, Stage III Rectal Cancer AJCC v8, Stage IIIA Cervical Cancer FIGO 2018, Stage IIIB Cervical Cancer FIGO 2018, Stage IIIC Cervical Cancer FIGO 2018, Stage IVA Prostate Cancer AJCC v8
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Circulating Biomarkers in the Development of Type 1 Diabetes
NCT05505669
Recruiting
More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens. Insulin is a hormone that helps the body use sugar as a fuel and control blood-sugar levels. People with diabetes have problems making insulin. This is because their insulin-producing beta cells -in the pancreas-are damaged or destroyed. A biomarker is a biological molecule (such as DNA, RNA (the genetic material of cells) o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/26/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Diabetes
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Diaphragmatic Breathing Exercises in Total Knee Arthroplasty Patients
NCT04336579
Recruiting
Rationale: While total knee replacements (TKA) are one of the most commonly performed surgical procedures in the United States, this procedure can also be very painful. Postoperative mobilization and rehabilitation is vital to a patient's recovery, but inadequate pain control can impede patients' progress. Diaphragmatic breathing is an additional non-pharmacological and non-invasive tool with no adverse effects that could aid in recovery. This will serve as a pilot study for a possible larger co... Read More
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
08/25/2024
Locations: Keck Hospital of USC, Los Angeles, California
Conditions: Anesthesia and Analgesia
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Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
NCT03065465
Recruiting
The primary specific aim is to perform a randomized controlled trial (RCT) to compare 30 day rebleed rates and other clinical outcomes of patients with severe, non-variceal upper GI hemorrhage (NVUGIH) - ulcers and Dieulafoy's lesions who are randomized as initial treatment with the new large over-the-scope-clip device for endoscopic hemostasis versus standard endoscopic hemostasis.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/24/2024
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: Upper Gastrointestinal Hemorrhage
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A Study of BRIA-OTS Cellular Immunotherapy in Metastatic Recurrent Breast Cancer
NCT06471673
Recruiting
This is an open-label Phase 1/2a study. Once the safety of the BC1 cell line alone has been demonstrated in Phase 1, in Phase 2, patients will be treated with the Bria-OTS regimen (see below) and a clinically available check point inhibitor (CPI). During the monotherapy phase of Phase 1, one patient will be treated intradermally every 2 weeks for 6 weeks (4 doses) with an initial dose of the BC1 cell line. If this dose is tolerated, the next patient will receive an increased dose of BC1. If onc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Breast Cancer, Breast Tumor, Cancer of Breast, Cancer of the Breast, Malignant Tumor of Breast, Tumors, Breast
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A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors
NCT05830097
Recruiting
The primary objective of this phase I study is to evaluate the safety and potential efficacy and to determine the recommended phase 2 dose (RP2D) of CBP-1019, a bi-specific ligand conjugated drugs in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: TOI Clinical Research LLC, Cerritos, California
Conditions: Cancer, Breast, Cancer, Lung, Cancer of Pancreas, Cancer of Esophagus, Cancer Colorectal
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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Benefits of Endoscopic Bariatric Procedures
NCT05514288
Recruiting
This 12-months long pilot study will include patients undergoing an endoscopic procedure (endoscopic sleeve gastroplasty \[ESG\] or transoral outlet reduction \[TORe\]) as clinically indicated, and subsequent follow up clinic visits for up to one year.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/23/2024
Locations: Liliana Bancila, Los Angeles, California
Conditions: Obesity
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