California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The THINK Study Incidence of Neurotrophic Keratopathy)
Recruiting
The study purpose is to evaluate corneal sensitivity in patients that have Stage 1 Neurotrphic Keratopathy (NK). Identifying patients with Stage 1 NK, may predict those who will in the future require rhNGF for optimal visual performance.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2024
Locations: Harvard Eye Associates, Laguna Beach, California
Conditions: Dry Eye
Correction of Psoriatic T Cell Signatures by Deucravacitinib
Recruiting
This study aims to assess cutaneous and blood immune cell function of patients with psoriasis before and after initiation of treatment with the Tyrosine kinase 2 (TYK2) blocker, deucravacitinib.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/25/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Psoriasis Vulgaris
Molecular Signatures of Cutaneous Dupilumab Response
Recruiting
This study examines the effect of IL4RA blockade with dupilumab on the immune cells of atopic dermatitis skin lesions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Atopic Dermatitis
A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors
Recruiting
This is an open-label, multicenter, Phase 1/2 study evaluating the safety and efficacy of CTX131™ in subjects with relapsed or refractory solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2024
Locations: Research Site 3, Duarte, California
Conditions: Clear Cell Renal Cell Carcinoma, Cervical Carcinoma, Esophageal Carcinoma, Pancreatic Adenocarcinoma, Malignant Pleural Mesothelioma
Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System
Recruiting
The H3 TAR Prosthesis was approved by FDA (P160036) on June 4, 2019. Continued approval of the premarket approval application (PMA) is contingent upon the submission of periodic reports (Annual Report), required under 21 CFR 814.84. In order to provide continued reasonable assurance of the safety and effectiveness of the PMA device, data from this post-approval study must be submitted to FDA in a PMA Post-Approval Study Report per the requirements set forth in the approval.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/24/2024
Locations: Los Angeles Institute of Foot and Ankle Surgery, Mission Hills, California
Conditions: Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
A Study of KER-050 to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes
Recruiting
The purpose of this study is to evaluate the effects of KER-050 on anemia in patients with very low, low or intermediate risk MDS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2024
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Myelodysplastic Syndromes, Cytopenia
Impact of Bluetooth Haptics Device Distraction on Mechanical Pain Thresholds Induced by PinPrick Stimulators
Recruiting
This is a prospective, crossover study of healthy participants evaluating the mechanical pain threshold for weighted pinprick stimuli.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/22/2024
Locations: Lucile Parkard Children's Hospital, Stanford, California
Conditions: Pain, Anxiety
Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma
Recruiting
This study is a Phase III, Randomized, Controlled, Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib versus Physician's Choice in Subjects with Fibroblast Growth Factor Receptor (FGFR)-altered, Chemotherapy- and FGFR Inhibitor-Refractory/Relapsed Cholangiocarcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: UCLA Medical Center, Santa Monica, California
Conditions: Cholangiocarcinoma
The Resilience Clinic Evaluation
Recruiting
Early life adversity can affect children's physical and mental health. The Resilience Clinic is a support program for young children and their caregivers who have been exposed to significant adversity, aiming to prevent the harmful effects of stress and improve child health, behavior, and development while also reducing caregiver stress. This study seeks to evaluate the Resilience Clinic, assessing the intervention's impact on child health, behavior, and development and caregiver stress and ment... Read More
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
06/21/2024
Locations: La Clinica de la Raza, Oakland, California
Conditions: Early Life Adversity, Caregiver Stress
Improving Cognition and Behavior in Pediatric Cancer Survivors Using a Novel Mindful Attention Training
Recruiting
This pilot study will evaluate the cognitive and behavioral outcomes of using a novel, adaptive attention training in pediatric cancer survivors.
Gender:
ALL
Ages:
Between 7 years and 17 years
Trial Updated:
06/21/2024
Locations: Univeristy of California, San Francisco, San Francisco, California
Conditions: Pediatric Cancer
Yttrium-90 Labeled Anti-CD25 Monoclonal Antibody Combined With BEAM Chemotherapy Conditioning for the Treatment of Primary Refractory or Relapsed Hodgkin Lymphoma
Recruiting
This phase II trials studies the effects of yttrium-90 labeled anti-CD25 monoclonal antibody combined with BEAM chemotherapy conditioning in treating patients with Hodgkin lymphoma that does not response to treatment (refractory) or has come back (relapsed). Yttrium-90-labeled anti-CD25 is an antibody (proteins made by the immune system to fight infections) that is attached to a radioactive substance and may kill cancer cells and shrink tumors. Chemotherapy drugs, such as carmustine, etoposide,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Recurrent Hodgkin Lymphoma, Refractory Hodgkin Lymphoma
Shaping Tolerance for Delayed Rewards
Recruiting
Deficits in self-control are of major public health relevance as they contribute to several negative outcomes for both individuals and society. For children, developing self-control is a critically important step toward success in academic settings and social relationships, yet there are few non-pharmacological approaches that have been successful in increasing self-control. We found in our earlier studies that self-control can be increased in preschool-aged children with high impulsivity by usi... Read More
Gender:
ALL
Ages:
Between 3 years and 6 years
Trial Updated:
06/21/2024
Locations: UC Davis MIND Institute, Sacramento, California
Conditions: Impulsivity