California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Recruiting
This is a phase I, open label, plus expansion clinical trial evaluating the safety and tolerability of rHSC-DIPGVax in combination with BALSTILIMAB and ZALIFRELIMAB. rHSC-DIPGVax is an off-the-shelf neo-antigen heat shock protein containing 16 peptides reflecting neo-epitopes found in the majority of DIPG and DMG tumors. Newly diagnosed patients with DIPG and DMG who have completed radiation six to ten weeks prior to enrollment are eligible.
Gender:
ALL
Ages:
Between 12 months and 18 years
Trial Updated:
08/20/2024
Locations: Children's Health Orange County (CHOC), Orange, California
Conditions: Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
CareCOPD - COPD Home Monitoring Study
Recruiting
This is a pilot study to demonstrate early validation of objective home-monitoring of Chronic obstructive pulmonary disease (COPD) patients by combining accurate and relevant patient data of medication and lung function (lung impedance) through patient-facing devices.
Gender:
ALL
Ages:
Between 40 years and 100 years
Trial Updated:
08/20/2024
Locations: Ventura County Medical Center, Ventura, California
Conditions: Chronic Obstructive Pulmonary Disease
Prehabilitation and Rehabilitation in PAD
Recruiting
To determine the effectiveness of pre and post-operative exercise therapy in patients undergoing peripheral artery stenting for peripheral arterial disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: VA Palo Alto Health Care System, Palo Alto, California
Conditions: Peripheral Arterial Disease
Wearable Devices and Biomarkers Project (Healthiomics)
Recruiting
The purpose of this study is to collect clinical data, biological specimens (e.g., blood, tumor, cerebrospinal fluid, urine sample, etc.), and digital health data from patients with tumors, cancer and/or neurological disorders in order to perform research studies that could advance patient care. By collecting these specimens, the investigators plan to create and maintain a biorepository to make data and specimens available to collaborating investigators performing research to discover predictive... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: CureScience Institute, San Diego, California
Conditions: Brain Cancer, Neurological Disorder, Neurological Cancer
Liquid Biopsies in Pediatric Solid Tumors
Recruiting
This study is being done to determine if traces of tumor can be found in the blood before, during, and after patients stop treatment. We will analyze the tumor material to see if it is similar to tumor tissue and if the tumor material in blood is helpful in monitoring the disease.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
08/19/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Pediatric Solid Tumor, Unspecified, Protocol Specific
CureDuchenne LinkĀ®: A Resource for Research
Recruiting
CureDuchenne link is a data hub comprised of integrated biospecimens, clinical data, and self- and/or caregiver-reported information from participants. Anyone over 4 weeks old who has been diagnosed with DMD or BMD or who is a carrier of DMD or BMD can join. Parents or legal guardians can sign up their child(ren).
Gender:
ALL
Ages:
4 weeks and above
Trial Updated:
08/19/2024
Locations: CureDuchenne, Newport Beach, California
Conditions: Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Visuomotor Prosthetic for Paralysis
Recruiting
The investigators objective is to run human clinical trials in which brain activity recorded through a "brain-chip" implanted in the human brain can be used to provide novel communication capabilities to severely paralyzed individuals by allowing direct brain-control of a computer interface. A prospective, longitudinal, single-arm early feasibility study will be used to examine the safety and effectiveness of using a neural communication system to control a simple computer interface and a tablet... Read More
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
08/19/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Quadriplegia
Pituitary Tumor Surveillance: Pathogenic Correlation
Recruiting
The purpose of this study is to observe predictors of pituitary tumor recurrence and markers of persistent disease activity in patients harboring pituitary mass lesions of all types.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Cedars-Sinai Medical Center, Pituitary Center, Los Angeles, California
Conditions: Pituitary Tumor
Tart Cherry Juice as a Dietary Supplement for the Prevention of Paclitaxel-Induced Neuropathy
Recruiting
This is a single institution phase II randomized study evaluating the potential benefits of a supplement, tart cherry juice at high- versus low-doses, to prevent taxane induced peripheral neuropathy in breast and ovarian cancer patients undergoing paclitaxel chemotherapy. Eligible participants enrolled onto the study will be block randomized in a 1:1 allocation to either the tart cherry juice high-dose group (Arm 1) or the tart cherry juice low-dose group (Arm 2).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2024
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Breast Cancer Stage IV, Invasive Breast Cancer, Ovarian Cancer, Ovarian Cancer Stage 1, Ovarian Cancer Stage II, Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Ovarian Cancer Stage IA, Ovarian Cancer Stage IB, Ovarian Cancer Stage IC, Ovarian Cancer Stage 2, Ovarian Cancer Stage 3, Ovarian Cancer Stage IIIb, Ovarian Cancer Stage IIIC, Breast Cancer Stage IIIA, Breast Cancer Invasive, Breast Cancer, Stage IA, Breast Cancer, Stage IB, Breast Cancer Stage IIA, Breast Cancer Stage IIB, Breast Cancer Stage IIIB, Breast Cancer Stage IIIc, Cancer, Breast, Tumors, Breast, Mammary Cancer, Mammary Carcinoma, Breast Carcinoma, Breast Neoplasm, Malignant Breast Neoplasm, Malignant Tumor of Breast, Cancer of Ovary, Ovary Cancer, Ovary Neoplasm
Treatment Optimization of Brain-injured Warfighters
Recruiting
Prescribed sub-symptomatic adaptable exercise treatment (SAET) is a potential solution that promotes recovery needs following a TBI. SAET has been shown to benefit the mind and body in ways that decrease the severity and frequency of mild TBI (mTBI) symptoms. This study aims to validate SAET as an alternative, adaptable treatment or SMs with mTBI that focuses on reducing symptoms, improving mental health, increasing physiological functioning, and ultimately returning to duty. The objective of t... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/16/2024
Locations: Intrepid Spirit Center, Camp Pendleton, California
Conditions: Mild Traumatic Brain Injury
Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping
Recruiting
In this study, a new method will be used to evaluate response to 2 approved biologic therapies, and assess how well each patient responds to each asthma treatment. This study will measure the response to these treatments using genomic and biologic measurements obtained from participants biosamples. By evaluating response to 2 different biologic therapies, this study has the potential to provide an in-depth understanding of the mechanisms underlying severe asthma that will inform and change trea... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/16/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Moderate to Severe Asthma
Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients
Recruiting
This clinical trial studies how well 3-dimensional multi-parametric ultrasound (3D MPUS) imaging works as a decision-support tool for patients with liver tumors undergoing therapy. Continuous and dynamic imaging of patients undergoing therapy is required to monitor early-phase treatment response. 3D-MPUS is an inexpensive and safe method, which may provide complementary quantitative functional (perfusion) and tissue characterization information to anatomical radiological assessment or blood biom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2024
Locations: Stanford University, School of Medicine, Palo Alto, California
Conditions: Liver Cancer, Adult