California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Norris ORIEN Total Cancer Care
Recruiting
This research trial collects biological samples and clinical information to create a repository of data from patients with cancer or a predisposition for cancer. Combining genetic information from biological samples and clinical data may lead to more knowledge about why certain cancers respond to treatment and help create more personalized medicine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Cancer Risk, Malignant Neoplasm
Core Biopsies for Establishing a Breast Tumor Tissue Repository
Recruiting
This research trial establishes a breast tumor tissue repository from core biopsies. Collecting breast tissue from core biopsies may allow doctors to learn more about the biology of breast cancer and to analyze proteins, genes, and other components of tumor cells. It may also allow doctors to conduct future studies to help understand how breast cancer grows and how it responds to different types of therapy. This will help doctors develop better breast cancer therapies and better tests to help ma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: USC Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Breast Cancer
Fabry Disease Registry & Pregnancy Sub-registry
Recruiting
The Fabry Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of treatment status. No experimental intervention is involved; patients in the Registry undergo clinical assessments and receive care as determined by the patient's treating physician. The primary objectives of the Registry are: * To enhance the understanding of the variability, progression, and natural history of F... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/07/2025
Locations: University of California at Irvine- Site Number : 840036, Irvine, California
Conditions: Fabry Disease
Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
Recruiting
The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition. The main question it aims to answer is: Does radiation therapy alter the expression of tissue factor and other molecules in cervical cancer over time? Participants already scheduled for radiation therapy for cervical cancer as part of their regular medical care will provide blood and biopsies of cervical cancer or of the upper portion of the vagi... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: University of California San Diego, La Jolla, California
Conditions: Cervical Cancer
Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults With Moderate or Severe Asthma
Recruiting
This study is trying to identify the right dose of a long-acting medicine called WIN378 for people with moderate or severe asthma. WIN378 blocks the action of a protein called TSLP which causes inflammation in the lung and may contribute to your asthma control and symptoms. The study will test how doses of WIN378 are handled by your body (pharmacokinetics) and assess the safety of the medicine and will assess markers of asthma inflammation in your breath and in your blood, lung function and asth... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/06/2025
Locations: WB Contracted Clinical Research Site, Los Angeles, California
Conditions: Asthma (Diagnosis)
NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia
Recruiting
This study will evaluate the long-term safety of NBI-1117568 in adults with schizophrenia.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/06/2025
Locations: Neurocrine Clinical Site, Pico Rivera, California
Conditions: Schizophrenia
HOPE Intervention for Fitness
Recruiting
We will test the HOPE intervention on changing behavior of people to exercise more (take more steps each day).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: UC Irvine, Irvine, California
Conditions: Diabetes Mellitus Type 2
A Research Study on How a Dose of NNC0662-0419 Works in Japanese, Chinese and Non-Asian Participants Living With Overweight or Obesity
Recruiting
The study is testing the new medicine NNC0662-0419 in people living with overweight or obesity. The purpose of the study is to look into the amount of the new medicine NNC0662-0419 in participants blood after one dose. And also look into how safe and how well the study medicine is tolerated in people living with overweight or obesity. NNC0662-0419 is a new medicine which cannot be prescribed by doctors. NNC0662-0419 is currently being tested in humans and the dose participants will receive has b... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/06/2025
Locations: Altasciences Clinical LA, Inc., Cypress, California
Conditions: Overweight, Obesity
Developing a Digital Aid to Improve ICD Decisions
Recruiting
Advanced heart failure, affecting 7 million Americans, has multiple causes and results in greatly increased risk of disability and death. A major problem is sudden cardiac death, when the damaged heart develops an abnormal pattern of electrical conduction that can result in cessation of heart activity. While placement of an Implantable Cardioverter-Defibrillator (ICD) in a patient's chest can help prevent sudden cardiac death, these devices have several important downsides. This protocol focuses... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/06/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Heart Failure and Reduced Ejection Fraction
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels
Recruiting
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending doses of AZD4954 in healthy participants with or without elevated Lipoprotein(a) (Lp\[a\]) levels.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/06/2025
Locations: Research Site, Glendale, California
Conditions: Healthy Participants
A Study to Assess the Safety and Efficacy of Oral LPCN 1154A in Women With Severe PPD
Recruiting
The purpose of this research study is to test the study drug, LPCN 1154A, as a possible treatment for postpartum depression (PPD). The trial aims to determine: * If LPCN 1154A reduces depressive symptoms in subjects with severe PPD * How well LPCN 1154A is tolerated and what side effects it may cause * If LPCN 1154A reduces anxiety symptoms in subjects with severe PPD
Gender:
FEMALE
Ages:
Between 15 years and 45 years
Trial Updated:
08/06/2025
Locations: Advanced Research Center, Anahiem, California
Conditions: Depression, Postpartum, Depression, Post-Partum, Postpartum Depression (PPD), Post-Natal Depression, Peripartum Depression, Postnatal Depression
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
Recruiting
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during res... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2025
Locations: USC Keck, Los Angeles, California
Conditions: Migraine