Colorado is currently home to 1917 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
CGX1321 in Subjects With Advanced Solid Tumors and CGX1321 With Pembrolizumab or Encorafenib + Cetuximab in Subjects With Advanced GI Tumors (Keynote 596)
NCT02675946
Recruiting
This is a multicenter, open-label study conducted in two phases: Phase 1 consisting of a CGX1321 Single Agent Dose Escalation Phase in solid tumors, CGX1321 Single Agent Dose Expansion Phase in GI tumors and Roll-over Cohort of CGX1321 and pembrolizumab in subjects who have progressed on single agent CGX1321 and Phase 1b consisting of CGX1321 in combination with pembrolizumab in colorectal tumors and CGX1321 in combination with encorafenib + cetuximab in BRAFV600E mutated colorectal tumors. Both... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: Sarah Cannon Research Institute at HealthONE, Denver, Colorado
Conditions: Solid Tumors, GI Cancer
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Improving Immunization Rates in Transplant Candidates Through the Use of a Health Information Technology Tool
NCT04336735
Recruiting
Vaccine preventable infections are a serious complication following pediatric solid organ transplant. Immunizations are a minimally invasive and cost-effective was to reduce these infections. Despite the importance of pre-transplant vaccination, the majority of pediatric solid organ transplant recipients are not up-to-date on age-appropriate immunizations at the time of transplant. The goal of this study is to pilot a novel health information technology immunization tool to improve immunization... Read More
Gender:
All
Ages:
17 years and above
Trial Updated:
01/10/2022
Locations: Childrens Hospital Colorado, Aurora, Colorado
Conditions: Transplantation Infection, Vaccination
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ASYMPTOMATIC AND PRE-SYMPTOMATIC TRANSMISSION OF SARS-COV-2 IN A COMMUNITY CONGREGANT SETTING
NCT05145803
Recruiting
The overall aim of this study is to measure how transmission of COVID-19 occurs in communities - including the role of super spreaders and/or identifying conditions that may increase transmission risk, with a focus on congregant situations. In order to identify how presence of symptoms and behavior affects the transmissibility of the virus, we will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using polyvinyl alcohol (PVA) test strips embedded in face masks (Face M... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/01/2021
Locations: Anschutz Medical Campus, Aurora, Colorado
Conditions: COVID-19, SARS-CoV2 Infection
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An Outcomes Study Utilizing Allomend(R) HD for Superior Capsular Reconstruction
NCT04615117
Recruiting
Rotator cuff tears can usually be repaired with excellent results, however some chronic, extensive rotator cuff tears are not reparable secondary to tendon retraction with inelasticity, muscle atrophy, and fatty infiltration. Arthroscopic superior capsular reconstruction (SCR) utilizing allograft or autograft tissue has been shown to restore superior glenohumeral stability and function of the shoulder joint in patients with irreparable rotator cuff tears. Grafts utilized for SCR have included fa... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/04/2021
Locations: Western Orthopaedics Education and Research Foundation, Denver, Colorado
Conditions: Rotator Cuff Tear or Rupture, Not Specified as Traumatic
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Addressing Anxiety and Stress for Healthier Eating in Teens
NCT05038033
Recruiting
Project ASSET will explore the preliminary efficacy of interpersonal therapy, when compared with cognitive behavioral therapy, for reducing anxiety symptoms, preventing excess weight gain, and reducing cardio-metabolic risk in adolescent girls with above-average weight and elevated anxiety. As a pilot for a larger multi-site study, this trial will also test multi-site feasibility, acceptability, and intervention fidelity.
Gender:
Female
Ages:
Between 12 years and 17 years
Trial Updated:
08/31/2021
Locations: Colorado State University, Fort Collins, Colorado
Conditions: Obesity, Overweight, Anxiety, Mental Disorders, Body Weight, Eating Behavior, Feeding and Eating Disorders
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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
All
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: B-cell Acute Lymphoblastic Leukemia
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Effects of Aromatherapy on Patient Satisfaction With Surgical Abortion at Less Than 10 Weeks Gestation
NCT04969900
Recruiting
The investigators propose a single-site, double-blinded, placebo-controlled clinical trial of lavender aromatherapy versus placebo for patient satisfaction in adult women having a surgical abortion before 10 weeks and 0 days gestation. The investigators will evaluate whether lavender aromatherapy is an effective adjunct therapy for patient satisfaction during first trimester surgical abortion. The investigators will measure satisfaction using the Iowa Satisfaction with Anesthesia Scale (ISAS). T... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
08/17/2021
Locations: Comprehensive Women's Health Center, Denver, Colorado
Conditions: Surgical Abortion, Patient Satisfaction, Anesthesia, Pain
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Multi-Center Study to Evaluate the Efficacy and Safety of Sildenafil Cream (3.6%) in Premenopausal Patients With Female Sexual Arousal Disorder
NCT04948151
Recruiting
This study is looking to minimize side effects, while maintaining and potentially improving the therapeutic benefit to patients suffering from Female Sexual Arousal Disorder by providing a topical preparation of Sildenafil locally to the vulvar-vaginal tissue.
Gender:
Female
Ages:
21 years and above
Trial Updated:
06/24/2021
Locations: Downtown Women's Healthcare, Denver, Colorado
Conditions: Female Sexual Arousal Disorder
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Measuring Omalizumab Responses Using Real-world Evidence (MORRE) Study
NCT04724278
Recruiting
Develop new real-world evidence indicators of worsening and improving asthma. Scientists will measure (1) steps per day, (2) duration and intensity of exercise per day, (3) sleep duration and the number of awakenings per night using Fitbit activity trackers. Scientists will measure asthma symptoms using a once-monthly custom survey delivered to participant smartphones via Twilio. Scientists may measure rescue medication use and adherence to maintenance medications using digital inhaler devices.... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/21/2021
Locations: National Jewish Health, Denver, Colorado
Conditions: Asthma
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Home Based Infusions for Ocrelizumab
NCT04650321
Recruiting
The goal is to assess the safety and effectiveness of home ocrelizumab infusion.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
06/08/2021
Locations: Amerita, Centennial, Colorado
Conditions: Multiple Sclerosis
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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
NCT04916210
Recruiting
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/03/2021
Locations: University of Colorado, Denver, Colorado
Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment
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Objective Measures of Nerve Integrity, Posture, Gait and Blood Flow, After Nerve Decompression
NCT01735903
Recruiting
The purpose of this study is to measure the effect of nerve decompression on the recovery of the treated nerves. To obtain objective data during surgery of the treated nerves' via electrical signals and muscle power when stimulated. Also, to monitor muscle strength, balance/gait and blood flow in the lower extremity before and after surgery.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
02/15/2021
Locations: Anderson Podiatry Center, Neuropathy Testing Center of Colorado, Fort Collins, Colorado
Conditions: Diabetic Peripheral Neuropathy
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