There are currently 281 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
A Precision Medicine Approach to Target Engagement for Emotion Regulation
NCT05651295
Recruiting
The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Emotional Regulation, Depression, Anxiety, Borderline Personality Disorder, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Eating Disorders
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Behavioral Activation Teletherapy to Increase Physical Activity
NCT04990401
Recruiting
This is a pilot study of acceptability, feasibility, and preliminary efficacy of a brief, 10-session Behavioral Activation intervention delivered via teletherapy to increase physical activity and treat depressive symptoms.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
09/23/2023
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode
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Digital Single Session Intervention for Youth Mental Health
NCT05449002
Recruiting
The aim of this study is to test the effectiveness of a single-session, digital intervention teaching the principle of practicing the opposite, when administered to youths on the waitlist for psychotherapy, with usual waitlist procedures as a control condition.
Gender:
All
Ages:
Between 9 years and 17 years
Trial Updated:
09/21/2023
Locations: Riley Child Psychiatry and Behavioral Sciences Clinic, Indianapolis, Indiana +4 locations
Conditions: Anxiety, Depression, Conduct Disorder, Stress
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A Neurobiological Model of Anhedonia
NCT05629520
Recruiting
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
09/21/2023
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Anhedonia, Depression
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MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression
NCT05220202
Recruiting
The proposed study seeks to evaluate effectiveness, implementation processes, and cost of MOTIVATE among older Veterans with chronic musculoskeletal (MSK) pain and comorbid depressive symptoms.
Gender:
All
Ages:
Between 60 years and 99 years
Trial Updated:
09/21/2023
Locations: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas +1 locations
Conditions: Chronic Back Pain, Depression, Aging, Musculoskeletal Pain
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Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
NCT05682677
Recruiting
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to s... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
09/19/2023
Locations: UCSD, La Jolla, California
Conditions: Depression, Mild Traumatic Brain Injury, Concussion, Brain
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Neuromodulation for Comorbid Hoarding Disorder and Depression
NCT05985356
Recruiting
The primary goal of this study is to evaluate whether intermittent theta burst stimulation (iTBS) is effective for treating depression in people who have depression and chronic hoarding disorder (HD). The study will also evaluate whether this treatment can improve HD symptoms, cognitive performance, and brain region connectivity. The study team will investigate how the treatment works for depression, as well as other factors that can enhance or hinder treatment, such as pre-treatment level of de... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
09/13/2023
Locations: UC San Diego, La Jolla, California
Conditions: Hoarding Disorder, Hoarding, Depression
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The PATHway Study: Primary Care Based Depression Prevention in Adolescents
NCT05203198
Recruiting
Prevention of depressive disorders has become a key priority for the NIMH, but the investigators have no widely available public health strategy to reduce morbidity and mortality. To address this need, the investigators developed and evaluated the primary care based-technology "behavioral vaccine," Competent Adulthood Transition with Cognitive-Behavioral Humanistic and Interpersonal Therapy (CATCH-IT). The investigators will engage N=4 health systems representative of the United States health ca... Read More
Gender:
All
Ages:
Between 13 years and 18 years
Trial Updated:
09/13/2023
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois +5 locations
Conditions: Depression, Mental Disorder in Adolescence
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A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers
NCT05044546
Recruiting
This study evaluates a mood management and health and wellness smoking cessation intervention for depressed pregnant smokers during and after birth. This study may help pregnant smokers who are experiencing depression quit smoking and stay smoke-free after their babies are born.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Depression, Tobacco Use Disorder
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Storytelling and Mindfulness for Graduate Student Wellbeing
NCT05826860
Recruiting
The purpose of this study is to evaluate an intervention for improving Science, Technology, Engineering, and Math (STEM) graduate student wellbeing. Participants will be recruited from the University of Wisconsin-Madison graduate student body. Data will be collected from participants for up to 2 years, and the investigators anticipate that the study will last for 4 years.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/29/2023
Locations: Wisconsin Institute for Discovery, Madison, Wisconsin
Conditions: Depression, Anxiety, Burnout, Student
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The Families and Middle School Success Project
NCT05400564
Recruiting
The purpose of the proposed research is to conduct an efficacy trial of the Family Check-Up (FCU) Online to prevent emotional and behavioral disorders among middle-school students at-risk for disability during the transition back to school after the COVID-19 pandemic. Mental health and behavior problems are at epidemic proportions as a result of the COVID-19 pandemic, with the highest rates in adolescents and children with disabilities. We propose to evaluate the efficacy of the FCU Online, a sc... Read More
Gender:
All
Ages:
All
Trial Updated:
08/24/2023
Locations: University of Oregon Prevention Science Institute, Portland, Oregon
Conditions: Parenting, Parent-Child Relations, Self-regulation, Problem Behavior in School, School Adjustment, Depression
Register for Updates
Testing FIRST in Youth Outpatient Psychotherapy
NCT04725721
Recruiting
The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions.
Gender:
All
Ages:
Between 7 years and 15 years
Trial Updated:
08/23/2023
Locations: Harvard University, Cambridge, Massachusetts +1 locations
Conditions: Anxiety, Depression, Trauma, Behavior Problem
Register for Updates