There are currently 254 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
taVNS or TMS or Both for Depression
NCT05725239
Recruiting
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/02/2024
Locations: Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina
Conditions: Depression
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Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
NCT04276259
Recruiting
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors \[RPE\]) to antidepressant responses (Aim1) by experimentally manipulating expected values using transcranial magnetic stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using pharmacological approaches (Aim 3).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/01/2024
Locations: Bellefield Tower, Pittsburgh, Pennsylvania
Conditions: Major Depressive Disorder, Depression
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Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults
NCT06060860
Recruiting
Autistic adults are at a greater risk for mental health problems compared to the general population, with 50% meeting criteria for a co-occurring psychiatric condition. Depression and anxiety are the most common of these conditions among autistic adults, contributing to long-term detrimental effects on health, day-to-day functioning, and quality of life. This study will conduct the first large-scale head-to-head comparison of the two most widely studied mental health interventions for autistic a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina +1 locations
Conditions: Autism Spectrum Disorder, Depression, Anxiety
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Mindfulness Engaged Neurostimulation for Depression
NCT06399406
Recruiting
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermitten... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/20/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder
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Telehealth Behavioral Activation for Teens
NCT06273995
Recruiting
Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to increase an individual's engagement in valued and enjoyable activities (e.g., socializing with family and friends, exercising, participating in a hobby) in order to improve depressive symptoms. Research has shown that behavioral activation is an effective intervention for depr... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
06/20/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
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The Nuestros Días ("Our Days") Study
NCT06475534
Recruiting
The goal of this observational study is to understand how contextual, individual-level, and cultural factors influence the daily and long-term well-being of caregivers of relatives with memory problems or dementia. The study focuses on caregivers from the Hispanic and Latino community. The main questions it aims to answer are: * What daily factors increase (i.e., risk factors) or decrease (i.e., protective factors) the daily odds of depression and anxiety symptoms reported by caregivers? * How... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/20/2024
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Caregiver Burden, Well-Being, Psychological, Stress, Psychological, Depression, Anxiety
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Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
NCT06261463
Recruiting
The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social strengthening multiple family group intervention that is designed to respond to multi-level needs of refugee families. Results of the trial will contribute to the emerging evidence base on family-base... Read More
Gender:
ALL
Ages:
Between 12 years and 55 years
Trial Updated:
06/14/2024
Locations: University of Illinios Chicago, Chicago, Illinois
Conditions: Depression, Anxiety, PTSD, Family Dynamics, Social Functioning, Family Support, Family Relations
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A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
NCT05081596
Recruiting
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
06/11/2024
Locations: Weill Cornell Medicine, White Plains, New York
Conditions: Depression, Pain, Cognitive Impairment
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Depression & Insulin Sensitivity in Adolescents
NCT03263351
Recruiting
There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups. This group of girls also is at heightened risk for depression, and depression and T2D are linked. Depressive symptoms are a risk factor for worsening of insulin sensitivity, one if the major precursors to T2D. In preliminary studies, the investigators found that a brief cognitive-behavioral therapy group decreased depressive symptoms and prevented worsening of... Read More
Gender:
FEMALE
Ages:
Between 12 years and 17 years
Trial Updated:
06/06/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance, Depression, Adolescent Obesity
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Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
NCT05555875
Recruiting
This study is a clinical trial that evaluates what drives patient engagement and tests the impact of two strategies-automated motivational push messaging and coach support-to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/05/2024
Locations: Jessica Morrow Lipschitz, Boston, Massachusetts
Conditions: Depression, Anxiety Disorders
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Randomized Controlled Trial of a Behavioral Training App
NCT06447909
Recruiting
The investigators propose addressing and evaluating the efficacy of a behavioral, contingency management app by conducting a randomized controlled trial (RCT) that will evaluate the app compared to a placebo app control group. Participants will be randomly assigned to immediate intervention using the treatment condition or to a placebo app condition. Participants will not know which condition they are assigned to until after the study completion; they will also not know that they are using the t... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
06/03/2024
Locations: New York University, New York, New York
Conditions: Behavior, Child, Disruptive Behavior, Executive Dysfunction, Attention-deficit, Anxiety, Depression, Stress
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Evaluation of the H.O.O.V.E.S. Healing Intensives Program
NCT06300255
Recruiting
The aim of this study is to measure the impact of these H.O.O.V.E.S. healing intensives on Veteran participants using several psychological instruments. The investigators are planning to administer the demographic questionnaires and psychological instruments to Veteran participants before the healing intensives. Psychological instruments will be administered immediately pre-intervention, pre- and post-session for each session, post-intervention, 90, 120 and 360 days post-intervention. The primar... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
05/24/2024
Locations: George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah
Conditions: Anxiety, PTSD, Depression
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