There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Effect of Kava on Anxiety and Stress in Cancer Survivors
NCT06213298
Recruiting
This is a pilot, two-arm, randomized, blinded, placebo-controlled cross-over clinical trial to study the safety and effect of 14 days of kava on anxiety and physiologic stress in survivors of cancer and its treatment. Participants will be randomized to take either kava first or placebo first. Kava 75 mg or placebo will be taken three time daily (TID) for 14 days (Period 1), followed by a washout period of 14-28 days. Thereafter, the participant will take either placebo or kava TID for 14 days (P... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Masonic Cancer Center, Minneapolis, Minnesota
Conditions: Kava, Anxiety, Stress, Cancer, Depression, Sleep
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PCORI Comparative Effectiveness Study-Esketamine (Spravato) Vs. Ketamine-Equivalence Study
NCT06713616
Recruiting
The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for use in the treatment of treatment-resistant depression (TRD) and Esketamine (Spravato®), taken as a nasal spray which has received FDA approval for use in the treatment of treatment-resistant depression (TRD) in the treatment of patients with treatment-resistant depression (TRD). The study will look a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Mood Institute, Milford, Connecticut +3 locations
Conditions: Depression
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Family Acceptance Project Online (Pilot RCT)
NCT06839859
Recruiting
Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic). A major factor that leads to these challenges is family rejection (family behaviors and reactions that minimize, deny, ridicule and attempt to prevent or change a child's sexual orientation, gender identity and gender expression). Racial and ethnic minority youth experience the highest rates of family rejection and related health risks. The F... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
03/11/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: LGBTQ, Racial Disparities, Family Relationships, Minority Stress, Depression, Anxiety, Drug Use, Teen Dating Violence, Sexual Risk Reduction
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Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
NCT03973268
Recruiting
Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work. A drug that blocks these receptors might affect how it works. Objective: To see if the antidepressant response of ketamine is linked to AMPA receptors. Eligibility: Adults ages 18-70 with major depression disorder without psychotic features Design: Participants will be screened under protocol 01... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/10/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression, Major Depressive Disorder, Major Depression
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SilverCloud as a School-Based Intervention for Vulnerable Youth
NCT06004414
Recruiting
The goal of this study is to test the efficacy and feasibility of a clinician-guided, app-based cognitive behavioral therapy (CBT) program, SilverCloud, as a school-based mental health intervention for vulnerable youth. An open trial of SilverCloud will be conducted to determine preliminary efficacy in this sample and inform program refinements by collecting outcome self-report assessments and conducting interviews on feasibility and acceptability. After the program and its implementation strate... Read More
Gender:
ALL
Ages:
Between 13 years and 22 years
Trial Updated:
03/10/2025
Locations: Rutgers University, New Brunswick, New Jersey +2 locations
Conditions: Depression, Anxiety
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Mobile Cognitive Behavioral Therapy for Stroke
NCT06689878
Recruiting
This study aims to assess the feasibility and acceptability of "MAYA", a mobile cognitive behavioral therapy app for anxiety and mood disorders, in adults who have had a stroke.
Gender:
ALL
Ages:
Between 40 years and 79 years
Trial Updated:
03/07/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Anxiety, Stroke, Depression
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Neurobiology of Suicide
NCT02543983
Recruiting
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when someone has thought about or attempted suicide. Eligibility: Group 1: Adults ages 18 70 who have thought about or attempted suicide recently Group 2: Adults ages 18 70 who have thought about or... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/06/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers, Depression
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Chronobiological Basis of Menopausal Depression: Correcting Misaligned Circadian Rhythms with Sleep and Light Interventions
NCT06678880
Recruiting
The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of m... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of California San Diego Hillcrest Medical Center, San Diego, California
Conditions: Depression, Depression During the Menopausal Transition, Menopausal Depression
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The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program
NCT06652503
Recruiting
The purpose of this research study is to provide a free 6-week, online psychological coaching program to NSU undergraduate students to help with anxiety, depression, and stress, while improving quality of life and healthy coping skills.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Nova Southeastern University, Fort Lauderdale, Florida
Conditions: Anxiety, Depression, Stress, Wellbeing, Quality of Life
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Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
NCT06263660
Recruiting
This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression. In this double-blind randomized placebo-controlled trial, 75 individuals with a Patient Health Questionnaire (PHQ-9) scale score ≥ 10 (MDD) will be enrolled to participate in an 8-week treatment study to obtain 60 completers. Participants will be randomized with a 1-1 ratio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/03/2025
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Depression
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Mental Health App for Cancer Survivors Study
NCT06472726
Recruiting
The goal of this clinical trial is to adapt a mental health digital app to treat depression among head and neck cancer patients and survivors. Participants will download and use the digital mental health app for a 6-week period, and will complete related surveys.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/03/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Head and Neck Cancer, Head and Neck Cancers, Depression
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Potential Benefits of Parent Child Interaction Therapy (PCIT)
NCT06827951
Recruiting
The goal of this study is to explore possible benefits of Parent-Child Interaction Therapy (PCIT). The main goals of the study are: * To investigate whether pre-survey measures of autonomic reactivity relate to the overall functioning of participants. * To examine the effects of PCIT To identify individual characteristics that influence the effects of PCIT. Participants will: * complete 5 online surveys (1x pre-PCIT, 3x during PCIT, and 1x post-PCIT) * complete the PCIT program
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/28/2025
Locations: UF Health Child Psychiatry, Gainesville, Florida +1 locations
Conditions: Autonomic Dysregulation, Anxiety, Depression, Parent-Child Relations
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