There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
NCT06019377
Recruiting
This study will deploy a scalable secondary prevention program that leverages existing foster youth transition services to improve mental health functioning and service use before and after exiting foster care. Our short-term objective is to remotely test a group intervention called Stronger Youth Networks and Coping (SYNC) that targets cognitive schemas influencing stress responses, including mental health help-seeking and service engagement, among foster youth with behavioral health risk. SYNC... Read More
Gender:
ALL
Ages:
Between 16 years and 20 years
Trial Updated:
02/25/2025
Locations: Portland State University, Portland, Oregon
Conditions: Adolescent Behavior, Psychosocial Functioning, Coping Behavior, Help-Seeking Behavior, Utilization, Health Care, Depression, Anxiety, Stress Disorders, Post-Traumatic, Emotion Regulation, Child Welfare
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Transdiagnostic Cognitive Biomarkers
NCT04864080
Recruiting
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depres... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pain, Depression
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Digital InteGrated Behavioral TreatmeNt for Comorbid ObesITy and DeprEssion Among Racial and Ethnic Adults Age 50 and Older
NCT06636058
Recruiting
The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program video-based program for weight loss, among racial and ethnic minorities with comorbid depression and obesity. The study aims include: * Determine the efficacy of the vCare intervention at 6 months. Primary outcomes are weight and depression symptom checklist 20-item (SCL-20) sc... Read More
Gender:
ALL
Ages:
Between 50 years and 74 years
Trial Updated:
02/25/2025
Locations: Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois +1 locations
Conditions: Obesity, Depression
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Well-being Training for Adolescent Depressive Symptoms (TeenWell Study)
NCT06626425
Recruiting
This study is being done to see if the Healthy Minds Program app helps adolescents with elevated depressive symptoms. Up to 200 participants will be on study for 20 weeks.
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
02/24/2025
Locations: Center for Healthy Minds, University of Wisconsin Madison, Madison, Wisconsin
Conditions: Depression
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Examining the Effects of Estradiol on Neural and Molecular Response to Reward
NCT05282277
Recruiting
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Gender:
FEMALE
Ages:
Between 45 years and 55 years
Trial Updated:
02/24/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Depression, Psychosis, Anhedonia
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Cognitive and Affective Processes Online
NCT05736471
Recruiting
This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and discriminant validity of cognitive and affective constructs such as those introduced to understand mental disorders, and (4) sensitivity (and correspondence) to individual differences. For these tests to be useful in studying clinical conditions, they must show adequate relia... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/23/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Depression
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Digital Support for Mental Health Intervention in Patients With Inflammatory Bowel Disease
NCT06575660
Recruiting
This is a small, exploratory study that will investigate using an artificial intelligence (AI) and virtual reality (VR), digital wellness application (app) to deliver a mental health support session in outpatient and hospitalized patients with inflammatory bowel disease (IBD) and co-existing symptoms of mild to moderate anxiety or depression. The purpose of this study is to explore if a mental health support session using the app is feasible, safe, and acceptable to IBD patients and whether it... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Inflammatory Bowel Diseases, Anxiety, Depression, Ulcerative Colitis, Crohn Disease
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Cannabis, Linked Emotions, and Adolescent Risk Study
NCT06576076
Recruiting
The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of scalable, individualized, accessible, and affordable interventions aimed to reduce depression and suicide risk among adolescents.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/21/2025
Locations: Massachusetts General Hopsital, Boston, Massachusetts
Conditions: Cannabis Use, Depression, Suicidal Ideation, Adolescent Behavior
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Stress and Pain in People Living With HIV
NCT06784908
Recruiting
This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.
Gender:
ALL
Ages:
Between 18 years and 68 years
Trial Updated:
02/19/2025
Locations: The Yale Stress Center, New Haven, Connecticut
Conditions: HIV, Depression, Cannabis Use Disorder, Stress, Pain
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Sleep to Reduce Incident Depression Effectively in Peripartum
NCT06430333
Recruiting
Perinatal depression (PND) is the most common complication in pregnancy and postpartum, which increases risk for adverse perinatal outcomes such as preterm birth, maternal suicidal thoughts, and impaired mother-infant bonding. Insomnia often precedes PND cases and may serve as an entry point for interventions preventing PND. The proposed project is a large-scale clinical trial to test the effectiveness of a mindfulness-based sleep program designed for pregnant women to improve sleep and alleviat... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/19/2025
Locations: Henry Ford Medical Center, Novi, Michigan
Conditions: Insomnia, Depression
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Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story
NCT05809115
Recruiting
The main goal of this research is to help families who are experiencing food insecurity (FI) and help mothers with depression. The next goal is to provide other resources to help with household needs like rent or utility assistance, health insurance, anxiety, and depression. Our theory is that helping with food insecurity, household needs, and emotional health will help children and families.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Texas Children's Hospital, Houston, Texas
Conditions: Food Insecurity, Depression, Anxiety
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Conversations With Caregivers About Health and Appearance
NCT06843200
Recruiting
This clinical trial is evaluating the effects of a 2-hour, small group discussion with parents and caregivers of adolescents in Oregon. We will evaluate whether parents'/caregivers' experience reductions in their disordered eating symptoms, mood symptoms, and parent-child relationship quality, relative to parent/caregiver participants in the wait list control. We will also evaluate whether the children of these parents/caregivers experience improvements in their disordered eating and mood sympto... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
02/18/2025
Locations: University of Oregon, Eugene, Oregon
Conditions: Disordered Eating Behaviors, Depression, Feeding Behaviors, Parent-Child Relations
Register for Updates