Massachusetts is currently home to 3366 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
Recruiting
The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeons. Patients will be treated following one of three study arms: 1) a craniotomy where the resection boundaries for motor or language functions will be identified by the "awake" mapping technique (awake craniotomy, AC); 2) a craniotomy where the resection boundaries for motor functions will be identif... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/05/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Glioblastoma
Trauma Informed Guilt Reduction Therapy
Recruiting
The goal of this project is to determine if a 6-session psychotherapy intervention will help Veterans feel less deployment-related guilt and less distress related to their guilt. Half of the participants will receive the guilt focused intervention and half will receive a supportive intervention. A supplemental pilot study added in FY2021 will examine the intervention for pandemic-related guilt events.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2022
Locations: National Center for PTSD, Boston, Massachusetts
Conditions: Guilt, Shame, Post-traumatic Stress Disorders
Developing a Test for the Detection of Ovarian Cancer
Recruiting
The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples of the wash and the blood will be taken before surgery. After surgery, doctors will determine whether the participant had ovarian cancer or a benign disease of the ovaries. The tests of the washings and the blood will be examined to see how much the participants with ovarian cancer can be separated... Read More
Gender:
Female
Ages:
30 years and above
Trial Updated:
04/29/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Ovarian Neoplasms, Ovarian Epithelial Carcinoma, Fallopian Tube Neoplasms, High Grade Ovarian Serous Adenocarcinoma, Stage I Ovarian Cancer, Stage II Ovarian Cancer, Stage III Ovarian Cancer AJCC v8, Stage IIIA Ovarian Cancer AJCC v8, Stage IIIA1 Ovarian Cancer AJCC v8, Stage IIIA2 Ovarian Cancer AJCC v8, Stage IIIB Ovarian Cancer AJCC v8, Stage IIIC Ovarian Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IVA Ovarian Cancer AJCC v8, Stage IVB Ovarian Cancer AJCC v8
The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
Recruiting
Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient popula... Read More
Gender:
All
Ages:
All
Trial Updated:
04/29/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sudden Cardiac Death
Machine Learning Sepsis Alert Notification Using Clinical Data
Recruiting
Machine learning is a powerful method to create clinical decision support (CDS) tools, when training labels reflect the desired alert behavior. In our Phase I work for this project, we developed HindSight, an encoding software that was designed to examine discharged patients' electronic health records (EHRs), identify clinicians' sepsis treatment decisions and patient outcomes, and pass those labeled outcomes and treatment decisions to an online algorithm for retraining of our machine-learning-b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/27/2022
Locations: Baystate Health, Springfield, Massachusetts
Conditions: Sepsis, Severe Sepsis, Septic Shock
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)
Recruiting
The PROTECT-ICD trial is a physician-led, multi-centre randomised controlled trial targeting prevention of sudden cardiac death in patients who have poor cardiac function following a myocardial infarct (MI). The trial aims to assess the role of electrophysiology study (EPS) in guiding implantable cardioverter-defibrillator (ICD) implantation, in patients early following MI (first 40 days). The secondary aim is to assess the utility of cardiac MRI (CMR) in analysing cardiac function and viability... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/27/2022
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Sudden Cardiac Death
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
Recruiting
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, physical function and quality of life when compared with placebo in women with chronic back pain treated with opioids who have low testosterone.
Gender:
Female
Ages:
60 years and above
Trial Updated:
04/26/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pain, Opioid Use, Androgen Deficiency
Bronchial NIR Image-guided Resection
Recruiting
This is a clinical trial to evaluate the use of peritumoral injection of near-infrared dye indocyanine green to identify lung lesions and sentinel lymph nodes. The primary purpose is to determine if the use of ICG injected via navigational bronchoscopy, CT-guided or transthoracic allows us to identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for analysis to improve the ability to detect tumor in this node and to... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sentinel Lymph Node
Neural Correlates of Stress and Perceived Control in Adolescent Depression
Recruiting
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechan... Read More
Gender:
Female
Ages:
Between 14 years and 18 years
Trial Updated:
04/21/2022
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Major Depressive Disorder
Near-Infrared Perfusion During Minimally Invasive Thoracic Surgery Download
Recruiting
This will be a prospective, (NSR), single-center feasibility study of the Olympus VE2 NIR Imaging System to assess perfusion using NIR during minimally invasive esophagectomy and pulmonary segmentectomy. The aims of the study are: 1. To utilize NIR intraoperative imaging with the Olympus VE2 NIR Imaging System to: i. Characterize gastric conduit perfusion during esophagectomy and, ii. Identify segmental anatomy during sublobar pulmonary resection (segmentectomy) after intraoperative, intravenou... Read More
Gender:
All
Ages:
All
Trial Updated:
04/20/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Neoplasms, Esophageal Lesion
A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma
Recruiting
CyberKnife Based Radiosurgery is a way to deliver large doses of radiation very accurately to a tumor. The ability of this technology to minimize radiation dose to organs adjacent to the target tumor allows a high dose to be delivered to the tumor, thus potentially increasing the efficacy of radiation treatment. Currently, radiosurgery is commonly used for brain metastases, Stage I lung cancer, spine tumors, and localized prostate cancer. The purpose of this protocol is to evaluate the role of R... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2022
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Renal Cell Carcinoma
Molecular and Genetic Analysis of Lung Cancer
Recruiting
Investigators use a genome-wide approach within a case-control design to identify SNPs that show evidence of association with lung cancer risk and survival.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/14/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer