Massachusetts is currently home to 3310 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)
NCT03540771
Recruiting
This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
04/05/2022
Locations: VA Boston, Boston, Massachusetts
Conditions: End Stage Liver Disease
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Measuring Physiology to Determine if Pre-panic Attack Detection is Possible
NCT03360578
Recruiting
Participants will be asked to wear a physiological monitoring device for 1 week and record when panic events occur. Once the device is returned, the data will be downloaded and analyzed.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/05/2022
Locations: Medical Psychology Center, Beverly, Massachusetts
Conditions: Panic Disorder
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Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial
NCT05230225
Recruiting
The DETECT AS Trial is a randomized clinical trial and quality improvement initiative that seeks to investigate the impact of electronic provider notification of severe aortic stenosis (AS) on its management, on the utilization of aortic valve replacement (AVR), and on ethnic and racial disparities in AVR utilization. After the investigators identify patients in whom echocardiography shows severe aortic stenosis, defined by an aortic valve area (AVA) <1.0cm2, the ordering provider of the echoca... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis
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GI Complications in Cancer Immunotherapy Patients
NCT02784366
Recruiting
The purpose of this study is to establish a prospective observational cohort of cancer immunotherapy patients with GI side effects in order to identify biomarkers that predict GI complications due to treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Malignant Melanoma
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Parents Advancing Toddler Health
NCT04824989
Recruiting
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention.We will enroll 500 low-income toddlers with co-morbid sleep and behavior probl... Read More
Gender:
All
Ages:
Between 18 months and 48 months
Trial Updated:
04/01/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Sleep Problem, Behavior, Child
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COVID-19 Symptom Tracker
NCT04331509
Recruiting
The viral Covid-19 outbreak is now considered a pandemic according to the World Health Organisation (WHO). A free monitoring app 'COVID-19 Symptom Tracker' has been developed to record and monitor the symptoms of the COVID-19 coronavirus infection; tracking in real time how the disease progresses. The app also records how measures aimed at controlling the pandemic including self-isolation and distancing are affecting the mental health and well-being of participants. The data from the study will... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/30/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: COVID-19
Register for Updates
Genetics of QT Prolongation With Antiarrhythmics
NCT02439658
Recruiting
To assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in patients being loaded with dofetilide or sotalol.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Long QT Syndrome, Drug Toxicity
Register for Updates
Study of Safety and Efficacy of ANG-3070 in Chronic Kidney Disease
NCT04939116
Recruiting
The major objective is to demonstrate the safety and efficacy of ANG-3070 in patients with primary glomerular disease and persistent proteinuria.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Glomerular Disease, Proteinuria
Register for Updates
Dasatinib In Waldenström Macroglobulinemia
NCT04115059
Recruiting
This is Phase I pilot, single center study designed to explore the safety of Dasatinib in symptomatic Waldenström Macroglobulinemia participants who are progressing on ibrutinib therapy with BTK Cys481 or PLCG2 mutations
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2022
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Waldenstrom Macroglobulinemia, DASATINIB
Register for Updates
Neuroimaging Study of Dexmedetomidine-Induced Analgesia
NCT04656470
Recruiting
Neuroimaging data will be collected for patients that are given low doses of dexmedetomidine in order to understand its analgesic effects.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
03/18/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Analgesia, Anesthesia
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Revisiting the Mechanism of the Anti-inflammatory Effect of Colchicine
NCT04355585
Recruiting
We are doing this research study to better understand the mechanism of action of colchicine, a drug commonly prescribed for gout. Precisely, we aim to evaluate the effect of colchicine on a specific protein (GDF15) blood levels at different timepoints after its administration. This research study will compare GDF15 blood levels after the administration of colchicine or placebo. The placebo looks exactly like colchicine but contains no active drug. During this study, participants may get a place... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
03/14/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Colchicine Mechanism of Action
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A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception
NCT03882073
Recruiting
The hypothesis of this research protocol is that the investigators will be able to redesign the manner in which upper limb amputations are performed so as to enable volitional control of next generation prosthetic devices and restore sensation and proprioception to the amputated limb. The investigators will test this hypothesis by performing modified above elbow or below elbow amputations in ten intervention patients, and compare their outcomes to ten control patients who have undergone traditio... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/12/2022
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Amputation
Register for Updates