Massachusetts is currently home to 3310 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Identification/Characterization of Changes in Microscopic Colitis
NCT03063957
Recruiting
The goal of this study is to establish a prospective observational cohort of adult patients with microscopic colitis and collect clinical information and specimens over the course of their treatment. This information will be used in order to establish a patient registry with detailed clinical data and a specimen repository for future research as well as to specifically identify genetic and molecular characteristics associated with microscopic colitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/31/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Colitis, Microscopic
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taVNS Treatment for Fibromyalgia
NCT04777500
Recruiting
In this research study we want to learn more about if transcutaneous electrical nerve stimulation (TENS), a safe electrical stimulation tool, can relieve Fibromyalgia pain. A total of 60 subjects with Fibromyalgia will be enrolled in this study at Massachusetts General Hospital, Charlestown Navy Yard campus.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
08/30/2021
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Fibromyalgia
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Blood Transfusion by Boston MedFlight Registry
NCT04610814
Recruiting
The primary aim of this observational registry is to study the outcomes of patients with hemorrhagic shock transported by Boston MedFlight receiving blood products during transport.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/30/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hemorrhagic Shock
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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
All
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts
Conditions: B-cell Acute Lymphoblastic Leukemia
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Optimization of Diet Before Surgery (OptiSurg)
NCT04627688
Recruiting
The overarching goal of this project is to assess whether a controlled short-term Time restricted feeding (TRF) intervention leads to metabolic benefits, improves recovery after vascular surgery and that TRF is safe. Participants suffering from intermittent claudication (Fontaine stage II peripheral artery disease, PAD) will be randomly assigned to a 2-week TRF or active control dietary advices before open surgical revascularization. Prior to the surgery, the investigators will assess the eating... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Surgery, Time Restricted Feeding
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Novel Assessment of Synaptic Density in Progressive MS
NCT04634994
Recruiting
The investigators propose to use the novel SV2a-PET ligand, [F-18]SDM-8 to assess synaptic density in progressive MS (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)) as compared to relapsing-remitting multiple sclerosis (RRMS) patients and healthy controls, given its improved imaging characteristics and potential for large scale applicability. The specific aims of the study are: Aim 1: To compare the cortical and subcortical grey mat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
07/20/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Relapsing Multiple Sclerosis, Multiple Sclerosis
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Phytochemicals on "Metabolic Aging" in Older Overweight Adults
NCT04919876
Recruiting
Aging is a complex and inevitable biological process that is associated with numerous chronic health conditions and the development and progression of diseases. It is manifested partly by a progressive decline in fitness and an increase in death. The key to healthy aging is a healthy lifestyle, including eating a variety of healthy foods and frequently participating in physical activities. Supplements made from widely consumed plant products have the potential for promoting healthy aging. Howeve... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
07/19/2021
Locations: Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts
Conditions: Mitochondrial Functions
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Apple Heart & Movement Study
NCT04198194
Recruiting
This study will look for factors that affect heart health and potentially cause deterioration in mobility or heart function. Participant's Apple Watch and iPhone can help researchers gain a better understanding of potential early warning signs. This can lead to new interventions and products that will help millions lead longer, healthier, and more active lives.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Prevention
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Multi-Center Study to Evaluate the Efficacy and Safety of Sildenafil Cream (3.6%) in Premenopausal Patients With Female Sexual Arousal Disorder
NCT04948151
Recruiting
This study is looking to minimize side effects, while maintaining and potentially improving the therapeutic benefit to patients suffering from Female Sexual Arousal Disorder by providing a topical preparation of Sildenafil locally to the vulvar-vaginal tissue.
Gender:
Female
Ages:
21 years and above
Trial Updated:
06/24/2021
Locations: Boston Clinical Trials, Boston, Massachusetts
Conditions: Female Sexual Arousal Disorder
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Pilot Study of a Multimodal Prehabilitation Pancreatic Cancer Program
NCT03865875
Recruiting
The purpose of this research is to explore the benefits of an exercise and nutrition program during total neoadjuvant therapy (TNT) in preparation for surgery for participants that have pancreatic ductal adenocarcinoma (PDAC)
Gender:
All
Ages:
18 years and above
Trial Updated:
05/13/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pancreatic Ductal Adenocarcinoma
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Sleep Profiles in REM Sleep Behavior Disorder
NCT04886076
Recruiting
Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder in which you act out dreams during REM sleep. Sleep disturbances are very common in RBD, where they negatively impact patients' quality of life and safety. One of the known causes of sleep disturbance is the impairment of the "circadian rhythm", or the human sleep/wake cycle. The purpose of this study is to examine the role of disruption of the circadian rhythm in the development of RBD.
Gender:
All
Ages:
40 years and above
Trial Updated:
05/12/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Rapid Eye Movement Sleep Behavior Disorder
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The Role of Naps and Overnight Sleep on Cognitive Learning in Preschoolers
NCT04758663
Recruiting
The goal of this research is to understand the role of sleep on memory function in early childhood. Specifically, we seek to examine how promoted naps vs. promoted waking in habitual and non-habitual napping children may impact overnight sleep physiology and subsequent memory consolidation.
Gender:
All
Ages:
Between 33 months and 71 months
Trial Updated:
05/12/2021
Locations: University of Massachusetts, Amherst, Massachusetts
Conditions: Sleep
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