Massachusetts is currently home to 3366 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
BMI-Associated Labor Induction: A Prospective Trial
NCT04035382
Recruiting
The primary objective of this study is to determine if planned induction of labor at 39 weeks for nulliparous with pre-pregnancy BMI ≥ 35 kg/m2 reduces the incidence of cesarean section compared to expectant management
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/11/2022
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Labor Induction
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Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
NCT05324813
Recruiting
The overarching goal of this online study is to compare the efficacy of six (weekly) sessions of Domain-Specific Episodic Future Thinking (DS-EFT) relative an active control condition on improving the ability to value future rewards and reducing cannabis use (grams and days of use), tobacco use, and alcohol use among.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/10/2022
Locations: AHP Corporate Office, Sudbury, Massachusetts
Conditions: Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
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Paresthesia Free Spinal Cord Stimulation (PF-SCS)
NCT03670147
Recruiting
The goal is to document efficacy of PF-SCS therapy in a blinded fashion and better understand how SCS therapy works in the clinical setting. Overall the investigators hope to improve patient care and selection of candidates who have the best potential for effective pain relief from an expensive and invasive therapy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/06/2022
Locations: MGH Center for Translational Pain Research, Boston, Massachusetts
Conditions: SCS, Chronic Pain
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Vagus Nerve Stimulation and Stress Reduction Training for Migraine
NCT03592329
Recruiting
This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/06/2022
Locations: Anthinoula A. Martinos Center, Charlestown, Massachusetts
Conditions: Migraine
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Biomarkers to Predict and Monitor Response to Infliximab
NCT04655729
Recruiting
The aim of the study is to generate novel minimally-invasive serum protein signatures and biomarkers in children and adolescents with Crohn's Disease (CD) that correlate with and can predict and monitor patients who will have a prolonged response to Infliximab so that personalized medicine can be applied to patients with CD.
Gender:
All
Ages:
Between 3 years and 20 years
Trial Updated:
04/05/2022
Locations: MassGeneral for Children, Boston, Massachusetts
Conditions: Crohn Disease
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Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)
NCT03540771
Recruiting
This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
04/05/2022
Locations: VA Boston, Boston, Massachusetts
Conditions: End Stage Liver Disease
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Measuring Physiology to Determine if Pre-panic Attack Detection is Possible
NCT03360578
Recruiting
Participants will be asked to wear a physiological monitoring device for 1 week and record when panic events occur. Once the device is returned, the data will be downloaded and analyzed.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/05/2022
Locations: Medical Psychology Center, Beverly, Massachusetts
Conditions: Panic Disorder
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Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial
NCT05230225
Recruiting
The DETECT AS Trial is a randomized clinical trial and quality improvement initiative that seeks to investigate the impact of electronic provider notification of severe aortic stenosis (AS) on its management, on the utilization of aortic valve replacement (AVR), and on ethnic and racial disparities in AVR utilization. After the investigators identify patients in whom echocardiography shows severe aortic stenosis, defined by an aortic valve area (AVA) <1.0cm2, the ordering provider of the echoca... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis
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GI Complications in Cancer Immunotherapy Patients
NCT02784366
Recruiting
The purpose of this study is to establish a prospective observational cohort of cancer immunotherapy patients with GI side effects in order to identify biomarkers that predict GI complications due to treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Malignant Melanoma
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Parents Advancing Toddler Health
NCT04824989
Recruiting
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention.We will enroll 500 low-income toddlers with co-morbid sleep and behavior probl... Read More
Gender:
All
Ages:
Between 18 months and 48 months
Trial Updated:
04/01/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Sleep Problem, Behavior, Child
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The Accuracy Of A Novel Platelet Activity Assay In Humans On Antiplatelet Agents: Pharmacodynamics And Comparison With Light Transmission Aggregometry
NCT04822363
Recruiting
The purpose of this study is to test a novel diagnostic immunoassay of platelet function and compare it to the current gold standard platelet function assay by testing the response to aspirin and clopidogrel in a group of healthy volunteers and severely obese individuals and comparing the accuracy of the two tests. The secondary goals will be to evaluate the pharmacodynamic parameters of the antiplatelet agents across the two testing modalities and refine the cutoffs used for the novel assay.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/31/2022
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Platelet Activation Testing Before/After Anti-platelet Therapy, Healthy
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COVID-19 Symptom Tracker
NCT04331509
Recruiting
The viral Covid-19 outbreak is now considered a pandemic according to the World Health Organisation (WHO). A free monitoring app 'COVID-19 Symptom Tracker' has been developed to record and monitor the symptoms of the COVID-19 coronavirus infectionÍž tracking in real time how the disease progresses. The app also records how measures aimed at controlling the pandemic including self-isolation and distancing are affecting the mental health and well-being of participants. The data from the study will... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/30/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: COVID-19
Register for Updates