Massachusetts is currently home to 3366 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea
NCT04575740
Recruiting
Obstructive sleep apnea (OSA) is a highly prevalent disorder with adverse neurocognitive and cardio-metabolic outcomes. Continuous positive airway pressure (CPAP) is the gold standard therapeutic option to treat airway obstructions during sleep and thus, prevent its adverse cardiovascular and neurocognitive outcomes. Previous clinical trials, however, have largely failed to show a consistent impact of CPAP on these health outcomes. One of the main limitations of these trials may be the inadequa... Read More
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
12/13/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Sleep Apnea
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Robotic Exosuit Augmented Locomotion (REAL)
NCT04818424
Recruiting
Previous studies of the exosuit technology have culminated in strong evidence for the gait-restorative effects of soft robotic exosuits for patients post-stroke by means of substitution for lost function. The present study builds on this work by suggesting that an exosuit's immediate gait-restorative effects can be leveraged during high intensity gait training to produce long-lasting gait restoration. Current gait training efforts are focused on either quality or intensity. They focus on gait qu... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
12/08/2021
Locations: Harvard University, Boston, Massachusetts
Conditions: Stroke
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Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms
NCT04819074
Recruiting
Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and informed consent, and potentially even modification of certain modifiable risk factors. The aim of the Prediction of adverse events after microsurgery for intracranial unruptured aneurysms (PRAEMIUM) study is therefore to develop and externally validate a clinically app... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Aneurysm, Brain
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FDG an Myocardial Infarction: The PIAF Trial
NCT05138718
Recruiting
In order to define distinct and reliable arterial 18Fluorodeoxyglucose (FDG) thresholds identifying patients at risk for cardiovascular events, patients with a history of myocardial infarction will be included in this international multicenter trial. Non-enhanced whole-body FDG PET/CT will be performed in all patients and the arterial FDG uptake in the carotid arteries as well as the aorta will be quantified by calculating different uptake parameters. In addition, FDG uptake in hematopoietic tis... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
11/30/2021
Locations: Massachusetts General Hospital, Havard Medical School, Boston, Massachusetts
Conditions: History of Myocardial Infarction
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LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers
NCT04899973
Recruiting
The proposed Phase 2 project will involve the further development and evaluation of LEAD IT!, which is a tablet-based app designed to enable persons with dementia to lead activities for their peers (i.e., other persons with dementia). The study will examine the clinical outcomes of long-term use of the app by both Resident Leaders (RLs) and Resident Players (RPs). The Specific Aims of the proposed Phase 2 project are to: Develop improved Beta 1 and Beta 2 Versions of LEAD IT! with sufficient c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2021
Locations: Hearthstone Alzheimer Care, Winchester, Massachusetts
Conditions: Dementia, Alzheimer Disease
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Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
NCT05145959
Recruiting
The investigators' aim is to study the effects of mechanical expression of meibomian glands on eyelid disease, ocular surface health in the subacute phase of SJS/TEN. The primary outcome is to use meibomian gland imaging to assess the health and caliber of the meibomian glands of both lower eyelids, between the treated and non-treated eyes before and after the intervention. Monitoring of outcomes will be measured by comparing the results of meibography at the initial visit and at the 6-month fo... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/23/2021
Locations: Massachusetts Eye and Ear Hospital, Boston, Massachusetts
Conditions: Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses, Ocular Surface Disease, Meibomitis, Meibomian Gland Dysfunction, Dry Eye
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Investigation of Brain Plasticity in Autism Spectrum Disorders
NCT04706364
Recruiting
Individuals with autism spectrum disorders (ASD) commonly experience variances in tactile behaviors, such as hypersensitivity to light touch stimuli, altered texture discrimination, and hyporesponsivity to pain. Researchers aim to investigate the somatosensory sensitivity and sensorimotor integration utilizing novel, objective behavioral assays and TMS. The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disor... Read More
Gender:
All
Ages:
Between 6 years and 18 years
Trial Updated:
11/04/2021
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Autism Spectrum Disorder
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The HALT Biomarker Study
NCT04552275
Recruiting
The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatment of HALT with systemic anticoagulation; and to identify circulating proteins that predict the occurrence of HALT. The study population will be adult patients undergoing transfemoral transcatheter aor... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
11/02/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis, Hypo-attenuated Leaflet Thickening, Bioprosthetic Valve Degeneration
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A Phase I Study of Niraparib Administered Concurrently With Postoperative RT in Triple Negative Breast Cancer Patients
NCT03945721
Recruiting
This research study involves Niraparib as a possible treatment for triple negative breast cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/27/2021
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Triple Negative Breast Cancer, Residual Disease
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Data Collection of Heart Rate and Blood Pressure
NCT05095753
Recruiting
The purpose of the study is data collection for building and validating the algorithms for analytics of vital signs using wearable earphones (MindMics device).
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
10/22/2021
Locations: MindMics, Inc., Cambridge, Massachusetts
Conditions: Healthy People
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Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
NCT04735263
Recruiting
interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
Gender:
All
Ages:
Between 50 years and 85 years
Trial Updated:
10/07/2021
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Age-related Macular Degeneration
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Prospective, Randomized, Controlled Agreement and Reproducibility Clinical Study
NCT05026658
Recruiting
Visual acuity is the relative ability of the eye to resolve detail that is usually expressed as the reciprocal of the minimum angular separation in minutes of two lines just resolvable as separate and that forms in the average human eye an angle of one minute. Visibly Inc. has developed a method for determining a patient's visual acuity electronically via a web-based software system that can be self-administered wherever convenient. This method provides an efficient alternative for people to ha... Read More
Gender:
All
Ages:
Between 22 years and 40 years
Trial Updated:
09/17/2021
Locations: Andover Eye Associates, Andover, Massachusetts
Conditions: Digital Acuity Product
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