Cerebrotendinous Xanthomatosis (CTX) Prevalence Study
NCT02638220
Recruiting
This is an observational, multicenter study to determine the prevalence of Cerebrotendinous Xanthomatosis (CTX) in patient populations diagnosed with early-onset idiopathic bilateral cataracts. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were seen at each study site prior to that site's initiation, or by entering care at the site while the site is participating in the trial.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
11/07/2018
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Cerebrotendinous Xanthomatosis (CTX)
Register for Updates
Effects of Prebiotic Supplementation and Exercise on Inflammatory Markers, Vascular Function and Cognition in CKD
NCT03689569
Recruiting
The study is primarily designed to examine the effect of 16 weeks of prebiotic supplementation (resistant starch)and moderate intensity aerobic training on markers of inflammation in stage 3-4 patients with chronic kidney disease.
Gender:
All
Ages:
Between 30 years and 75 years
Trial Updated:
10/04/2018
Locations: Springfield College, Springfield, Massachusetts
Conditions: Chronic Kidney Diseases
Register for Updates
Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC)
NCT03447860
Recruiting
The Primary objective of the study is to evaluate the effectiveness of mindfulness based caregiver intervention, Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC) compared to an established cognitive behavior therapy based dementia caregiver intervention, Resources for Enhancing Alzheimer's Caregiver Health (REACH) in improving caregiver burden and quality of life of care recipient.
Gender:
All
Ages:
All
Trial Updated:
09/10/2018
Locations: VA Boston Health Care system, Brockton, Massachusetts
Conditions: Dementia
Register for Updates
TARGET Intracranial Aneurysm Coiling Registry
NCT01748903
Recruiting
The purpose of this prospective registry is to collect real world, post-marketing data on the use of Stryker Target® 360,Target® 2D, and 2nd generation Target® Nano coils for the embolization of ruptured or unruptured intracranial saccular aneurysms. Up to 300 patients (150 in the TARGET 360°/Helical arm and 150 in the New NANO arm) presenting with intracranial aneurysms suitable for coil embolization will be enrolled at up to 20 sites. A post hoc analysis comparing Target® 360° and Target® 2D c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2018
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: Intracranial Aneurysms
Register for Updates
Advanced MRI Applications Development
NCT01847833
Recruiting
The goals of this study are to: To improve upon and develop new innovative magnetic resonance imaging techniques that refine image quality and enhance performance. Improvements in these areas will have positive implications for medical diagnosis and treatment. To correlate MRI images with underlying disease pathophysiology in order to ensure that imaging accurately reflects the disease process.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2018
Locations: MGH, Boston, Massachusetts
Conditions: Brain Tumors
Register for Updates
International PFO Consortium
NCT00859885
Recruiting
The prevalence of patent foramen ovale (PFO) is about 25% in the general population and approximately 40% in patients who have ischemic stroke of unknown cause (cryptogenic stroke). Given the large number of asymptomatic patients, no primary prevention is currently recommended. On the contrary, secondary prevention is very important. Prospective studies have shown that antithrombotic treatment (ATT) with aspirin or warfarin appears to negate the risk of recurrent stroke associated with a PFO. Pa... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/11/2017
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Stroke, Transient Ischemic Attack
Register for Updates
Intensive Therapy Archival Research
NCT03271398
Recruiting
This is an internal treatment evaluation to determine whether eye movement desensitization and reprocessing (EMDR) or progressive counting (PC) should become the preferred trauma treatment for the investigator's clients. The investigator is using routine/existing in-house measures and case files to track symptom reduction, trauma treatment time, rate of treatment switching (from EMDR to PC or vice versa), and rate of trauma treatment refusal. This is retrospective as well as prospective archival... Read More
Gender:
All
Ages:
All
Trial Updated:
09/04/2017
Locations: Trauma Institute & Child Trauma Institute, Northampton, Massachusetts
Conditions: Trauma, Psychological
Register for Updates
Pulsatile GnRH in Anovulatory Infertility
NCT00383656
Recruiting
The purpose of this study is to explore the effects of synthetic gonadotropin-releasing hormone (GnRH) upon the pituitary and ovaries of women with infertility. Women diagnosed with GnRH deficiency, hypothalamic amenorrhea or acquired hypogonadic hypogonadism, will participate in this study. It is hoped that administration of GnRH will lead to proper stimulation of the pituitary gland and to normal ovulation and menstruation. **WE ARE CURRENTLY RECRUITING ONLY WOMEN WITH A DIAGNOSIS OF IDIOPATH... Read More
Gender:
Female
Ages:
Between 16 years and 45 years
Trial Updated:
07/09/2017
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypogonadotropic Hypogonadism, Amenorrhea, Kallmann's Syndrome
Register for Updates
Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
NCT00673842
Recruiting
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior 5 years, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/07/2016
Locations: Beth Israel Deaconess, Boston, Massachusetts
Conditions: Myocardial Infarction, Sudden Death
Register for Updates
Barrett's Esophagus Patient Registry
NCT01776346
Recruiting
The ultimate goal of the Barrett's Esophagus Patient Registry is to help develop more effective targeted screening strategies and treatment options for Barrett's esophagus and esophageal adenocarcinoma (EAC). We plan to do by developing a registry that will serve as a platform. Examples of analyses could include identifying genetic determinants and biomarkers that predict BE, progression of BE to EAC, as well as the response to therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/23/2013
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Gastroesophageal Reflux
Register for Updates