Characterization of Fetal Lung With Quantitative Ultrasound
NCT06722365
Recruiting
The purpose of the study is to show if it's possible to use a special kind of ultrasound called backscatter quantitative ultrasound (bQUS) to check on a baby's lungs when the mother is 36 weeks pregnant. 12 participants will be on study for a single 30 minute ultrasound between 32 and 36 weeks of pregnancy.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/20/2025
Locations: Meriter Hospital, Madison, Wisconsin
Conditions: Respiratory Complication, Fetal Lung Imaging
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Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
NCT04588545
Recruiting
The purpose of this study is to find out if radiation therapy followed by intrathecal trastuzumab and pertuzumab is safe and will result in improved survival in HER2 positive breast cancer which has metastasized to the leptomeninges.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Moffitt Cancer Center, Tampa, Florida +1 locations
Conditions: HER2-positive Breast Cancer, Leptomeningeal Metastasis, Leptomeningeal Disease
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Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)
NCT05853575
Recruiting
This study will evaluate the efficacy of two dosing regimens of adagrasib (600 mg BID versus 400 mg BID) in patients with NSCLC with KRAS G12C mutation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Providence Medical Foundation - Research, Santa Rosa, California +119 locations
Conditions: Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Lung
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Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
NCT05933681
Recruiting
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/20/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Parkinson Disease
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Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
NCT04685616
Recruiting
RADAR is a multicentre, international, randomised, open-label phase III clinical trial composed of 2 trials running in parallel. Trial 1 will be led and sponsored by University College London (UCL) and conducted in Europe and Australia/New Zealand. Trial 2 will be led by the Canadian Cancer Trials Group (CCTG) and conducted in North America, with CCTG the regulatory sponsor in Canada, and University of Miami the regulatory sponsor and IND holder in the US. Datasets from Trial 1 and Trial 2 will... Read More
Gender:
ALL
Ages:
Between 16 years and 69 years
Trial Updated:
08/20/2025
Locations: Stanford University - (Stanford Cancer Institute), Stanford, California +61 locations
Conditions: Hodgkin Lymphoma
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Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)
NCT04944979
Recruiting
The purpose of this study is to assess efficacy, safety and pharmacokinetics of Kedrion Immunoglobulin 10% (KIg10) in pediatric patients with Primary Immunodeficiency Disease (PID).
Gender:
ALL
Ages:
Between 2 years and 16 years
Trial Updated:
08/20/2025
Locations: Velocity Clinical Research - MedPharmics - Lafayette, Chula Vista, California +20 locations
Conditions: Primary Immunodeficiency Disease
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Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer
NCT06930755
Recruiting
This is a multicenter, open-label Phase Ia/b study on the safety and efficacy of the combination of NMS-03305293 and topotecan in patients with recurrent ovarian cancer, with dose-limiting toxicity (DLT) escalation. The aim of this study is to determine the safety and tolerability, as well as to evaluate the anti-tumor efficacy and pharmacokinetics of NMS-03305293 in combination with topotecan.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Tennessee Oncology, Nashville, Tennessee
Conditions: Ovarian Cancer
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A Study of Breast Cancer Risk Factors and Outcomes of People in Florida
NCT06780176
Recruiting
The purpose of this study is to understand why different people have different risks and outcomes for breast cancer and non-breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: University of California, Los Angeles (Specimen Analysis only), Los Angeles, California +2 locations
Conditions: Breast Cancer, Breast Neoplasms, Breast Diseases
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A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer
NCT04958239
Recruiting
This study is open to adults with advanced cancer (solid tumors) and people with advanced head and neck cancer. The study has 2 parts. The purpose of Part 1 of this study is to find the highest dose of a medicine called BI 765179 that people with solid tumors can tolerate when taken alone or together with a medicine called ezabenlimab. The goal of Part 2 is to find out whether BI 765179 in combination with a medicine called pembrolizumab helps people with advanced head and neck cancer. In Part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: University of Arizona, Tucson, Arizona +49 locations
Conditions: Neoplasms
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A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)
NCT07121959
Recruiting
The goal of this study is to learn how belzutifan (MK-6482) affects the levels of metformin in a healthy person's body over time. Researchers will study levels of metformin in the blood and urine in healthy volunteers after taking metformin alone (Period 1) and metformin with belzutifan (Period 2).
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/20/2025
Locations: Celerion (0001), Tempe, Arizona
Conditions: Healthy
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A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.
NCT05322577
Recruiting
The main objectives of this study are to evaluate the safety and tolerability of bemarituzumab in combination with other anti-cancer therapies, and to evaluate the efficacy of bemarituzumab in combination with S-1 and oxaliplatin (SOX) and nivolumab as assessed by objective response.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/20/2025
Locations: Northport Veterans Affairs Medical Center, Northport, New York +41 locations
Conditions: Gastric Cancer, Gastroesophageal Junction Cancer
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Genomically Guided Radiation Therapy in the Management of Triple Negative Breast Cancer
NCT05528133
Recruiting
The purpose of the study is to determine the feasibility of genomically guided radiation therapy (RT) in people with triple negative (HER2 negative, hormone receptor negative) breast cancer undergoing breast conservation therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Morton Plant Hospital - Baycare Health System, Clearwater, Florida +1 locations
Conditions: Triple Negative Breast Cancer
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