What is Fibromyalgia?


ibromyalgia is a common musculoskeletal condition. It causes pervasive muscle pain and tenderness that can appear alongside fatigue and cognitive or mood changes. Pain and spasms may occur virtually anywhere in the body.

The origins of fibromyalgia are not fully understood. Experts believe fibromyalgia amplifies painful sensations by changing how the brain processes them. Once it develops, fibromyalgia generally persists for life, although symptoms may change.

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What Conditions is Fibromyalgia Associated With?

Anyone can develop fibromyalgia, although about 70%-90% of sufferers are women. It is often experienced in the wake of a physical trauma, surgery, infection, or substantial psychological stress. However, it does not always have a triggering event.

Mental health symptoms are commonly experienced alongside fibromyalgia pain. This includes characteristic “fibro fog” that makes it difficult to focus and pay attention. Many fibromyalgia patients also suffer anxiety and depression.

Fibromyalgia Lifestyle Changes and Recovery

There is no cure for fibromyalgia. Fibromyalgia treatment focuses on managing symptoms and maintaining quality of life. Fibromyalgia symptoms do not necessarily worsen with age, but they tend to be pervasive. Fibromyalgia flare-ups can be debilitating.

Fibromyalgia patients are generally treated with pain-relieving medication customized to their symptoms. Many patients will begin with an OTC pain reliever like Tylenol and then progress to a prescription pain medication when symptoms require. Some patients respond to anti-seizure drugs.

Fibromyalgia can lead to anxiety or depression. Proactive mental health care helps. Traditional talk therapy is one way of addressing a sense of mourning or other negative feelings that arise from fibromyalgia. Therapy can talk place in a group setting or one-on-one.

Many people with fibromyalgia also experience sleep disturbances such as insomnia – making it harder to fall asleep or stay asleep. This may make them vulnerable to other health complications. Fibromyalgia treatment often includes a number of measures intended to raise sleep quality. Many states allow the use of medical cannabis for fibromyalgia.

What Research Currently Exists Around Fibromyalgia?

Fibromyalgia research has not yet discovered why some people develop the disorder. However, fibromyalgia clinical studies have been launched to understand the connection between this disorder and several others that often occur at the same time.

Some common co-morbid disorders include:

  • Irritable Bowel Syndrome (IBS)
  • Frequent headaches, including migraine
  • Tempromandibular joint disorders (TMJ)
  • Interstitial cystitis

Physicians believe that more effective fibromyalgia treatments may be possible if links between these disorders are studied in greater detail. Likewise, fibromyalgia clinical resources exploring genetic disease factors are still under development.

Why Are Further Fibromyalgia Clinical Trials Important?

The ultimate goal of fibromyalgia medical research is to understand the disease’s underlying causes and create fibromyalgia medication that can arrest or cure it. A fibromyalgia cure is still many years away, but it could improve quality of life for millions of Americans. At the same time, new fibromyalgia diagnosis tools could identify those in need of early treatment.

Current Fibromyalgia Clinical Trials

Fibromyalgia medical research is being actively performed throughout the U.S. and around the world. It is not unusual to see new fibromyalgia clinical trials every few months. This is the current list of fibromyalgia clinical trials archived at ClinicalTrials.gov. To add a fibromyalgia clinical trial to our site, simply contact our team.

  • A Study to Evaluate Lu AG06466 in Participants With Fibromyalgia
    on July 23, 2021 at 4:00 pm

    Condition:   FibromyalgiaInterventions:   Drug: Lu AG06466;   Drug: PlaceboSponsor:   H. Lundbeck A/SRecruiting

  • Proprioceptive Neuromuscular Facilitation Exercises in Temporomandibular Dysfunction
    on July 19, 2021 at 4:00 pm

    Conditions:   Temporomandibular Disorder;   Temporomandibular Joint Disorders;   PainIntervention:   Other: PNF exercisesSponsor:   Istanbul Medipol University HospitalRecruiting

  • Effect Of Sleep Apnea Treatment On Temporo-Mandibular Disorders
    on July 2, 2021 at 4:00 pm

    Conditions:   Sleep Apnea;   Sleep Apnea, Obstructive;   Sleep Apnea Syndromes;   Pain;   Pain, Face;   Temporomandibular DisorderInterventions:   Combination Product: osa treatment;   Other: no treatmentSponsor:   Anna Alessandri BonettiRecruiting

  • Myofascial Pain Syndrome and Dextrose Prolotherapy
    on June 28, 2021 at 4:00 pm

    Condition:   Efficacy of Dextrose Prolotherapy in Myofascial Pain SyndromeInterventions:   Drug: Injection of dextrose, local anesthetic and saline to the myofascial trigger point;   Drug: Local anesthetic and saline injection to the myofascial trigger pointSponsor:   Mustafa Kemal UniversityRecruiting

  • Effectiveness of Dry Needling in Fibromyalgia Patients
    on June 28, 2021 at 4:00 pm

    Conditions:   Fibromyalgia;   Chronic Pain;   Anxiety;   Depression;   Fatigue;   Sleep DisorderIntervention:   Other: Dry needlingSponsor:   CEU San Pablo UniversityRecruiting

  • China Headache Registry Study
    on June 25, 2021 at 4:00 pm

    Conditions:   Headache Disorders, Primary;   Headache Disorders, Secondary;   Migraine;   Tension-Type Headache;   Cluster Headache;   Vertigo, Constant;   Vestibular Migraine;   FibromyalgiaIntervention:   Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Zhejiang University;   First People's Hospital of Hangzhou;   Shaoxing People's Hospital;   Tiantai People's Hospital;   People's Hospital of Lin 'an City;   Deqing People's Hospital;   Jiaxing No.1 Hospital;   The First Affiliated Hospital of Zhejiang Chinese Medical University;   Huizhou Municipal Central Hospital;   The Affiliated Hospital of Hangzhou Normal University;   Quzhou City People's Hospital;   Xin Hua Hospital of Zhejiang Province;   Huzhou First People's Hospital;   Zhongshan Hospital Of Traditional Chinese Medicine;   Jiaxing Hospital of Traditional Chinese Medicine;   First Affiliated Hospital of Wenzhou Medical University;   Wenling First People's Hospital;   Hangzhou Hospital of Traditional Chinese MedicineRecruiting

  • Intra-articular Injection in Arthroscopic Management of Temporomandibular Diseases
    on June 23, 2021 at 4:00 pm

    Condition:   Temporomandibular Joint DisordersIntervention:   Procedure: Temporomandibular joint arthroscopy plus intra-articular injectionSponsor:   Sohag UniversityRecruiting

  • Integrative Therapy of Chronic Diseases
    on June 16, 2021 at 4:00 pm

    Condition:   Chronic DiseaseIntervention:   Sponsors:   Universität Duisburg-Essen;   Sozialstiftung BambergRecruiting

  • Remote Gamified Sensory Perceptual Training for Patients With Fibromyalgia: a Feasibility Trial
    on June 9, 2021 at 4:00 pm

    Condition:   FibromyalgiaIntervention:   Device: TrainPainSponsor:   Icahn School of Medicine at Mount SinaiRecruiting

  • The Effect of Group Exercise and Thetahealing on Pain and Quality of Life in Patients With Fibromyalgia
    on June 7, 2021 at 4:00 pm

    Condition:   FibromyalgiaInterventions:   Behavioral: exercises;   Behavioral: thetahealing and exercisesSponsor:   Inonu UniversityRecruiting

  • Montage of HTDCS in Psycho-cognitive Functions in FM
    on May 18, 2021 at 4:00 pm

    Condition:   FibromyalgiaIntervention:   Device: Transcranial Direct Current Stimulation (tDCS)Sponsor:   Hospital de Clinicas de Porto AlegreRecruiting

  • Resilience Factors and Selective Learning in Patients With Fibromyalgia
    on May 17, 2021 at 4:00 pm

    Condition:   FibromyalgiaInterventions:   Behavioral: Best Possible Self;   Behavioral: Typical DaySponsor:   Philipps University Marburg Medical CenterRecruiting


About ten million people in the U.S. have fibromyalgia – as does 6% of the world population. Yet, the origin of fibromyalgia remains mysterious. Proactive treatment for fibromyalgia relies on today’s fibromyalgia clinical studies and those who choose to participate. Patients of any age and background, including those with a family history of fibromyalgia, have important roles to play.

Match to Fibromyalgia Clinical Trials

  • Access to cutting-edge treatments
  • Latest clinical trials
  • Find trials in your area