Symptoms stay at the more severe level for days or even weeks. As acute exacerbation wears off, patients return to their usual level of symptoms.
What is Pulmonary Fibrosis?
ulmonary fibrosis is a disease in which lung tissue becomes scarred. Long-term damage to this tissue makes oxygen transfer in the body less efficient. Sufferers may find they are short of breath even when performing everyday activities.
Other symptoms include:
- A dry cough
- Muscle and joint aches
- Unexplained weight loss
- Fingers or toes that widen and become rounder at the tips
- Pulmonary fibrosis patients are at risk of acute exacerbation, a situation where symptoms get worse very quickly
What Causes Pulmonary Fibrosis?
Many cases of pulmonary fibrosis are idiopathic. This means there is no clear cause for the disorder. Idiopathic pulmonary fibrosis generally grows worse over time, but the exact prognosis varies from one person to another.
Pulmonary fibrosis symptoms may come on suddenly and worsen dramatically for one person while taking many years to progress for another. One of the key questions asked by pulmonary fibrosis research is what factors contribute to more rapid disease progression.
Not all cases of pulmonary fibrosis are idiopathic. Environmental factors can cause damage to the tissues between air sacs in the lungs, eventually leading to pulmonary fibrosis. The disease is more common in people in mining, farming, and construction.
Risk factors discovered to date include:
- Exposure to toxins including silica dust, coal dust, and asbestos fibers
- Certain forms of radiation therapy for treating lung or breast cancer
- Some chemotherapy drugs, heart medications, and antibiotic drugs
- Several other medical conditions affecting the lungs, like pneumonia
Pulmonary fibrosis clinical trials have grown in number in recent years. New clinical resources for pulmonary fibrosis are often offered to patients on a trial basis to determine their efficacy.
How is Pulmonary Fibrosis Diagnosed?
Pulmonary fibrosis evaluation begins with a standard exam. Here, a doctor will take a medical history and listen to the patient’s breathing using a stethoscope. Imaging tests including x-ray, CT scans, and echocardiogram can be used to look at the lungs and heart.
If imaging tests reveal concerns, lung function tests are performed.
One of the most common is pulmonary function testing. This may include spiormetry, which measures lung capacity when a patient exhales forcefully, or an exercise stress test measuring lung function while jogging on a treadmill.
How is Pulmonary Fibrosis Treated or Cured?
No medication can reverse the lung damage associated with pulmonary fibrosis. While future treatments may prove effective in stopping the course of the disease, none are available yet.
Pirfenidone and nintedanib are two recent medications being prescribed to slow the progress of idiopathic pulmonary fibrosis. Several other formulations are working through FDA approval.
Medication can ease symptoms of disorders that frequently appear alongside pulmonary fibrosis, such as GERD. Oxygen therapy and pulmonary rehabilitation are other options that strengthen and maintain lung capacity. In severe cases, lung transplantation is used.
Maintaining cardiovascular fitness through a personalized program of regular aerobic exercise is effective in helping many patients sustain healthier lungs.
Patients should be aware of how their body responds to exertion and avoid situations where they must stand or walk long periods of time without rest.
After a pulmonary fibrosis diagnosis, patients should cease smoking immediately. Also avoid situations where secondhand smoke or other airborne pollutants will be inhaled.
Pulmonary Fibrosis Clinical Trials
The following clinical trial are the most recent offered by Clinicaltrials.gov. If you would like us to feature any additional trials, please contact our team.
ClinicalTrials.gov: Recruiting Studies | Pulmonary Fibrosis | Last update posted in the last 300 days Studies found on ClinicalTrials.gov by a search of: Recruiting Studies | Pulmonary Fibrosis | Last update posted in the last 300 days
ANG-3070 in Healthy Adult Participants
on December 12, 2019 at 5:00 pm
Condition: Idiopathic Pulmonary FibrosisInterventions: Drug: ANG3070; Drug: Placebo oral capsuleSponsor: Angion Biomedica CorpRecruiting
Cardiovascular Fibrosis in Idiopathic Pulmonary Fibrosis
on November 26, 2019 at 5:00 pm
Conditions: Idiopathic Pulmonary Fibrosis; Cardiac Fibrosis; Arterial FibrosisIntervention: Sponsor: San Gerardo HospitalRecruiting
Comparison of Different Functional Capacity Tests in Cystic Fibrosis Patients With Acute Pulmonary Exacerbation
on November 22, 2019 at 5:00 pm
Conditions: Cystic Fibrosis in Children; Exercise CapacityIntervention: Diagnostic Test: 1-minute sit to stand testSponsor: Hacettepe UniversityRecruiting
Mucoid Staphylococcus Aureus in Cystic Fibrosis Airways
on November 21, 2019 at 5:00 pm
Conditions: Staphylococcus Aureus Pneumonia; Lung Diseases; Cystic Fibrosis; Lung Function DecreasedIntervention: Sponsor: University Hospital MuensterRecruiting
Korean Idiopathic Pulmonary Fibrosis Registry
on November 13, 2019 at 5:00 pm
Condition: Idiopathic Pulmonary FibrosisIntervention: Sponsor: Seoul National University HospitalRecruiting
Pulmonary Condensate: Non-invasive Evaluation of Pulmonary Involvement in Asthma and Cystic Fibrosis.
on November 8, 2019 at 5:00 pm
Conditions: Bronchial Asthma; Pulmonary Cystic FibrosisIntervention: Diagnostic Test: Collection of breath condensateSponsors: The Institute of Molecular and Translational Medicine, Czech Republic; University Hospital OlomoucRecruiting
Lung Elastrosonography in Diagnosis and Stratification of COPD and Fibrosis
on November 4, 2019 at 5:00 pm
Conditions: Chronic Obstructive Pulmonary Disease; Smoker LungIntervention: Diagnostic Test: Lung ElastosonographySponsor: Azienda Ospedaliero-Universitaria di ParmaRecruiting
Quality of Life in IPF - Patient and Physician Perceptions
on November 1, 2019 at 4:00 pm
Condition: Idiopathic Pulmonary FibrosisIntervention: Sponsors: University of Washington; Washington Research FoundationRecruiting
Integrated Radiographic and Metabolomics Risk Assessment in Patients With Interstitial Lung Diseases
on October 8, 2019 at 4:00 pm
Conditions: Lung Diseases, Interstitial; Pulmonary FibrosisInterventions: Device: CT-V; Other: MetabolitesSponsor: William Beaumont HospitalsRecruiting
Modeling of Chest Physiotherapy Using Impedance Measurements (PHYSIOMOD)
on September 19, 2019 at 4:00 pm
Condition: Cystic FibrosisIntervention: Other: chest physiotherapySponsor: Assistance Publique - Hôpitaux de ParisRecruiting
Phase 2a Evaluation of PLN-74809 on αvβ6 Receptor Occupancy Using PET Imaging in Participants With IPF/
on August 28, 2019 at 4:00 pm
Condition: Idiopathic Pulmonary FibrosisInterventions: Drug: PLN-74809; Drug: Placebo; Radiation: Knottin tracerSponsors: Pliant Therapeutics, Inc.; Stanford UniversityRecruiting
Clinical Utility of the 1-minute Sit to Stand Test as a Measure of Submaximal Exercise Tolerance in Patients With Cystic Fibrosis During Acute Pulmonary Exacerbation
on August 15, 2019 at 4:00 pm
Condition: Cystic FibrosisIntervention: Diagnostic Test: Sit to stand testSponsor: Boston Children’s HospitalRecruiting
Health and Quality of Life Assessment Project for Caregivers of Idiopathic Pulmonary Fibrosis Patients
on July 24, 2019 at 4:00 pm
Conditions: Idiopathic Pulmonary Fibrosis; Patient-caregiver DyadsInterventions: Other: Caregiver Quality of Life Questionnaires; Other: Patient Quality of Life QuestionnairesSponsor: Centre Hospitalier Universitaire DijonRecruiting
Impact of Early Lung Physiology, Viral Infections and the Microbiota on the Development and Progression of Lung Disease in Children With Cystic Fibrosis
on July 19, 2019 at 4:00 pm
Condition: Confirmed Diagnosis of Cystic FibrosisIntervention: Other: no interventionSponsors: University Hospital Inselspital, Berne; University Children's Hospital, Zurich; Centre Hospitalier Universitaire Vaudois; Kantonsspital Aarau; University Children's Hospital BaselRecruiting
Real-Life Use of Anti-fibrotic Drugs in Patients With Idiopathic Pulmonary Fibrosis in Sweden
on July 15, 2019 at 4:00 pm
Condition: Idiopathic Pulmonary FibrosisIntervention: Other: Anti-fibrostic drugsSponsor: Karolinska University HospitalRecruiting
Idiopathic Pulmonary Fibrosis and Serum Bank
on July 11, 2019 at 4:00 pm
Conditions: Idiopathic Pulmonary Fibrosis; Lung Diseases, InterstitialIntervention: Biological: Blood sample collectionSponsor: Rennes University HospitalRecruiting
Parameters to Assess Response to Intra-Venous Antibiotic Treatment for Pulmonary Exacerbations in Cystic Fibrosis
on July 11, 2019 at 4:00 pm
Condition: Cystic FibrosisIntervention: Sponsors: Belfast Health and Social Care Trust; Queen's University, BelfastRecruiting
Role of Body Fat Distribution in Metabolic and Pulmonary Decline in Cystic Fibrosis (ORBIT-CF)
on July 1, 2019 at 4:00 pm
Condition: Cystic FibrosisIntervention: Sponsors: Emory University; Cystic Fibrosis FoundationRecruiting
Early Detection of Acute Exacerbation in Patients With Idiopathic Lung Fibrosis - a Pilot Study
on June 7, 2019 at 4:00 pm
Conditions: Acute Exacerbation; Idiopathic Pulmonary Fibrosis; Home SpirometryIntervention: Other: Home spirometrySponsors: Heidelberg University; University of Giessen; Hannover Medical School; Ludwig-Maximilians - University of Munich; LungenClinic GrosshansdorfRecruiting
Yoga in Patients With Fibrosing Interstitial Lung Diseases
on June 7, 2019 at 4:00 pm
Conditions: Fibrosing Interstitial Lung Diseases; Idiopathic Pulmonary FibrosisIntervention: Other: 12 week yoga classSponsors: Heidelberg University; Lungenfibrose e.V.Recruiting