Why is Weight Loss Important?


ecent research indicates about 70 million U.S. adults are obese and 99 million are overweight. In 2017, 42% of Americans were obese, a rise of around 12% compared to 1999.

All in all, experts agree obesity is a widespread problem in the United States. The average person seems to concur: About 45 million Americans go on a diet each year.

Unfortunately, standard diet and exercise regimes produce limited results for many people. In recent years, the emergence of serious health complications related to weight has led to more people seeking medical supervision for their weight loss efforts.

On the whole, people who maintain a healthy weight, exercise regularly, and eat a balanced diet have a higher life expectancy than those who are classified as overweight or obese.

What Conditions Are Associated With Weight Loss?

As weight increases, so too does the risk of many different health conditions. High blood pressure is a common complication of being overweight that can also raise one’s risk of heart attack and stroke. Overweight people are also less likely to survive these events.

Unhealthy weight raises the risk of many other conditions, including heart disease, diabetes, high cholesterol, arthritis, and several others. Many of these are common. Overweight people who already have a genetic disposition to any of these conditions are at very high risk.

Sustained weight loss and management can curb many of these risks. If weight loss is achieved before health problems begin, the patient becomes less likely to develop those complications, even with advancing age. Health benefits are brought about by increased heart efficiency, improved muscle mass, better blood circulation, and many other factors.

Weight Loss Methods and Lifestyle Changes

Weight loss methods range from self-directed diet and exercise to medically supervised weight loss regimes to surgical intervention. Many patients benefit from combining several methods.

Weight loss surgery, such as lap band surgery, is generally only practiced on those who are severely obese whose condition has not responded to a medically supervised weight loss plan.

Lifestyle changes focus on reducing portions, changing meal times, improving nutrition, and raising the amount of physical exercise a person engages in. Once weight loss is achieved, these lifestyle changes must remain in place to avoid regaining lost weight in the future.

Recent Weight Loss Medical Research

Weight loss is one of human biology’s most complex topics. Weight loss medical research can focus on many aspects of this challenging process.

Some researchers are interested in the way the body signals appetite and stores fat and how these functions can be adjusted in healthy ways. Others focus on the neurology of behaviors that can lead to obesity or the role of hormones in the body’s weight regulation.

Why Are Further Weight Loss Clinical Trials Necessary?

Over the last several years, a great deal of weight loss medical research has focused on metabolic syndrome, a cluster of conditions associated with weight gain. Weight loss clinical trials are essential to understanding how this syndrome impedes weight loss for teens, adolescents, and adults, and the role played by co-occuring conditions.

Current Weight Loss Clinical Trials

This directory of weight loss clinical trials includes all weight loss clinical studies in the ClinicalTrials.gov database. To add a study to our list, contact us.


Virtually all Americans are affected by the health issues caused by weight or know someone who is. However, sustained weight loss is not simply a matter of “willpower.” More weight loss clinical trials are needed to uncover the complex biological processes that can make weight loss difficult.