A Guide To Urticaria

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What is Urticaria?

Urticaria is a common skin disorder also known as hives.

It can present in two main forms: Chronic Spontaneous Urticaria (CSU) describes a condition where hives are present for most days of the week for at least six weeks. Acute Urticaria is a similar condition, but it presents for fewer than six weeks.

Physical urticaria happens only when an irritating stimulus is applied to the skin; the hives fade when the stimulus is withdrawn. It is understood as an allergic reaction.

CSU and acute urticaria are known collectively as spontaneous urticaria and may require medical care.

What Conditions Are Associated With Urticaria?

Both CSU and acute urticaria can be debilitating due to the itching and pain the hives cause. The disorder is considered uncommonly difficult to treat among dermatological conditions. It is also a more emotionally demanding condition, which can cause great mental distress.

Flare-ups of urticaria are sudden and occur without warning. Itchy, burning, rash-like lesions can appear virtually anywhere on the skin. Individual lesions are called wheals. One characteristic of urticaria is the very short duration of the wheals, each fading within 24 hours.

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Urticaria Recovery and Lifestyle Changes

The various forms of urticaria can be difficult to diagnose. This is because there can be several causes for any patient to develop wheals similar to urticaria. A complete diagnosis requires identifying any environmental factors that might contribute to the symptoms.

Some very effective treatments are available, but must be prescribed and used correctly. Most treatments center around non-sedating antihistamines. Antihistamines interfere with some of the body’s inflammatory responses and are also used to treat certain allergies.

Although the exact source of urticaria is not yet understood, doctors do know certain physical stimuli can lead to flare-ups. These include things like alcoholic drinks, over-the-counter NSAID medications like aspirin and ibuprofen, exercise, and extreme temperatures (both hot and cold.)

Patients can improve their symptom management by noticing which stimuli most often lead to their own flare-ups. By reducing or avoiding contact with these factors, many can substantially reduce the number of flare-ups they experience.

Recent Urticaria Medical Research

Nearly half of all cases of urticaria are associated with autoimmune dysfunction. The immune system can become too responsive to benign stimuli, leading to inflammation with no protective purpose. The course of treatment varies based on whether immune function is involved.

With that in mind, most medical research on urticaria is focused on finding targeted ways to counteract overactive immune function. Urticaria clinical studies also strive to uncover the other factors that might be involved in spontaneous urticaria, such as genetic factors.

Why Are Further Urticaria Clinical Studies Necessary?

Urticaria is unusual among dermatological conditions and has received plenty of attention. While urticaria clinical research has been successful so far, physicians have not been able to answer why some people get urticaria or isolate the risk factors involved.

Both acute and chronic spontaneous urticaria clinical trials are necessary if doctors are to fully understand these diseases and develop better treatments. Recent urticaria medical research led to promising findings, with several novel medications under development.

Current Urticaria Clinical Studies

The following list includes all urticaria clinical studies registered with ClinicalStudies.gov. To submit urticaria clinical studies to our list, please contact our team.


Although there are several treatments for spontaneous urticaria, many patients receive few benefits or have adverse reactions. Likewise, some specific forms of the disorder have few effective treatment options. Urticaria clinical studies are an essential piece in broadening the horizons of urticaria medical research and improving patients’ quality of life.

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