What is Coronavirus?

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ovel Wuhan Coronavirus 2019, more often called coronavirus or COVID-19, is a new strain of virus similar in structure to SARS. It produces respiratory symptoms after an incubation period ranging 1-14 days.

Coronavirus is principally spread by contact with respiratory droplets from an infected person. A healthy person may inhale these in close proximity with a sufferer. They may also touch a surface with the droplets, then transfer the virus by touching the face, eyes, nose, or mouth.

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What Conditions is Coronavirus Associated With?

Coronavirus disease, more commonly called COVID-19, is an infectious respiratory illness. It causes flu-like symptoms that typically include dry cough, body aches, and fever. Some patients have no symptoms. In more severe cases, difficulty breathing develops.

Difficulty breathing arises from two factors: The initial attack on the lungs and the body’s inflammatory response. Inflammation is a result of immune system activity and serves to limit the virus from progressing through the lungs.

Initial research indicated people over age 60 were at greatest risk of coronavirus hospitalization. Young children may have limited protection from the disease. However, significant coronavirus symptoms have been observed in all age groups.

Coronavirus Recovery and Lifestyle Changes

Around 50% of people in the United States live in an area where social distancing has been ordered by state or local governments.

Social distancing is a means of reducing coronavirus spread by remaining at least six feet apart at all times, staying isolated as much as possible from others you do not live with, and washing your hands regularly. Many people have been ordered not to report to work.

Approximately 80% of coronavirus cases do not result in hospitalization. An unknown number of cases do not result in any symptoms. However, even people with no symptoms may “shed” the virus, enabling it to be passed on.

Most patients recover within about 10-14 days of experiencing symptoms. Of those, mild or moderate cases do not lead to permanent loss of lung capacity. However, even patients who no longer experience symptoms are infectious for up to two weeks.

The most intensive cases can lead to viral pneumonia and permanently impair lung function.

What Research Currently Exists Around Coronavirus?

Coronavirus research is proceeding at a fast pace. Researchers around the world are hard at work on potential treatments. At least three promising vaccines are in development in the U.S., Europe, and China.

There is no cure or vaccine for coronavirus. Treatment is limited to what can be done to reduce symptoms during recovery. Still, the slow rate of mutation exhibited by the coronavirus suggests a vaccine could offer lasting protection.

Why Are Further Coronavirus Clinical Trials Important?

Coronavirus fatality rates have been estimated anywhere from 1%-4%. Coronavirus clinical trials have the potential to save millions of lives that would otherwise be lost over the next several years. With global interest in coronavirus vaccine, coronavirus clinical trials benefit from former coronavirus patients as well as those who have never been exposed to the disease.

Current Coronavirus Clinical Trials

This is the current list of active coronavirus clinical trials registered with ClinicalTrials.gov.

New clinical resources for coronavirus are being developed rapidly. Patients and their families should watch this space for announcements about coronavirus clinical studies.

  • Host Response Mediators in Coronavirus (COVID-19) Infection
    on August 12, 2020 at 4:00 pm

    Conditions:   COVID-19;   SARS-CoV2Interventions:   Other: ARBs and/or ACE inhibitors;   Other: Usual CareSponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR);   British Columbia Centre for Disease Control;   McGill University Health Centre/Research Institute of the McGill University Health Centre;   University of Toronto;   University of Ottawa;   University of Calgary;   University of Alberta;   University of Victoria;   Wuhan University;   Peking Union Medical College;   University of PennsylvaniaRecruiting

  • Characterizing the Immune Response and Neuronal Damage in COVID-19
    on August 12, 2020 at 4:00 pm

    Conditions:   SARS-CoV Infection;   Covid-19Intervention:   Other: Analysis of cytokine response, innate and adaptive immune response, complement activation, and serum neurofilaments as a marker of neurological damage.Sponsors:   University Hospital Inselspital, Berne;   University of BernRecruiting

  • Capturing MultiORgan Effects of COVID-19
    on August 12, 2020 at 4:00 pm

    Conditions:   Coronavirus Infection;   Multi-Organ DisorderIntervention:   Diagnostic Test: Magnetic Resonance ImagingSponsor:   University of OxfordRecruiting

  • Artificial Intelligence-assisted Diagnosis and Prognostication in COVID-19 Using Electrocardiograms
    on August 12, 2020 at 4:00 pm

    Condition:   CoronavirusIntervention:   Other: Nil interventionSponsors:   Imperial College London;   Imperial College Healthcare NHS Trust;   Chelsea and Westminster Hospital NHS Foundation Trust;   LONDON NORTH WEST UNIVERSITY HEALTHCARE NHS TRUSTRecruiting

  • The McMaster Multi-Regional COVID-19 Hospital Case Registry
    on August 11, 2020 at 4:00 pm

    Conditions:   Coronavirus Infection;   Coronavirus;   SARS-CoV-2 Infection;   Covid19Intervention:   Sponsors:   McMaster University;   Canadian Institutes of Health Research (CIHR);   Hamilton Academic Health Sciences Organization;   Grand River Hospital;   Niagara Health System;   St. Mary's General Hospital;   Hamilton Health Sciences Corporation;   St. Joseph's Healthcare HamiltonRecruiting

  • Burden for STaff Working in the NHS
    on August 10, 2020 at 4:00 pm

    Conditions:   COVID-19;   Mental Health BurdenIntervention:   Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   University of SheffieldRecruiting

  • A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults in the Era of Coronavirus Disease 2019
    on August 10, 2020 at 4:00 pm

    Conditions:   Covid19;   Atherosclerosis;   Cardiovascular Diseases;   Upper Respiratory Tract InfectionsIntervention:   Drug: Icosapent ethylSponsors:   Kaiser Permanente;   Amarin CorporationRecruiting

  • COVID-19 Seroprevalence Study in ITM Staff
    on August 7, 2020 at 4:00 pm

    Condition:   Covid19Intervention:   Sponsor:   Institute of Tropical Medicine, BelgiumRecruiting

  • Behavior During and After COVID-19 Crisis
    on August 6, 2020 at 4:00 pm

    Conditions:   Exercise;   Nutritional Status;   SleepIntervention:   Behavioral: Covid19Sponsor:   Slavko RoganRecruiting

  • Therapeutics for Inpatients With COVID-19
    on August 6, 2020 at 4:00 pm

    Condition:   Covid19Interventions:   Drug: LY3819253;   Drug: Placebo;   Drug: RemdesivirSponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   International Network for Strategic Initiatives in Global HIV Trials (INSIGHT);   University of Copenhagen;   Medical Research Council;   Kirby Institute;   Washington D.C. Veterans Affairs Medical Center;   AIDS Clinical Trials Group;   National Heart, Lung, and Blood Institute (NHLBI);   US Department of Veterans Affairs;   Prevention and Early Treatment of Acute Lung Injury (PETAL);   Cardiothoracic Surgical Trials Network (CTSN)Recruiting

  • Open-label Treatment of Severe Coronavirus Disease 2019 (COVID-19) With Convalescent Plasma
    on August 6, 2020 at 4:00 pm

    Condition:   Covid-19Intervention:   Biological: Convalescent plasma transfusionSponsor:   Inova Health Care ServicesRecruiting

  • Cardiac Rehabilitation and Ongoing Physical Activity During COVID-19
    on August 6, 2020 at 4:00 pm

    Condition:   Cardiac RehabilitationIntervention:   Other: No interventionSponsors:   Ludwig Boltzmann Institute for Digital Health and Prevention;   Institute of Sports Medicine, Prevention and Rehabilitation, Salzburg, AustriaRecruiting

Conclusion

The coronavirus pandemic is like no other public health challenge in living memory. People around the world are banding together to slow the spread and find treatments. Coronavirus clinical resources depend on those who follow all social distancing guidelines, support their community’s medical professionals, and participate in coronavirus clinical trials if possible.

Match to Coronavirus Clinical Trials

  • Access to cutting-edge treatments
  • Latest clinical trials
  • Find trials in your area