What is Epilepsy?

E

pilepsy is the fourth most common neurological condition in the United States. Suffers experience chronic, unprovoked seizures caused by abnormal signaling activity in the brain.

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  • Latest clinical trials
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What Conditions Are Associated With Epilepsy?

Children and the elderly are at greatest risk of epilepsy. Some childhood forms of the disorder can fade away completely over time. Conversely, older adults may develop epilepsy suddenly.

There are different types of seizures, and a patient with epilepsy may experience several kinds. When a variety of features all occur together, they can be categorized as an epilepsy disorder.

Epilepsy can be categorized based on these and other factors:

  • The types of seizures the sufferer has.
  • The age when the seizures first began.
  • Genetic contributions to the condition.

Researchers recognize about two dozen distinct epilepsy syndromes.

The most common epilepsy syndromes include:

Benign Rolandic Epilepsy (BRE)

The most common epilepsy in children, it’s called “benign” because most patients will outgrow it by puberty. Seizures typically occur between 3-12 years old and happen at night. Headaches and migraines can also occur. There is a strong genetic component.

Remote Symptomatic Epilepsy

Remote symptomatic epilepsy is the most common form of epilepsy in older people. It simply refers to epilepsy that was brought on by physical trauma elsewhere in the body. It is most often associated with stroke. Alzheimer’s disease also increases the risk of epilepsy

The type of seizure known as the grand mal seizure or generalized convulsion has appeared in popular media many times. During a seizure like this, the patient loses motor control and often falls unconscious. However, this is only one of many types of seizures, some less intense.

Epilepsy Recovery and Lifestyle Changes

There is no cure for epilepsy. After its onset, most patients experience symptoms for life. These symptoms can be intermittent and may not present for weeks or months at a time. However, patients must be alert to potential safety risks at all times. Drugs can control seizures for about 70% of patients. Patients should remain under a doctor’s care and use medication as directed.

One of the most important aspects of long-term symptom management is determining whether any environmental stimuli can provoke a seizure in a particular patient. When stimuli can cause seizures, it is called reflex epilepsy. Bright or flashing lights are among the most common seizure triggers. Sounds and certain activities may provoke seizures, too, and should be avoided.

Recent Epilepsy Medical Research

For more than 40 years, medical research has benefited from frequent epilepsy clinical trials. New epilepsy medications are always under investigation. One of the biggest discoveries from epilepsy clinical trials is the effectiveness of certain medical cannabis treatments for seizure management, especially for pediatric patients with treatment-resistant symptoms. It was this discovery that helped propel public interest in medical cannabis for other purposes.

Why Are Further Epilepsy Clinical Trials Necessary?

With two dozen distinct manifestations of epilepsy to research, progress against the disorder can be slow. Further epilepsy clinical trials can help at-risk populations, including youths and elders. A great deal of information remains to be uncovered about epilepsy, such as the precise genetic factors that can contribute to it and whether or how it can be prevented.

Current Epilepsy Clinical Trials

The following list includes all epilepsy clinical trials verified by ClinicalTrials.gov. To add an epilepsy clinical trial to our list, just contact our team.

  • Brain-Shift Monitoring Using 3D Scanning
    on August 24, 2021 at 4:00 pm

    Condition:   Craniotomy for Epilepsy and Malignant Tumor RemovalIntervention:   Device: Brain shift monitoringSponsor:   Advanced Scanners Inc.Recruiting

  • Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
    on August 24, 2021 at 4:00 pm

    Conditions:   Temporal Lobe Epilepsy;   Open Surgery;   Minimally Invasive SurgeryInterventions:   Procedure: Functional temporal lobectomy (FTL);   Procedure: Anterior temporal lobectomy (ATL)Sponsor:   Zhang HuaRecruiting

  • The Neural Coding of Speech Across Human Languages
    on August 20, 2021 at 4:00 pm

    Conditions:   Epilepsy;   Brain Tumor;   Speech;   BilingualismIntervention:   Behavioral: Speech TasksSponsors:   University of California, San Francisco;   University of California, Berkeley;   Lawrence Livermore National Laboratory;   The University of Hong Kong;   National Institute of Neurological Disorders and Stroke (NINDS)Recruiting

  • Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic Epilepsies
    on August 20, 2021 at 4:00 pm

    Conditions:   Epilepsies, Partial;   Epilepsy IntractableInterventions:   Diagnostic Test: Standard of care;   Diagnostic Test: Functional magnetic resonance imaging-Electroencephalogram combined analysis;   Diagnostic Test: High density- electroencephalogram or 7 Tesla magnetic resonance imagingSponsor:   IRCCS Eugenio MedeaRecruiting

  • Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam
    on August 17, 2021 at 4:00 pm

    Conditions:   Epilepsy;   Pyridoxine;   Behavior ProblemInterventions:   Drug: Pyridoxine;   Drug: PlaceboSponsors:   Nasim Tabrizi;   Mazandaran University of Medical SciencesRecruiting

  • Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery
    on August 3, 2021 at 4:00 pm

    Condition:   Focal EpilepsyInterventions:   Diagnostic Test: Brain magnetic resonance imaging;   Behavioral: Neuro-psychology testingSponsors:   Wayne State University;   National Institutes of Health (NIH)Recruiting

  • Efficacy and Safety of Rapamycin Versus Vigabatrin in the Prevention of Tuberous Sclerosis Complex Symptoms in Infants
    on August 3, 2021 at 4:00 pm

    Condition:   Tuberous Sclerosis ComplexInterventions:   Drug: Vigabatrin;   Drug: Rapamycin;   Drug: PlaceboSponsor:   Katarzyna KotulskaRecruiting

  • Exercise for Memory Rehabilitation in Epilepsy
    on July 12, 2021 at 4:00 pm

    Conditions:   Epilepsy, Generalized;   Memory ImpairmentInterventions:   Behavioral: Supervised combined endurance and resistance training (CERT);   Behavioral: Delayed supervised combined endurance and resistance training (CERT)Sponsor:   University of Alabama at BirminghamRecruiting

  • EASINESS-TRIAL - Enhancing Safety in Epilepsy Surgery
    on July 7, 2021 at 4:00 pm

    Conditions:   Epilepsy, Temporal Lobe;   Amygdalo-Hippocampal EpilepsyIntervention:   Procedure: Mesial temporal lobe epilepsy surgerySponsors:   Universitätsklinikum Hamburg-Eppendorf;   Charite University, Berlin, Germany;   University of Erlangen-Nürnberg;   University Clinic Frankfurt;   Vienna General HospitalRecruiting

  • Epilepsy Prevalence and Intervention Study in Zhejiang Province, China
    on June 29, 2021 at 4:00 pm

    Condition:   EpilepsyInterventions:   Behavioral: education on epilepsy;   Drug: routine and proper antiepileptic drugsSponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Hangzhou Center of Disease Control and Prevention;   The Central Hospital of Lishui City;   the second hospital of Jiaxing city;   Shengzhou People's Hospital;   Children's Hospital Affiliated to Zhejiang University School of MedicineRecruiting

  • Phenylbutyrate for STXBP1 Encephalopathy and SLC6A1 Neurodevelopmental Disorder
    on June 23, 2021 at 4:00 pm

    Condition:   STXBP1 Encephalopathy With Epilepsy, SLC6A1 Neurodevelopmental DisorderIntervention:   Drug: Glycerol Phenylbutyrate 1100 MG/ML [Ravicti]Sponsor:   Weill Medical College of Cornell UniversityRecruiting

  • The Research of Human Cortex Cell Atlas
    on June 15, 2021 at 4:00 pm

    Conditions:   Aging;   Epilepsy;   Trauma, BrainIntervention:   Other: brain tissue single-cell sequencingSponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang UniversityRecruiting

Conclusion

About 50 million people worldwide have epilepsy. With further epilepsy clinical trials, it will be possible to strive toward better epilepsy medication and, eventually, a true cure for epilepsy.

Match to Epilepsy Clinical Trials

  • Access to cutting-edge treatments
  • Latest clinical trials
  • Find trials in your area