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Learn More About Currently Running Clinical Trials for Parkinson's Disease

What is Parkinson’s Disease?

P

arkinson’s disease is a progressive neurodegenerative disorder that impacts dopamine-producing neurons in the substantia nigra, part of the midbrain. Symptoms often develop very slowly over a period of years or decades and are not always noticeable at first.

As the disease progresses, patients experience problems with movement. Though tremors are the characteristic symptom of Parkinson’s, it can cause stiffness or slowed movement. These symptoms may be more noticeable on one side of the body than the other.

Over time, damage to the midbrain continues and symptoms tend to get worse. People with advanced Parkinson’s disease may suffer changes in their gait and have difficulty walking.

What Causes Parkinson’s Disease?

The precise cause of Parkinson’s disease is not yet known. Much research is being completed to try an uncover this, as it will aid in prevention and treatment. Although it is not fatal by itself, the symptoms can seriously impact quality of life. Likewise, some complications leave a patient at greater risk of injury or other health issues.

In addition to dopamine-producing nerve cells, people with Parkinson’s lose nerve endings responsible for producing norepinephrine, which regulates the autonomic nervous system. This leads to disruption in automatic functions like heart rate and blood pressure.

Current Parkinson’s research focuses on the presence of Lewy bodies in patients’ brain cells. These unusual clumps of protein may be related to certain genetic mutations.

Parkinson’s clinical trials attract more participants than many other chronic diseases. The Michael J. Fox foundation is a leading organization dedicated to finding more advanced treatments and a cure for Parkinson’s disease. Millions of dollars from other outside resources have also been donated to study it. A variety of new clinical resources for Parkinson’s are in advanced stages of development.

Interested in Participating?

Learn More About Currently Running Clinical Trials for Parkinson's Disease

How is Parkinson’s Disease Diagnosed?

Unfortunately, at this point no one test can diagnose Parkinson’s disease. It’s essential to see a neurologist who can conduct a variety of tests evaluating the health of the whole nervous system.

When it is unclear whether symptoms support a Parkinson’s diagnosis, a specialized single-photon emission computerized tomography (SPECT) scan is used. Blood tests are also used to rule out other potential explanations for symptoms. Diagnosis may take several months.

In many cases, doctors will prescribe a short-term course of treatment with Parkinson’s disease medication. Patients who experience symptom relief after treatment can confirm their diagnosis.

How is Parkinson’s Disease Treated or Cured?

Although no treatment restores damaged neurons, medications can moderate the symptoms of Parkinson’s disease. The most common, a combination medication called carbidopa-levodopa in its generic form, works directly on the dopamine supply in the brain.

While the levodopa converts into dopamine in the brain, the carbidopa prevents it from breaking down and allows more of it to be converted. This supports the brain’s natural absorption and use of dopamine, which improves voluntary control of body movement.

Several other medications may be used, either long-term or in the disease’s later stages.

A surgical procedure called deep brain stimulation helps some patients as Parkinson’s gets more severe. In this procedure, electrodes are implanted into the brain. A doctor can fine-tune the electrical signals sent by these devices to reduce day to day symptoms.

Parkinson’s Disease Lifestyle Changes

Some lifestyle changes can help patients maintain quality of life and manage symptoms. Many doctors recommend Parkinson’s patients undertake ongoing aerobic exercise.

Stretching can improve balance and coordination, making falls less likely. For those who experience speech issues, therapy with a speech language pathologist can maintain abilities.

Patients should become familiar with common mobility aids and consider changes to make the home environment safer, such as grab bars in the tub to reduce the risk of falling.

Parkinson’s Disease Clinical Trials

The following clinical trial are the recent offered by Clinicaltrials.gov. If you would like us to showcase any further trials, please contact our team.

ClinicalTrials.gov: Recruiting Studies | Parkinson Disease | Last update posted in the last 300 days Studies found on ClinicalTrials.gov by a search of: Recruiting Studies | Parkinson Disease | Last update posted in the last 300 days

  • Taxonomy of Neurorehabilitation Treatments and Outcome Measures: a Multicentre Italian Study
    on May 13, 2020 at 4:00 pm

    Conditions:   Multiple Sclerosis;   Stroke;   Parkinson DiseaseIntervention:   Sponsors:   Fondazione Don Carlo Gnocchi Onlus;   IRCCS San Camillo, Venezia, Italy;   Universita degli Studi di Genova;   AIAS di Milano Onlus;   Ospedale San Carlo Borromeo;   Università degli studi di Trieste;   Ospedale San Giovanni Battista ACISMOM;   Presidio Ospedaliero San Camillo di Torino;   Istituto di Riabilitazione Santo Stefano, Macerata, Italy;   Ospedali Riuniti Ancona;   Foligno HospitalRecruiting

  • Study Assessing Efficacy and Safety of AKST4290 in Subjects With Parkinson's Disease on Stable Dopaminergic Treatment
    on April 30, 2020 at 4:00 pm

    Condition:   Parkinson DiseaseInterventions:   Drug: AKST4290;   Drug: PlaceboSponsor:   Alkahest, Inc.Recruiting

  • Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity
    on April 24, 2020 at 4:00 pm

    Conditions:   DBS;   Parkinson Disease;   Essential TremorIntervention:   Other: EMG, EEG, MEG, MRISponsors:   The Cleveland Clinic;   Farmer FoundationRecruiting

  • Cryotherapy Versus Radiofrequency Ablation for Treatment of Para-hisian Accessory Pathways
    on April 24, 2020 at 4:00 pm

    Conditions:   Cardiac Arrhythmias;   Accessory Pathway;   Wolf Parkinson White SyndromeInterventions:   Device: Radiofrequency (RF);   Device: Cryotherapy (CRYO)Sponsors:   University of Sao Paulo General Hospital;   InCor Heart Institute;   MedtronicRecruiting

  • UPDRS-III Comparisons of DBS for PD Between Patients Receiving MAC and AAA Anesthesia
    on April 24, 2020 at 4:00 pm

    Conditions:   Parkinson Disease;   AnesthesiaInterventions:   Procedure: MAC anesthesia;   Procedure: AAA anesthesiaSponsor:   Shenzhen Second People's HospitalRecruiting

  • Induction and Recognition of Emotions
    on April 21, 2020 at 4:00 pm

    Conditions:   Healthy Older Adults;   Alzheimer's Disease;   Parkinson's DiseaseInterventions:   Diagnostic Test: Mini Cognitive Examination (MCE);   Diagnostic Test: Beck Depression Inventory-II (BDI-II);   Diagnostic Test: Global Deterioration Scale (GDS);   Diagnostic Test: Memory alteration test ([email protected]);   Diagnostic Test: Spanish-Complutense Verbal Learning Test (TAVEC);   Diagnostic Test: Barcelona test (BT);   Diagnostic Test: Rey-Osterrieth Complex Figure Test (ROCFT);   Diagnostic Test: Frontal assessment battery (FAB);   Diagnostic Test: Positive and Negative Affect Scale (PANAS);   Diagnostic Test: Auto-Assessment Manikins (SAM)Sponsors:   University of Valencia;   Asociación Parkinson ValenciaRecruiting

  • LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers
    on April 16, 2020 at 4:00 pm

    Condition:   Parkinson DiseaseIntervention:   Sponsors:   Xuanwu Hospital, Beijing;   Michael J. Fox Foundation for Parkinson's ResearchRecruiting

  • A Through QT/QTc Study of KW-6356
    on April 13, 2020 at 4:00 pm

    Condition:   Parkinson's DiseaseInterventions:   Drug: KW-6356;   Drug: Placebo;   Drug: MoxifloxacinSponsor:   Kyowa Kirin Co., Ltd.Recruiting

  • Longitudinal Analysis of Gait Variability to Predict Falls in Parkinson's Disease
    on April 9, 2020 at 4:00 pm

    Conditions:   Parkinson Disease;   Healthy AgingIntervention:   Other: Cognitive dual-task walkingSponsors:   University of Nebraska;   National Institute of General Medical Sciences (NIGMS)Recruiting

  • ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
    on April 7, 2020 at 4:00 pm

    Conditions:   Obstructive Sleep Apnea;   Alzheimer Disease;   Vascular Dementia;   Mild Cognitive Impairment;   Parkinsons Disease With Dementia;   Dementia With Lewy Bodies;   Mixed DementiaInterventions:   Device: In-laboratory polysomnography;   Device: Home Sleep Apnea TestSponsors:   Sunnybrook Health Sciences Centre;   St. Michael's Hospital, TorontoRecruiting

  • Brain Stimulation for Patients With Parkinson Disease
    on April 3, 2020 at 4:00 pm

    Condition:   Parkinson DiseaseInterventions:   Device: TPS (NEUROLITH);   Device: Sham-TPS (NEUROLITH)Sponsor:   Storz Medical AGRecruiting

  • Study Investigating Effects of Foliglurax in Patients With Parkinson's Disease (PD) and Healthy Subjects
    on March 26, 2020 at 4:00 pm

    Conditions:   Parkinson Disease;   HealthyInterventions:   Drug: Foliglurax 10 mg (treatment A);   Drug: Foliglurax 30 mg (treatment B);   Drug: Placebo (treatment C)Sponsor:   H. Lundbeck A/SRecruiting