California is currently home to 5966 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Recruiting
This phase II Lung-MAP treatment trial studies the effect of AMG 510 in treating non-squamous non-small cell lung cancer that is stage IV or has come back (recurrent) and has a specific mutation in the KRAS gene, known as KRAS G12C. Mutations in this gene may cause the cancer to grow. AMG 510, a targeted treatment against the KRAS G12C mutation, may help stop the growth of tumor cells.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/09/2022
Locations: Kaiser Permanente-Anaheim, Anaheim, California
Conditions: Lung Adenocarcinoma, Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Squamous Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial
Recruiting
Cooled radiofrequency ablation (cRFA) of the knee geniculate nerves is a promising treatment option for knee osteoarthritis, but has variable efficacy. Fluoroscopy is the typical guidance of choice, but uses bony landmarks to target these nerves which have variable positions around the knee. Alternatively, ultrasound allows for targeting based on visualization of bony landmarks, the nerves, and their accompanying vascular structures, and thus may offer greater accuracy. However, there are few st... Read More
Gender:
All
Ages:
Between 35 years and 99 years
Trial Updated:
11/09/2022
Locations: UC Davis Health, Sacramento, California
Conditions: Knee Osteoarthritis
Boost Intentions and Facilitate Action to Promote COVID-19 Booster Take-up
Recruiting
This is a prospective randomized clinical trial evaluating how behaviorally-informed outreach text messages affect the take-up of bivalent COVID-19 booster. The investigators will test the impact of sending text reminders as well as the importance of elevating vaccination intentions, facilitating action, and their combination.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: UCLA Health Department of Medicine, Quality Office, Los Angeles, California
Conditions: COVID-19, Vaccines
Information Provision and Consistency Framing to Increase COVID-19 Booster Uptake
Recruiting
This study investigates different ways to elevate intentions to get the COVID-19 booster via text-based reminders, including providing information about the booster and leveraging the consistency principle. The proposed randomized controlled trial will examine the impact of these reminders on booster uptake.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: UCLA Health Department of Medicine, Quality Office, Los Angeles, California
Conditions: COVID-19, Vaccines
Dose-escalation Study of Safety of PBCAR19B in Participants With CD19-expressing Malignancies
Recruiting
This is a Phase 1, nonrandomized, open-label, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR19B in adult study participants with CD-19 expressing malignancies.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: City of Hope, Duarte, California
Conditions: CD19 Expressing Malignancies, Hematologic Malignancy
StimRouter Registry Clinical Protocol
Recruiting
This Registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes, health-related quality of life, concomitant medical use, and subject's impression of improvement.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/07/2022
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Pain, Peripheral Neuropathy, Nervous System Diseases, Peripheral Nervous System Diseases, Peripheral Nervous System Problem, Peripheral Nerve Injuries, Peripheral Nervous
MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: UCSF Orthopedic Institute, San Francisco, California
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
Effects of Prompt to Bundle COVID-19 Booster and Flu Shot
Recruiting
This randomized controlled trial investigates whether text-based reminders can increase the bivalent COVID-19 booster uptake and whether text-based reminders that mention the opportunity to bundle the COVID-19 booster with the flu shot within the same appointment can increase take-up of both the COVID-19 booster and the flu vaccine.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/04/2022
Locations: UCLA Health Department of Medicine, Quality Office, Los Angeles, California
Conditions: COVID-19, Vaccines
Evaluation of the Building Healthy Life Skills Program
Recruiting
The goal of this intervention trial is to learn test whether participation in the Building Health Life Skills Program leads to improvements in psychological well-being and stress management skills for people who are experiencing homelessness and housing insecurity. The main questions it aims to answer are: Will participation in the Building Healthy Life Skills Program lead to better skills in managing negative emotions? Will participation in the Building Healthy Life Skills Program lead to impr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: University of California Merced, Merced, California
Conditions: Adverse Childhood Experiences, Housing Problems, Emotion Regulation
A Latino MSM Focused Pre-Exposure Prophylaxis Uptake Intervention
Recruiting
The clinical study will evaluate the feasibility and acceptability of a culturally tailored behavioral intervention to improve uptake of pre-exposure prophylaxis for HIV prevention among at-risk Latino men who have sex with men.
Gender:
Male
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: Bienestar Human Services, Los Angeles, California
Conditions: HIV
A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy
Recruiting
To evaluate the durability of efficacy and long-term safety of intramuscular (IM) administration of Engensis or Placebo that was administered in the double-blind, randomized, VMDN-003-2 Placebo-controlled Phase 3 Study.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: California Medical Clinic for Headache, Los Angeles, California
Conditions: Diabetic Peripheral Neuropathy
TRUEBEAM Stereotactic Body Radiotherapy for Localized Prostate Cancer
Recruiting
The purpose of this study is to determine the effects of TrueBeam stereotactic body radiosurgery in patients with prostate cancer. The device is designed to concentrate large doses of radiation onto the tumor so that injury from radiation to the nearby normal tissue will be minimal. The purpose of this evaluation is to see if this treatment will help patients with your condition and to evaluate the effect of this treatment on your quality of life over time. Radiosurgery is a non-invasive treatme... Read More
Gender:
Male
Ages:
All
Trial Updated:
11/03/2022
Locations: MemorialCare Saddleback Medical Center, Laguna Hills, California
Conditions: Prostate Cancer