California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Blood Flow Monitoring to Prevent Post-Polypectomy Induced Ulcer Bleeding
Recruiting
The primary specific aim is to perform a randomized controlled trial (RCT) to compare rates of delayed hemorrhage after DEP detection of arterial blood flow and focal treatment in PPIU's (treatment arm) with standard treatment using medical guidelines alone (controls) for prevention of delayed bleeding in high risk patients (on anti-coagulants or anti-platelet drugs or with large ulcers) after snare resection of benign colon polyps.
Gender:
ALL
Ages:
35 years and above
Trial Updated:
03/28/2025
Locations: Kaiser Permanente-Downey Medical Center, Downey, California
Conditions: Delayed Post-Polypectomy Induced Ulcer Hemorrhage
Use of Acthar in Rheumatoid Arthritis (RA) Related Flares
Recruiting
This is a Rheumatoid Arthritis (RA) study. The purpose of this research study is to determine in RA flare, whether musculoskeletal ultrasound (MSUS) inflammatory scores and/or disease activity scores improve with Acthar treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, California
Conditions: Rheumatoid Arthritis (RA)
Better Breaks: Strength Breaks vs Walk Breaks for Sedentary Behavior Breaks
Recruiting
This study investigates the benefits of two different types of 2 minute activity breaks during sedentary workdays for people who sit for long periods of time in sedentary jobs.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
03/27/2025
Locations: Stanford Prevention Research Center, Palo Alto, California
Conditions: Sedentary Employees
North American Comfilcon A Clinical Study
Recruiting
The main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon A Sphere, Toric, Multifocal, Toric Multifocal and Energys lenses, when used in the general population.
Gender:
ALL
Ages:
Between 8 years and 75 years
Trial Updated:
03/27/2025
Locations: University of Berkeley, Berkeley, California
Conditions: Astigmatism, Presbyopia, Ametropia
TTVR STRONG Under Coverage With Evidence Development (CED) Study
Recruiting
This Coverage with Evidence Development (CED) study measures the long-term health outcomes of patients with severe, symptomatic Tricuspid Regurgitation who received a Transcatheter Tricuspid Valve Replacement procedure using the EVOQUE system.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/27/2025
Locations: Edwards Lifesciences, Irvine, California
Conditions: Tricuspid Regurgitation
Pilot Feasibility Trial of HEALthy Beginnings for Middle-Aged, and Older Homeless Women
Recruiting
This is a mixed methods pilot feasibility trial of HEALthy Beginnings, an innovative, nurse-driven intervention. Middle-aged and older, homeless women (MAO-HW) will participate in the HEALthy Beginnings intervention and select MAO-HW will be invited to participate in post-intervention qualitative focus groups to evaluate the program.
Gender:
FEMALE
Ages:
40 years and above
Trial Updated:
03/27/2025
Locations: Downtown Women's Center, Los Angeles, California
Conditions: Homelessness, Health Promotion, Chronic Disease Self-care, Multimorbidity, Unhoused
Chronobiological Basis of Menopausal Depression: Correcting Misaligned Circadian Rhythms With Sleep and Light Interventions
Recruiting
The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of m... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California San Diego Hillcrest Medical Center, San Diego, California
Conditions: Depression, Depression During the Menopausal Transition, Menopausal Depression
A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 (Sirolimus) Topical Gel 3.9% in the Treatment of Cutaneous Venous Malformations
Recruiting
A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX022 (sirolimus) Topical Gel 3.9% in the Treatment of Cutaneous Venous Malformations
Gender:
ALL
Ages:
6 years and above
Trial Updated:
03/27/2025
Locations: Children's Hospital of Orange County, Irvine, California
Conditions: Cutaneous Venous Malformations
Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals With Eating Disorders
Recruiting
The goal of this clinical trial is to learn if a new intervention (Promoting Resilience to Improve Disordered Eating; PRIDE) can decrease internalized stigma and increase the ability to cope effectively with stressors in sexual minority populations diagnosed with eating disorders. The main question it aims to answer is: Will an eating disorders treatment focused on decreasing internalized stigma and increasing sexual minority stress coping self efficacy in sexual minority populations? Participa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/27/2025
Locations: San Diego State University, San Diego, California
Conditions: Eating Disorders, Sexual Minorities
The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health
Recruiting
Recently a dietary recommendation of 400 - 600 mg/ day has been proposed for the reduced risk of developing cardiovascular disease. Dietary flavanols can be obtained from the intake of foods such as tea, cocoa, wine, berries and apples. Incorporating Chardonnay Marc (the skins and seeds of Chardonnay grapes) into the diet can be an additional source of dietary flavanols. Like other flavanol-rich foods, Chardonnay Marc provides fiber and polysaccharides that may benefit gut health. This study see... Read More
Gender:
FEMALE
Ages:
Between 45 years and 70 years
Trial Updated:
03/27/2025
Locations: University of California, Davis, Davis, California
Conditions: Cardiovascular Diseases, Adiposity, Cardiometabolic Syndrome
A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
Recruiting
The purpose of the study is to investigate the long-term safety and tolerability of brivaracetam in study participants with childhood absence epilepsy or juvenile absence epilepsy.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/27/2025
Locations: Ep0224 50639, Orange, California
Conditions: Childhood Absence Epilepsy, Juvenile Absence Epilepsy
Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis
Recruiting
This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD). The primary objectives of this pilot trial are to determine the feasibility and safety of conducting a full-scale multi-center randomized controlled trial.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
03/27/2025
Locations: Olive View - UCLA Medical Center, Sylmar, California
Conditions: Pyelonephritis Acute