California is currently home to 5590 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers
Recruiting
The purpose of this clinical trial is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). The prospective randomized, double-blinded, sham-controlled trial is designed to demonstrate superiority of wound closure of the COMS One device to a sham-control device through 24 weeks post-application, when each is administered in conjunction with standard of care (SOC) in the treatment of DFUs.
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
03/27/2025
Locations: Center for Clinical Research Inc., Castro Valley, California
Conditions: Diabetic Foot Ulcer
Aesthetic Outcome of Tie-over Bolster Application in Surgical Wounds
Recruiting
When patients have surgery on the head and face, stitches are the standard way to close the wound. Wounds always result in a scar, but doctors are always looking for ways to reduce scarring. Several studies have been done to test ways to close wounds that reduce scarring. One idea is to reduce the tension around the cut. One way to reduce tension is to stitch a small piece of a special gauze over the top of the regular stitches. This procedure is called a "tie-over bolster dressing." As the name... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California, Davis - Dermatology Department, Sacramento, California
Conditions: Scarring
Family, Responsibility, Education, Support, and Health for Families With a Child With Autism
Recruiting
The objective of this proposed study is to collect initial efficacy data on a telehealth parent-based behavioral program for children with autism and overweight or obesity (PBT-A), compared with health education (HE).
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
03/27/2025
Locations: UC San Diego Center for Healthy Eating and Activity Research (CHEAR), La Jolla, California
Conditions: Autism Spectrum Disorder, Obesity, Childhood, Autism
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy
Recruiting
This phase III trial compares the effect of 3 study approaches in preventing chemotherapy-induced peripheral neuropathy: 1) cryocompression, 2) continuous compression, and 3) low cyclic compression. Taxane chemotherapy drugs, such as paclitaxel or docetaxel, can cause a nerve disorder called peripheral neuropathy, which can cause numbness, tingling, or pain in the arms and legs. The 3 study approaches will use a device, called the Paxman Limb Cryocompression System, made of wraps that cool and/o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Contra Costa Regional Medical Center, Martinez, California
Conditions: Malignant Solid Neoplasm
Chardonnay Marc and Vascular Response
Recruiting
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food... Read More
Gender:
MALE
Ages:
Between 30 years and 50 years
Trial Updated:
03/27/2025
Locations: Academic Surge, University of California, Davis, Davis, California
Conditions: Cardiovascular Diseases, Vascular Dilation, Oxidative Stress
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
Recruiting
The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID. The study will include individuals with confirmed SARS-CoV-2 infection, symptoms not present prior to COVID-19 that are persistent for at least 3 months after acute infection ("Long COVID"), and who have reduced exercise capacity less than predicted and reduced heart rate response during cardiop... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Long COVID, COVID-19
Immunomodulatory Effects of Fasting in Healthy Adults
Recruiting
This is a clinical trial assessing the effects of fasting on the immune system in healthy adults. Immune profiling, gene expression profiling, and flow cytometry on peripheral blood mononuclear cells (PBMCs) will be performed and we hypothesize that a period of fasting will alter the immune system in healthy adults.
Gender:
ALL
Ages:
Between 20 years and 40 years
Trial Updated:
03/27/2025
Locations: UC Davis, Sacramento, California
Conditions: Fasting
Tumescence in HNC Skin Graft Reconstruction
Recruiting
Our primary objective is to determine if the use of tumescence has a meaningful effect on STSG uptake at the recipient site. This is an important outcome because poor graft uptake results in the need for prolonged local wound care, additional clinic visits for patients and increased risk of infection. A prospective, randomized comparison of the tumescence to our current standard of care will allow us to definitively evaluate any benefits to this technique. Tumescence is commonly used in the tre... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UC Davis Health, Sacramento, California
Conditions: Head and Neck Cancer, Surgery--Complications, Graft Failure
Trial of Ixazomib for Kaposi Sarcoma
Recruiting
This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UC San Diego, San Diego, California
Conditions: Kaposi Sarcoma, Skin
Utilization of Negative Pressure Suction to Reduce Aspiration in Oropharyngeal Dysphagia
Recruiting
This is an investigator initiated prospective study to determine whether the use of a negative pressure suction in the hypopharynx will reduce the amount of aspiration during Video Fluoroscopic Swallowing Exam (VFSE) among patients with oropharyngeal dysphagia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Oropharyngeal Dysphagia
International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)
Recruiting
This is an international phase III trial, with a Bayesian design, incorporating two sequential randomisations. It efficiently examines a series of questions that routinely arise in the sequencing of treatment. The study design has evolved from lengthy international consultation that has enabled us to build consensus over which questions arise from current knowledge and practice. It will enable potential randomisation for the majority of patients with inguinal lymph node metastases and will provi... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Los Angeles County-USC Medical Center, Los Angeles, California
Conditions: Squamous Cell Carcinoma of the Penis, Usual Type
Comparison of New SUREcore Biopsy of Needle to Standard of Care During Transperineal Prostate Biopsies
Recruiting
To study a novel biopsy needle system for performing transperineal prostate biopsy. Prostate biopsy remains the standard approach for prostate cancer detection. While pre-biopsy MRI allows for targeting of visible lesions, systemic or 'off target' samples are recommended due to the well-recognized risk of undegrading and under sampling with current commercially available needles. The SureCore plus single-use biopsy needle produces a more intact tissue core with a same caliber 18g needle with \~2... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: UC Davis Departments of Urologic Oncology, Sacramento, California
Conditions: Prostate Cancer