California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Recruiting
This study is a double-blind, randomized, prospective, placebo-controlled single-center clinical research study in which 600 mg of gabapentin or placebo will be administered 2 hours preoperatively to 49 patients each undergoing wisdom teeth extraction. We will measure intraoperative opioid use, severity of pain, the number of analgesics taken, and side effect profiles (e.g. nausea/vomiting, dizziness) at the following intervals, 4 hour, 8 hour, 12 hour, 24, and 72 hour post-procedure.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
04/03/2025
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Dental Pain and Sensation Disorder, Pain, Postoperative
A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)
Recruiting
This is a single-arm, non-randomized, open-label Phase 2 therapeutic study that will assess the effects of adding BPM31510 onto a conventional treatment framework of RT and concurrent TMZ chemotherapy for subjects with newly diagnosed glioblastoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Glioblastoma, Glioblastoma Multiforme
Clinical Translation of a Novel Brain PET Insert for Simultaneous PET/MR
Recruiting
The primary goal of this project is to study the feasibility of a brain-dedicated PET insert for an MR scanner for simultaneous acquisition of PET/MR images of human brains. The study will also allow us to compare the imaging performance of the investigator's brain-dedicated PET insert against a commercial whole-body permanently integrated PET/MRI system using a common radiopharmaceutical.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/03/2025
Locations: Stanford University, Palo Alto, California
Conditions: Brain Disease
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Recruiting
This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual approach to monitoring disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Kaiser Permanente-Anaheim, Anaheim, California
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Positive, Prognostic Stage IV Breast Cancer AJCC v8, Elevated CA15-3 or CEA or CA27-29
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
Recruiting
The study will explore the effects of early intensive antiretroviral therapy (ART) with or without a broadly neutralizing antibody (bNAb) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among infants living with HIV.
Gender:
ALL
Ages:
48 hours and below
Trial Updated:
04/03/2025
Locations: 4601, University of California, San Diego Clinical Research Site, La Jolla, California
Conditions: HIV Infection
Sacroiliac (SI) Joint Transfixing and Fusion: Meaningful Long Term Outcomes With Nevro1
Recruiting
The goal of this observational study is to learn if Nevro1 Sacroiliac Transfixing and Fusion System can treat sacroiliac joint dysfunction in males or females over 21. The main questions it aims to answer is what percentage of patients have clinically important pain relief with no adverse events, and what proportion of patients have fusion of the sacroiliac joint at 1 year and 2 years.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/02/2025
Locations: AIRS Clinic, Lodi, California
Conditions: Sacroiliac Joint Dysfunction
A Study to Investigate Pharmacokinetics (PK) and Safety of a Single Dose of Mavorixafor in Participants With Hepatic Impairment (HI) Compared to Matched Healthy Volunteers With Normal Hepatic Function
Recruiting
The purpose of this study is to measure the effect of HI on the PK, safety, and tolerability of a single dose of mavorixafor compared to matched healthy volunteers (HVs) with normal hepatic function.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/02/2025
Locations: Catalina Research Institute, LLC, Montclair, California
Conditions: Hepatic Insufficiency
Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence
Recruiting
This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after conservative care. The Primary Aim is to determine the comparative effectiveness (as defined by "much" or "very much" better on PGI-I) of transurethral bulking agent (TBA) \[for 1 or 2 injections in 12 months\] vs. single-incision sling (SIS) 12 months after treatment interventio... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/02/2025
Locations: University of California at San Diego, La Jolla, California
Conditions: Stress Urinary Incontinence, Urinary Incontinence, Mixed Urinary Incontinence
Multi-Omics for Maternal Health After Preeclampsia
Recruiting
To develop strategies to identify postpartum women at risk for adverse cardiovascular outcomes and provide them with preventative therapies.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/02/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Pre-Eclampsia, Pregnancy Induced Hypertension
Genomic Sequencing in Anatomically Normal Fetuses
Recruiting
This cohort study will examine the clinical utility of genomic sequencing (GS) in patients undergoing prenatal diagnostic procedures (chorionic villus sampling or amniocentesis) for routine indications other than a structural fetal anomaly.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/02/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Pregnant Individuals Requesting Standard Microarray
Aveir AR Coverage With Evidence Development (CED) Study
Recruiting
The purpose of this coverage with evidence development (CED) study is to evaluate complications and long-term health outcomes of the single-chamber Aveir Atrial Leadless Pacemaker device (aka Aveir™ AR LP system).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Abbott, Sylmar, California
Conditions: Cardiac Pacemaker, Arrhythmia, Bradycardia
Preschool Hearing Screening
Recruiting
Children who are deaf or hard-of-hearing (D/HH) are at risk of speech and language delays, which can be mitigated through early identification and intervention. Identifying hearing loss (HL) during preschool is crucial, but the most effective hearing screening method for preschoolers remains uncertain. The purpose of this study is to learn whether, compared to the gold-standard two-stage Pure-tone audiometry (PTA) + otoacoustic emissions (OAE) screening (TS-PO), single-stage OAE (SS-O) screening... Read More
Gender:
ALL
Ages:
Between 2 years and 6 years
Trial Updated:
04/02/2025
Locations: The University of California, San Francisco, San Francisco, California
Conditions: Hearing Loss, Hearing Disorders in Children, Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Unilateral, Hearing Loss, Noise-Induced, Hearing Loss, Mixed, Hearing Loss, Bilateral