California is currently home to 5952 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies
Recruiting
The primary objective of this study is to prospectively evaluate rate of post-operative ileus or obstruction in patients with ileostomies receiving low fiber diet vs. regular diet starting post-operative day 1. The secondary objectives of this study are to compare the 30-day and 90-day readmission rates, length of stay, rate of high stoma output or need for antidiarrheals within 90 days, nausea score, level of pain, and overall quality of life amongst the patients studied.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
10/20/2022
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Ileostomy; Complications, Bowel Obstruction, Postoperative Ileus
CERENOVUS Neurothrombectomy Devices Registry
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Vascular Neurology of Southern California: Dr. M. Asif Taqi, Thousand Oaks, California
Conditions: Cerebral Stroke
A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD
Recruiting
This randomized, double-blind, placebo-controlled trial of doxazosin will assess doxazosin's effectiveness for PTSD nightmares, subjective sleep quality, and non-nightmare PTSD symptoms in adult men and women veterans with full and partial-syndromal PTSD.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/19/2022
Locations: San Francisco VA Medical Center, San Francisco, California
Conditions: Stress Disorders, Post-Traumatic
Efficacy of Using Mobile Health Applications for Health
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and type II diabetes outcomes in type 2 diabetics. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the same time, and check their blood glucose readings daily before and after meals for at least three meals in the day.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
10/18/2022
Locations: San Diego State University, San Diego, California
Conditions: Diabetes Mellitus, Type 2, Obesity
Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension
Recruiting
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients. Several trials suggest triple low-dose combination therapy may be highly effective in terms of achieving blood pressure control without increasing adverse effects. This trial is designed to investigate the efficacy and safety of GMRx2 in participants with high blood pressure compared to dual combinations.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2022
Locations: Valiance Clinical Research, S. Gate, California
Conditions: Hypertension
Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th Salvage
Recruiting
Phase III, multicenter, randomized study with two arms (1:1 ratio) enrolling patients with AML relapsed/refractory after 2, 3, or 4 prior induction regimens: Experimental arm: DFP-10917 14-day continuous intravenous (IV) infusion at a dose of 6 mg/m²/day followed by a 14-day resting period per 28-day cycles. Control arm: Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High and Intermediate Dose Cytarabine Regimens), dependin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2022
Locations: University of California, Irvine, California
Conditions: Leukemia, Myeloid, Acute
MRI and PET Biomarkers for Cognitive Decline in Older Adults
Recruiting
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to this study includes additional PET scans to examine the relationship between tau protein in the brain and cognitive decline. Tau is a protein that is known to form tangles in the areas of the brain import... Read More
Gender:
All
Ages:
Between 60 years and 105 years
Trial Updated:
10/18/2022
Locations: University of California, Irvine, Irvine, California
Conditions: Alzheimer Disease, Cognitive Impairment, Cognitive Decline
Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers
Recruiting
The goal of this clinical trial is to determine the safety of DERMASEAL for the treatment of non-healing, neuropathic diabetic foot ulcers. The main outcome measure is safety. A total of twenty-four (24) participants will be randomized to receive up to four (4) consecutive weeks of treatment with either standard of care (SOC), plasma film + SOC, or plasma film containing silver microparticles (DERMASEAL) + SOC, with a final follow-up visit 12 weeks after the last treatment.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/16/2022
Locations: Limb Preservation Platform, Inc., Fresno, California
Conditions: Foot Ulcer, Diabetic
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and the subsequent benefit of improving type II diabetes outcomes in a low socioeconomic Hispanic population. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the same time, and check their blood glucose readings daily before and after meals for at least three meals in the day.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
10/16/2022
Locations: San Diego State University, San Diego, California
Conditions: Diabetes Mellitus, Type 2, Obesity
Pilot Trial of the Nutrition-Supported Diabetes Education Program
Recruiting
This is a pragmatic, pilot randomized controlled trial (RCT) of the Nutrition-Supported Diabetes Education Program (NU-DSMP). This study will test the feasibility and preliminary impact of providing diabetes-tailored food support and individualized case-management on glycemic control and other intermediate outcomes including food security, diet, mental health, and health care behaviors, among Medicaid-enrolled patients with type 2 diabetes in a safety-net county health system.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/14/2022
Locations: Contra Costa Health Services, Martinez, California
Conditions: Diabetes Mellitus, Type 2
Treatment of Meniere's Disease With Migraine Medications
Recruiting
Meniere's disease (MD) is a chronic disease with a variety of fluctuating signs and symptoms, which include vertigo, hearing loss, tinnitus (ringing noise in the ear), aural pressure (feeling of ear fullness), and disequilibrium (lack of stability). Vertigo represents one of the most common and distressing problems in MD patients, and it causes various somatic and psychological disorders that interfere with the patient's quality of life. Despite the large economic and emotional impact of symptom... Read More
Gender:
All
Ages:
Between 25 years and 85 years
Trial Updated:
10/12/2022
Locations: University of California, Irvine Medical Center ENT Clinic (Pavilion 2), Orange, California
Conditions: Ménière
Evaluating How Course Modality Influences the Effectiveness of the R3 Academy for Dads
Recruiting
The Cal-FIRE project is designed to offer the R3 Academy for Dads, a robust 24-hour program, to predominantly low-income adult fathers, ages 18 and over in the state of California. The R3 Academy is an evidence-based parenting curriculum that helps fathers strengthen their relationships with their child, with their spouse/co-parent, and at work. The program also includes two evidence-based components that address economic stability and an innovative approach to Case Management that fosters clien... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
10/12/2022
Locations: Healthy Relationships California, Leucadia, California
Conditions: Program Modality