California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MCT for the Harvard/UCSF ROBIN Center
Recruiting
The goal of the Molecular Characterization Trial (MCT) is to obtain biological specimens and data resources from patients enrolled on prospective trials, to ensure that the Harvard/UCSF ROBIN Center accomplishes its key objective of advancing our understanding of the biological mechanisms that underlie how radiation treats tumors but also can cause unwanted side effects. The MCT focuses on collection of research biospecimens before, during, and after radiation. Also critical to the MCT is the de... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/13/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Glioma, Childhood Brainstem, Neuroblastoma
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans with Severe Posttraumatic Stress Disorder
Recruiting
In partnership with the Veterans Affairs (VA) Palo Alto Health Care System and Stanford University, this study aims to evaluate clinical outcomes, assess implementation feasibility, and health economics of MDMA-assisted Cognitive Processing Therapy (MDMA-aCPT) in the treatment of posttraumatic stress disorder (PTSD). Through a randomized comparison of MDMA-aCPT versus Cognitive Processing Therapy (CPT), a VA gold standard treatment for PTSD, the proposed study will set the stage for understandin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: VA Palo Alto Health Care System / Stanford University, Palo Alto, California
Conditions: PTSD
REBYOTA™ Prospective Registry
Recruiting
This is a prospective observational cohort study designed to collect data on patients who received REBYOTA™ for the prevention of rCDI in the routine care setting. As all data collected for this study are observational, the decision to prescribe REBYOTA™ is at the treating physician's discretion and independent from the decision to enroll the patient in the study. Data will be collected from patients' medical records after obtaining informed consent. Data about clinical history, CDI events (prim... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Ferring Investigational Site, Chula Vista, California
Conditions: Recurrence of Clostridium Difficile Infection
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study
Recruiting
The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowering glaucoma medications are used to treat glaucoma. A total of up to 188 participants will be enrolled and randomized 1:1 to receive N\&P or placebo for 87 weeks (20 months). Participants will be followed for a total of 91 weeks (21 months).
Gender:
ALL
Ages:
Between 35 years and 85 years
Trial Updated:
02/13/2025
Locations: Stanford University Department of Ophthalmology, Palo Alto, California
Conditions: Primary Open Angle Glaucoma
Geriatric Evaluation and Management with Survivorship Health Education (GEMS) for Older Survivors of Cancer
Recruiting
This phase III cluster randomized trial compares the effect of geriatric evaluation and management with survivorship health education (GEMS) to usual care on patient-reported physical function in older survivors of cancer. Survivorship care for older adults of cancer usually consists of getting advice from their doctor. This advice may include how to do their daily activities, so they are less tired or how to manage multiple diseases, or long-term side effects from treatment. GEMS may help impro... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/13/2025
Locations: Kaiser Permanente NCORP (KAISER), Vallejo, California
Conditions: Malignant Solid Neoplasm
DBT Skills Groups for Veterans at High Risk for Suicide Attempt
Recruiting
Veteran suicide death is a national crisis. Risk factors include emotion dysregulation, which occurs across mental health disorders. Dialectical behavior therapy (DBT) is an evidence-based suicide intervention that targets emotion dysregulation but is resource-intensive and not widely available at VHA. A more efficient evidence-based DBT Skills Group (DBT-SG) is associated with reduced suicidal ideation and emotion dysregulation and likely more feasible to implement at VHA. This is a randomized... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Suicide, Attempted
Cefixime Clinical Trial
Recruiting
This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Syphilis, Human Immunodeficiency Virus
Allograft Dysfunction in Heart Transplant
Recruiting
The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: UC San Diego, La Jolla, California
Conditions: Heart Transplant Failure and Rejection
A Phase 2 Study of MZE829 in Adults with APOL1 Kidney Disease
Recruiting
This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/12/2025
Locations: Amicis Research Center, Fairfield, California
Conditions: Proteinuric Kidney Disease
At-Home Cardiac Rehabilitation for Adolescents At Risk for Heart Failure
Recruiting
The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer are * To evaluate the efficacy of an at-home CORE model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors. * To evaluate the exercise adherence rate among adolescents at risk for heart failure and assess... Read More
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
02/12/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Cardiovascular Complication, Chemotherapeutic Toxicity
A Phase 2, Open-label, Single-arm Study of Autologous M-CENK Adoptive Cell Therapy and N-803 (IL-15 Superagonist) in Combination with Gemcitabine in Participants with Recurrent Platinum-Resistant High-Grade Ovarian Cancer
Recruiting
This is phase 2 single arm study evaluating the safety and preliminary efficacy of M-CENK adoptive cell therapy and fixed dose of N-803 in combination with gemcitabine in participants with platinum-resistant high-grade ovarian cancer (HGOC).Up to 20 participants will receive M-CENK (IV) and N-803 (SC) in combination with gemcitabine (IV). Participants will undergo an apheresis procedure for the collection of mononuclear cells (MNCs) at least 1 day prior to Cycle 1 for manufacturing of M-CENK. S... Read More
Gender:
FEMALE
Ages:
Between 18 years and 85 years
Trial Updated:
02/12/2025
Locations: Chan Soon-Shiong Institute for Medicine, El Segundo, California
Conditions: Platinum-resistant Ovarian Cancer
Bone Mineral Density Agreement Study Between EOSedge™ Versus Traditional DXA
Recruiting
The purpose of this research is to collect medical imaging data to allow for the comparison of bone mineral density measurements from two different types of low-dose x-ray exams, EOSedge and conventional DXA. The main question it aims to answer is: Is there agreement between the calculated T-scores between the 2 different types of x-ray exams?
Gender:
ALL
Ages:
20 years and above
Trial Updated:
02/12/2025
Locations: ATEC Carlsbad, Carlsbad, California
Conditions: Healthy, Indicated for EOSedge Imaging