California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment
Recruiting
This is a Phase 2, randomized two-armed, multi-site study of 170 patients with newly diagnosed glioblastoma multiforme. Patients will be randomized 1:1 to receive Keto Diet, or Standard Anti-Cancer Diet. All patients will receive standard of care treatment for their glioblastoma. The Keto Diet intervention will be for an 18-week period and conducted by trained research dietitians. Daily ketone and glucose levels will be recorded to monitor Keto Diet adherence. This two-armed randomized multi-si... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Glioblastoma Multiforme
Study of Oral MRT-2359 in Selected Cancer Patients
Recruiting
This Phase 1/2, open-label, multicenter study is conducted in patients with previously treated selected solid tumors, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), high-grade neuroendocrine cancer of any primary site, diffuse large B-cell lymphoma (DLBCL), and tumors with L-MYC or N-MYC amplification. Patients receive escalating doses of a GSPT1 molecular glue degrader MRT-2359 to determine safety, tolerability, maximum tolerated dose (MTD) and/or recommended Phase... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2025
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: NSCLC, SCLC, DLBCL, NSCLC With High or Low L-MYC or N-MYC Expression, High Grade Neuroendocrine Cancer, L-MYC and N-MYC Amplified Solid Tumors, HR-positive, HER2-negative Breast Cancer, Prostate Cancer
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
Recruiting
This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation. Such knowledge may inform future strategies for treating brain disease and inflammation. Participants will be randomly assigned to one of two groups, both of which will receive the same treatment in a different order over a period of about 6 weeks. The visits include physical examinations, blood tests, and other procedures d... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
02/14/2025
Locations: HIV Neurobehavioral Research Program (HNRP), San Diego, California
Conditions: Hiv, Cannabis, THC, Neuroinflammatory Disease, Neuroinflammatory Response, Microbiome
Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain
Recruiting
As a leading cause of disability worldwide, chronic low back pain (cLBP) represents a significant medical and socioeconomic problem with estimated health care spending of $87 billion/annually. The efficacy of dorsal column electrical stimulation to inhibit pain was first described over 50 years ago. Since then, several large clinical trials have investigated the therapeutic potential of electrical spinal cord stimulation (SCS) and found that over 70% of patients with intractable pain had over 50... Read More
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
02/14/2025
Locations: San Francisco VA Medical Center, San Francisco, California
Conditions: Chronic Low-back Pain
Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
Recruiting
Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
02/14/2025
Locations: Stanford University, Stanford, California
Conditions: Autism Spectrum Disorder, Autism, Asperger Syndrome
DBS of the SCC for the Treatment of Medically Refractory CLBP
Recruiting
The purpose of this study is to evaluate the feasibility and preliminary efficacy of deep brain stimulation of the subgenual cingulate cortex for the treatment of chronic medically-refractory low back pain using a randomized double-blind crossover design.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
02/14/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Chronic Low-back Pain
Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery
Recruiting
This phase I/II trial studies the best dose and timing of panitumumab-IRDye800 in detecting cancer in participants with lung cancer during the surgery. Panitumumab-IRDye800 is a combination of the antibody drug panitumumab and IRDye800CW, an investigational dye that can be seen using a special camera. Panitumumab-IRDye800 may attach to tumor cells and make them more visible during surgery in patients with lung cancer.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
02/14/2025
Locations: Stanford University, School of Medicine, Palo Alto, California
Conditions: Lung Carcinoma, Metastatic Malignant Neoplasm in the Lung, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
Recruiting
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/14/2025
Locations: Regents of the University of California San Francisco, San Francisco, California
Conditions: Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery
Recruiting
This phase I/II trial studies the side effects and best dose of panitumumab-IRDye800 and to see how well it works in finding cancer in patients with pancreatic cancer who are undergoing surgery. Panitumumab-IRDye800 is a combination of the antibody drug panitumumab and IRDye800CW, an investigational dye that can be seen using a special camera. Panitumumab-IRDye800 may attach to tumor cells and make them more visible during surgery in patients with pancreatic cancer.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
02/14/2025
Locations: Stanford University, School of Medicine, Palo Alto, California
Conditions: Pancreatic Adenocarcinoma
Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas
Recruiting
Osteoid osteomas are painful, benign bone tumors that occur most frequently in young males between ages 10 and 20 years. The goal of the proposed study is based on the premise that MRgFUS is noninferior to CT-guided radiofrequency ablation (CTgRFA), in terms of pain reduction following treatment of osteoid osteomas, and offers possible improvements with regards to 1) post-procedural pain, 2) clinical resource utilization, 3) patient experience, and/or 4) adverse events. The data from the current... Read More
Gender:
ALL
Ages:
8 years and above
Trial Updated:
02/14/2025
Locations: Stanford Medical Center, Palo Alto, California
Conditions: Osteoid Osteoma
A Phase 3 Study of UGN-103 for Treatment of Patients With Low-grade Intermediate-risk Non-muscle Invasive Bladder Cancer
Recruiting
This Phase 3, single-arm, multicenter study will evaluate the efficacy and safety of UGN-103, a novel formulation of UGN-102, instilled in the urinary bladder of patients with low-grade non-muscle invasive bladder cancer (LG-NMIBC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Genesis Research, LLC, San Diego, California
Conditions: Bladder Cancer, Urothelial Carcinoma, Urothelial Carcinoma Bladder
Advance Care Planning With Formerly Homeless Older Adults Residing in Permanent Supportive Housing
Recruiting
The homeless population is aging, with an increasing proportion of individuals over age 50 who experience accelerated aging, high rates of mortality, and a high risk of not having their wishes honored at the end of life. The goal of this randomized control trial (RCT) is to test the effectiveness of adapted evidence-based advance care planning (ACP) interventions for formerly chronically homeless older adults living in permanent supportive housing (PSH).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/13/2025
Locations: Abode Services, Fremont, California
Conditions: Advance Care Planning