California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Type 1 Diabetes Extension Study
Recruiting
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study will: * follow participants to determine how long they continue to produce insulin, and * will also assess how changes in the immune system over time relate to the ability to produce insulin. This information could help design better therapies for... Read More
Gender:
ALL
Ages:
Between 8 years and 35 years
Trial Updated:
04/09/2025
Locations: UCSF School of Medicine, San Francisco, California
Conditions: Type 1 Diabetes Mellitus, T1DM, T1D
Evaluation of the Safety, Tolerability and Pharmacokinetics of AH-001 Following Topical Single and Multiple Ascending Dose Administration
Recruiting
The goal of this clinical trial is to assess the safety of the AH-001 drug substance at concentrations of 0.2%, 0.5%, 1%, and 2% in healthy volunteers and male subjects with androgenetic alopecia (AGA). Primary objective: * To evaluate the safety, tolerability, and pharmacokinetics profiles of a single ascending dose (SAD) of AH-001 in healthy volunteers. * To evaluate the safety, tolerability, and pharmacokinetics profiles of multiple ascending doses (MAD) of AH-001 in male subjects with andr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Inc., Los Angeles, California
Conditions: Androgenetic Alopecia
Study to Evaluate Safety, Tolerability and Pharmacokinetics of IDB-011
Recruiting
Phase 1 randomized, double-blind, placebo-controlled trial to evaluate safety, tolerability, pharmacokinetics (PK) and immunogenicity of IDB-011 following intramuscular (IM )administration of single ascending doses to healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Cypress, California
Conditions: Rift Valley Fever
Emgality for Migraine in Breastmilk
Recruiting
The goal of this project is to evaluate galcanezumab transfer into maternal breastmilk, and to evaluate infant (growth, development, constipation, colic, infections) and maternal (headache) outcomes for dyads in which the mother was treated with galcanezumab and to compare outcomes for infants who were or were not breastfed after maternal treatment. In this prospective observational study, the study team proposes to prospectively collect serial milk samples from 30 adult women who are treated w... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/04/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Migraine
Family Mental Health Family Navigator Project (FMHN)
Recruiting
This study will focus on developing and testing a family-based mental health navigator intervention, the Family Mental Health Navigator (FMHN), to evaluate whether the intervention combined with mHealth is preliminary efficacious in improving mental health service initiation and engagement for publicly-insured youth.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
04/04/2025
Locations: UCSF Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Mental Health
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Recruiting
The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocar... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
Safety Study for Prospective Assessment of Pregnancy Outcomes in Patients Treated With Tildrakizumab
Recruiting
This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to tildrakizumab during pregnancy to treat an approved indication. The pregnancy registry cohort study will be conducted by the Organization of Teratology Information Specialists (OTIS), which is a network of university and health department based information centers serving pregnant women and healthcare providers throughout North America. Th... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
04/04/2025
Locations: Christina Chambers, San Diego, California
Conditions: Pregnancy Related
YAG Laser Vitreolysis for Vitreous Floaters
Recruiting
The purpose of this study is to measure how the quality of life, the structure of eye, and vision change after treatment for the opacities in the gel (vitreous) that fills the center of eye which cause vision disturbances commonly called "floaters". In this study the vitreous floaters are treated using a Neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser. The FDA has approved the use of this laser to treat membranes in the eye.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: VMR Institute for Vitreous Macula Retina, Huntington Beach, California
Conditions: Posterior Vitreous Detachment, Myopic Vitreopathy, VISION DEGRADING MYODESOPSIA
A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:
Recruiting
The objective of this clinical study is to demonstrate that ablation with the TactiFlex SE Ablation catheter, in conjunction with a compatible pulsed field ablation (PFA) and/or radio frequency (RF) generator, is safe and effective for the treatment of symptomatic, recurrent, drug refractory paroxysmal atrial fibrillation (PAF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Stanford University Medical Center, Stanford, California
Conditions: Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
Developing a Nutritional Supplement to Increase Collagen Synthesis in People
Recruiting
The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samp... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/03/2025
Locations: Hickey Laboratory, Davis, California
Conditions: Dietary Supplements, Connective Tissue, Exercise
Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial
Recruiting
The Short-Cut trial is a prospective, investigator-initiated, multicenter, randomized controlled trial that is designed to compare the efficacy of cutting balloon angioplasty vs. intravascular lithotripsy prior to drug-eluting stent implantation in patients with moderate to severely calcified coronary arteries.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/03/2025
Locations: UCSF Cardiology, San Francisco, California
Conditions: Treatment in Calcified Coronary Disease
AVEIR DR Coverage With Evidence Development (CED) Study
Recruiting
The purpose of this coverage with evidence development (CED) study is to evaluate complications and long-term health outcomes of the dual chamber Aveir Leadless Pacemaker device (aka Aveir™ DR LP system).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Abbott, Sylmar, California
Conditions: Cardiac Pacemaker, Arrythmia, Bradycardia