California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety, Tolerability, and Pharmacokinetics of Lumateperone Long-Acting Injectable Formulations in Patients With Schizophrenia or Schizoaffective Disorder
Recruiting
Study ITI-007-037 is a Phase 1b, open-label study to evaluate the safety, tolerability, and PK of lumateperone long-acting injectable (LAI) formulations after a single intramuscular injection in patients with stale schizophrenia or schizoaffective disorder.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/19/2025
Locations: Clinical Site 2, Los Alamitos, California
Conditions: Schizophrenia or Schizoaffective
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
Recruiting
The primary objective of the THRIVE Pivotal study is to demonstrate the adjunctive effectiveness and the safety of the TIVUS system in: 1. subjects with hypertension (HTN) receiving up to 2 anti-hypertensive drugs of different classes in whom the anti-hypertensive medications will be stopped for a 4-week wash-out period before RDN/Sham procedure and during 2 months after procedure. 2. subjects with controlled hypertension receiving up to 2 anti-hypertensive drugs of different classes and who ac... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/19/2025
Locations: Cedar-Sinai Medical Center, Los Angeles, California
Conditions: Hypertension
Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses
Recruiting
The investigators will test the following hypothesis: Use of Glide results in improved functional performance, satisfaction, and usage metrics as compared to use of a standard Direct Control (DC) prosthesis. This study will compare the use of Glide \[Experimental\] prosthesis with a DC \[Standard\] prosthesis in a clinical setting and in unsupervised daily activity. We will follow a multiple baseline design, specifically an AB design. Each of the subjects will use the Experimental and Standard... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Advanced Arm Dynamics, Redondo Beach, California
Conditions: Amputation, Upper Limb
Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm
Recruiting
This is a single center study investigating the use of Fluoroethyltyrosine (FET) in the detection of brain tumors. FET accumulates in malignant cells within intracranial neoplasms and can be used to detect recurrent disease and characterize grade of glial neoplasms.
Gender:
ALL
Ages:
4 years and above
Trial Updated:
03/19/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Intracranial Neoplasm
Androgens and NAFLD Longitudinal Cohort Study
Recruiting
The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will comp... Read More
Gender:
FEMALE
Ages:
Between 18 years and 42 years
Trial Updated:
03/19/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: PCOS, NAFLD, NASH
Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial
Recruiting
The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream Infection (GN-BSI) is as effective but safer than remaining on intravenous (IV) antibiotic therapy for the duration of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Gram-negative Bacteremia
Assessment of the Interi Manifold in Implant-Based Breast Reconstruction
Recruiting
Patients with breast cancer that elect to undergo implant-based breast reconstruction (IBBR) often require the placement of a surgical drain. Surgical drains are used to manage dead space and prevent seroma formation or accumulation of fluid within the surgical field postoperatively. The most frequently used drain is a Jackson-Pratt (JP) drain, which is limited by poor surgical site coverage and low capacity, leading to inconsistent suction and prolonged time that a drain is left in place. The I... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
03/19/2025
Locations: Stanford Hospital and Clinics, Palo Alto, California
Conditions: Mastectomy, Implant Based Breast Reconstruction
Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate Cancer
Recruiting
This is a single-center, open-label, study of Prostate-Specific Membrane Antigen (PSMA)-targeted radionuclide therapy with 177Lu-PSMA-617 in combination with pembrolizumab in participants with metastatic castrate-resistant prostate cancer (mCRPC) who have previously progressed on at least one prior androgen pathway inhibitor (e.g., abiraterone, enzalutamide, apalutamide).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Castrate Resistant Prostate Cancer, Metastatic Castration-resistant Prostate Cancer, Prostate Cancer, Prostate Carcinoma
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
Recruiting
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine users.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
03/19/2025
Locations: University of California, San Francisco - Tobacco Research Center, San Francisco, California
Conditions: Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
Hyperpolarized 13C MRI As a Biomarker in Advanced Solid Tumors
Recruiting
This is a single center prospective imaging study investigating the utility of hyperpolarized 13C-pyruvate +/-13C,15N-Urea/ metabolic MR imaging. The current protocol will serve as a companion imaging biomarker study paired with standard of care (SOC) therapeutics, as well as investigational therapies that participants may be scheduled to receive outside of this protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Advanced Solid Tumor
Physio-Anatomy Clinical Data Collection Study
Recruiting
This is an on-label clinical study design intended for the collection of three different types of interventional procedural data using FDA-cleared cardiac catheterization technologies and drugs, each used according to its product labeling and standard practice of medicine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Veteran's Administration Palo Alto, Palo Alto, California
Conditions: Coronary Stenosis
Understanding Allergies and Sensitizations in Healthy and Allergic Individuals
Recruiting
The purpose of this study is to strengthen our ability to accurately diagnose allergies and understand cellular, humoral, genetic components and physiological changes in allergic disease
Gender:
ALL
Ages:
Between 1 week and 90 years
Trial Updated:
03/19/2025
Locations: Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, California
Conditions: Allergy