California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study Comparing Local/ MAC Anesthesia in Lumbar Decompression
Recruiting
Explore efficacy, complications, and other factors associated with anaesthetic choice- To evaluate the efficacy of local + MAC as an alternative anesthetic to general anesthesia and to analyze patients' outcomes and experiences.
Gender:
ALL
Ages:
Between 40 years and 95 years
Trial Updated:
04/08/2025
Locations: Outpatient Surgery Center/Stanford Spine Clinic, Redwood City, California
Conditions: Lumbar Spinal Stenosis
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
Recruiting
Fetal complete (i.e., third degree, 3°) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies and results in death in a fifth of cases. To date treatment of 3° AVB has been ineffective in restoring normal rhythm (NR) which may be because current surveillance is limited to once- weekly fetal echocardiograms. It is hypothesized that there may be a vital transition p... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: University of California - Los Angeles (UCLA), Los Angeles, California
Conditions: AVB - Atrioventricular Block, Fetal AVB
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
Recruiting
Assess the safety and tolerability, identify dose-limiting toxicities (DLT) and determine the maximum tolerated dose (MTD) / recommended phase 2 dose (RP2D) of lisaftoclax.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/08/2025
Locations: City of Hope, Duarte, California
Conditions: CLL/SLL
Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery
Recruiting
The primary objective of this study is to prospectively determine, at 10 days after orthopedic shoulder or knee surgery, if pulsed electromagnetic field (PEMF) therapy is beneficial in reducing patient-reported post-operative pain, as measured by visual analog scale (VAS). The amount of pain medication taken daily and the physical function outcome scores after surgery and PEMF treatment will also be measured.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: Stanford University, Redwood City, California
Conditions: Knee Injuries, Shoulder Injuries, Pain, Postoperative
Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients
Recruiting
The purpose of this study is to test any good and bad effects of the study drug called brentuximab vedotin at a lower dose than is FDA-approved.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: Stanford University Medical Center, Stanford, California
Conditions: Mycosis Fungoides, Lymphomatoid Papulosis, Sezary Syndrome
Evaluation of the Safety, Tolerability and Pharmacokinetics of AH-001 Following Topical Single and Multiple Ascending Dose Administration
Recruiting
The goal of this clinical trial is to assess the safety of the AH-001 drug substance at concentrations of 0.2%, 0.5%, 1%, and 2% in healthy volunteers and male subjects with androgenetic alopecia (AGA). Primary objective: * To evaluate the safety, tolerability, and pharmacokinetics profiles of a single ascending dose (SAD) of AH-001 in healthy volunteers. * To evaluate the safety, tolerability, and pharmacokinetics profiles of multiple ascending doses (MAD) of AH-001 in male subjects with andr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Inc., Los Angeles, California
Conditions: Androgenetic Alopecia
Study to Evaluate Safety, Tolerability and Pharmacokinetics of IDB-011
Recruiting
Phase 1 randomized, double-blind, placebo-controlled trial to evaluate safety, tolerability, pharmacokinetics (PK) and immunogenicity of IDB-011 following intramuscular (IM )administration of single ascending doses to healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/07/2025
Locations: Altasciences Clinical Los Angeles, Cypress, California
Conditions: Rift Valley Fever
Emgality for Migraine in Breastmilk
Recruiting
The goal of this project is to evaluate galcanezumab transfer into maternal breastmilk, and to evaluate infant (growth, development, constipation, colic, infections) and maternal (headache) outcomes for dyads in which the mother was treated with galcanezumab and to compare outcomes for infants who were or were not breastfed after maternal treatment. In this prospective observational study, the study team proposes to prospectively collect serial milk samples from 30 adult women who are treated w... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/04/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Migraine
Family Mental Health Family Navigator Project (FMHN)
Recruiting
This study will focus on developing and testing a family-based mental health navigator intervention, the Family Mental Health Navigator (FMHN), to evaluate whether the intervention combined with mHealth is preliminary efficacious in improving mental health service initiation and engagement for publicly-insured youth.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
04/04/2025
Locations: UCSF Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Mental Health
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Recruiting
The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocar... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
Safety Study for Prospective Assessment of Pregnancy Outcomes in Patients Treated With Tildrakizumab
Recruiting
This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to tildrakizumab during pregnancy to treat an approved indication. The pregnancy registry cohort study will be conducted by the Organization of Teratology Information Specialists (OTIS), which is a network of university and health department based information centers serving pregnant women and healthcare providers throughout North America. Th... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
04/04/2025
Locations: Christina Chambers, San Diego, California
Conditions: Pregnancy Related
YAG Laser Vitreolysis for Vitreous Floaters
Recruiting
The purpose of this study is to measure how the quality of life, the structure of eye, and vision change after treatment for the opacities in the gel (vitreous) that fills the center of eye which cause vision disturbances commonly called "floaters". In this study the vitreous floaters are treated using a Neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser. The FDA has approved the use of this laser to treat membranes in the eye.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: VMR Institute for Vitreous Macula Retina, Huntington Beach, California
Conditions: Posterior Vitreous Detachment, Myopic Vitreopathy, VISION DEGRADING MYODESOPSIA