California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
NCT02140255
Recruiting
The study will explore the effects of early intensive antiretroviral therapy (ART) with or without a broadly neutralizing antibody (bNAb) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among infants living with HIV.
Gender:
ALL
Ages:
48 hours and below
Trial Updated:
04/03/2025
Locations: 4601, University of California, San Diego Clinical Research Site, La Jolla, California
Conditions: HIV Infection
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Sacroiliac (SI) Joint Transfixing and Fusion: Meaningful Long Term Outcomes With Nevro1
NCT06909292
Recruiting
The goal of this observational study is to learn if Nevro1 Sacroiliac Transfixing and Fusion System can treat sacroiliac joint dysfunction in males or females over 21. The main questions it aims to answer is what percentage of patients have clinically important pain relief with no adverse events, and what proportion of patients have fusion of the sacroiliac joint at 1 year and 2 years.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/02/2025
Locations: AIRS Clinic, Lodi, California
Conditions: Sacroiliac Joint Dysfunction
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A Study to Investigate Pharmacokinetics (PK) and Safety of a Single Dose of Mavorixafor in Participants With Hepatic Impairment (HI) Compared to Matched Healthy Volunteers With Normal Hepatic Function
NCT06858696
Recruiting
The purpose of this study is to measure the effect of HI on the PK, safety, and tolerability of a single dose of mavorixafor compared to matched healthy volunteers (HVs) with normal hepatic function.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/02/2025
Locations: Catalina Research Institute, LLC, Montclair, California
Conditions: Hepatic Insufficiency
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Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence
NCT06480227
Recruiting
This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after conservative care. The Primary Aim is to determine the comparative effectiveness (as defined by "much" or "very much" better on PGI-I) of transurethral bulking agent (TBA) \[for 1 or 2 injections in 12 months\] vs. single-incision sling (SIS) 12 months after treatment interventio... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/02/2025
Locations: University of California at San Diego, La Jolla, California
Conditions: Stress Urinary Incontinence, Urinary Incontinence, Mixed Urinary Incontinence
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Multi-Omics for Maternal Health After Preeclampsia
NCT06340152
Recruiting
To develop strategies to identify postpartum women at risk for adverse cardiovascular outcomes and provide them with preventative therapies.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/02/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Pre-Eclampsia, Pregnancy Induced Hypertension
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Genomic Sequencing in Anatomically Normal Fetuses
NCT06211348
Recruiting
This cohort study will examine the clinical utility of genomic sequencing (GS) in patients undergoing prenatal diagnostic procedures (chorionic villus sampling or amniocentesis) for routine indications other than a structural fetal anomaly.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/02/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Pregnant Individuals Requesting Standard Microarray
Register for Updates
Aveir AR Coverage With Evidence Development (CED) Study
NCT06100770
Recruiting
The purpose of this coverage with evidence development (CED) study is to evaluate complications and long-term health outcomes of the single-chamber Aveir Atrial Leadless Pacemaker device (aka Aveir™ AR LP system).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Abbott, Sylmar, California
Conditions: Cardiac Pacemaker, Arrhythmia, Bradycardia
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Preschool Hearing Screening
NCT06058767
Recruiting
Children who are deaf or hard-of-hearing (D/HH) are at risk of speech and language delays, which can be mitigated through early identification and intervention. Identifying hearing loss (HL) during preschool is crucial, but the most effective hearing screening method for preschoolers remains uncertain. The purpose of this study is to learn whether, compared to the gold-standard two-stage Pure-tone audiometry (PTA) + otoacoustic emissions (OAE) screening (TS-PO), single-stage OAE (SS-O) screening... Read More
Gender:
ALL
Ages:
Between 2 years and 6 years
Trial Updated:
04/02/2025
Locations: The University of California, San Francisco, San Francisco, California
Conditions: Hearing Loss, Hearing Disorders in Children, Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Unilateral, Hearing Loss, Noise-Induced, Hearing Loss, Mixed, Hearing Loss, Bilateral
Register for Updates
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
NCT05962229
Recruiting
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
04/02/2025
Locations: Zuckerberg San Francisco General Hospital (ZSFG), San Francisco, California
Conditions: Nicotine Dependence, Nicotine Vaping
Register for Updates
Aveir DR Real-World Evidence Post-Approval Study
NCT05935007
Recruiting
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Abbott, Sylmar, California
Conditions: Cardiac Pacemaker, Arrythmia, Bradycardia
Register for Updates
Intervention for Virologic Suppression in Youth
NCT05877729
Recruiting
The goal of this randomized clinical trial is to test the effect of a technology-based intervention with an Adaptive Treatment Strategy (ATS) among youth living with HIV (YLWH) (18-29 years old). This piloted and protocolized intervention combines: (1) brief weekly sessions with a counselor via a video-chat platform (video-counseling) to discuss mental health (MH), substance use (SU), HIV care engagement, and other barriers to care; and (2) a mobile health application (app) to address barriers s... Read More
Gender:
ALL
Ages:
Between 18 years and 29 years
Trial Updated:
04/02/2025
Locations: Division of Prevention Science, Center for AIDS Prevention Studies (CAPS), San Francisco, California
Conditions: HIV/AIDS, Young Adult, Mobile Health, Mental Health Issue, Substance Use
Register for Updates
Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors
NCT05651022
Recruiting
INDP-D101 is a Phase 1/2, open-label, multi-center, dose escalation and expansion study evaluating the safety, tolerability and clinical activity of Decoy20 as monotherapy and in combination with tislelizumab in patients with locally advanced or metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: University of Southern California- Norris Cancer Center, Los Angeles, California
Conditions: Solid Tumor, Adult, HCC - Hepatocellular Carcinoma, CRC (colorectal Cancer), Pancreatic Adenocarcinoma, NSCLC Non-small Cell Lung Cancer, Squamous Cell Cancer of the Head and Neck, UC (Urothelial Cancer), MSI-H Cancer
Register for Updates