California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-2-307-ADC in patients with advanced cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Providence St. Jude Medical Center, Fullerton, California
Conditions: Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
Pilot Test of Apnea and Insomnia Relief for Veterans With Gulf War Illness
Recruiting
The purpose of this study is to determine whether a behavioral sleep treatment improves sleep and other Gulf War Illness (GWI) symptoms in Gulf War Veterans with GWI.
Gender:
ALL
Ages:
Between 48 years and 80 years
Trial Updated:
04/02/2025
Locations: VA Health Care System, San Francisco, California
Conditions: Gulf War Illness
International Registry of Patients With Alpha Thalassemia
Recruiting
This is an international prospective registry of patients with Alpha thalassemia to understand the natural history of the disease and the outcomes of fetal therapies, with the overall goal of improving the prenatal management of patients with Alpha thalassemia.
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Alpha-Thalassemia, Alpha Thalassemia Major, Alpha Thalassemia Minor
Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab
Recruiting
The objective of this clinical trial is to develop a cell therapy for Fanconi Anemia which enables enhanced donor hematopoietic and immune reconstitution with decreased toxicity by transplanting depleted stem cells from a donor after using an experimental antibody treatment called JSP-191 as a part of conditioning. This experimental treatment will hopefully cause fewer side effects than chemotherapy (the current standard of care method). Participants will be administered the conditioning regime... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
04/02/2025
Locations: Stanford University, Stanford, California
Conditions: Fanconi Anemia
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)
Recruiting
Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target for cholesterol lowering in the general population and recent studies among individuals without HIV have shown that PCSK9 inhib... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections
Collection of Blood for Multiple Collaborative Studies
Recruiting
This study seeks to confidentially collect blood from HIV-positive individuals and HIV-negative controls to provide basic scientists with specimens for collaborative studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
The Use of Leukapheresis to Support HIV Pathogenesis Studies
Recruiting
Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges. Also, there is emerging consensus that persistent HIV-associated disease occurs during long-term highly active antiretroviral therapy (HAART). This disease may be due to either direct drug-toxicity and/or persistent viral replication/production and/or persistent HIV-associated inflammation... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma
Recruiting
A phase 2 multicenter study of VI-0609 vs BiCNU in the BEAM high-intensity conditioning regimen for AHCT in subjects with lymphomas.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Lymphoma Undergoing Autologous Hematopoietic Cell Transplantation
WATER IV Prostate Cancer
Recruiting
This is a multicenter, prospective, randomized clinical trial that aims to assess the safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to high-risk localized prostate cancer who are candidates for, or have opted for, prostatectomy. Participants will be randomized to either Aquablation Therapy or radical prostatectomy and followed up to 10 years.
Gender:
MALE
Ages:
45 years and above
Trial Updated:
04/01/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Localized Prostate Cancer
Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV
Recruiting
The goal of this clinical trial is to learn whether it is possible to use intramuscular (IM) ketamine in combination with psychotherapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in publicly insured patients with or at-risk for HIV disease. The main questions it aims to answer are: * Do publicly insured patients find ketamine-assisted psychotherapy feasible and acceptable as a potential treatment for MeUD? * Is IM ketamine safe and tolerable among patients with MeUD? Parti... Read More
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
04/01/2025
Locations: San Francisco Department of Public Health, San Francicso, California
Conditions: Methamphetamine Use Disorder
Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer
Recruiting
This phase Ib/II trial studies the side effects, best dose, and effectiveness of enfortumab vedotin (EV) in combination with pembrolizumab and radiation therapy for treating patients with muscle invasive bladder cancer. Standard of care treatment for muscle invasive bladder cancer is chemotherapy, to shrink the tumor before the main treatment is given (neoadjuvant), followed by surgery to remove all of the bladder as well as nearby tissues and organs (radical cystectomy). In cases where patients... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Bladder Cancer, Muscle-Invasive Bladder Carcinoma, Stage II Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8
Promoting Physical Activity in Older Hispanic/Latino(a) Adults
Recruiting
In this randomized controlled trial, study staff will randomize 130 Hispanic/Latino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted De Pie physical activity intervention or an active comparison program focusing on general brain health topics. The purpose of this study is to determine if 12 weeks of the culturally adapted and fully remote De Pie y a Movernos intervention improves self-efficacy, habit s... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
04/01/2025
Locations: University of California San Diego, San Diego, California
Conditions: Sedentary Behavior, Physical Inactivity, Alzheimer Disease, Protection Against