California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease
NCT05524571
Recruiting
To evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Site Number -1520, Pasadena, California
Conditions: Thyroid Eye Disease
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Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
NCT05488431
Recruiting
This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). This trial will be enrolled at UCSF and UCLA. Collaborators at Massachusett... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections, Atherosclerosis
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EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA
NCT05480228
Recruiting
The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 13 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Painful Diabetic Neuropathy
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Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
NCT05361070
Recruiting
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal epilepsy among children with acute provoked neonatal seizures. The researchers aim to develop prediction rules to stratify neonates into low, medium, and high risk for post-neonatal epilepsy based on clinical, electroencephalogram (EEG), magnetic resonance... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhage, Epilepsy, Gene Abnormality
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First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer
NCT05156866
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-2-307-ADC in patients with advanced cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Providence St. Jude Medical Center, Fullerton, California
Conditions: Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
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Pilot Test of Apnea and Insomnia Relief for Veterans With Gulf War Illness
NCT05137743
Recruiting
The purpose of this study is to determine whether a behavioral sleep treatment improves sleep and other Gulf War Illness (GWI) symptoms in Gulf War Veterans with GWI.
Gender:
ALL
Ages:
Between 48 years and 80 years
Trial Updated:
04/02/2025
Locations: VA Health Care System, San Francisco, California
Conditions: Gulf War Illness
Register for Updates
International Registry of Patients With Alpha Thalassemia
NCT04872179
Recruiting
This is an international prospective registry of patients with Alpha thalassemia to understand the natural history of the disease and the outcomes of fetal therapies, with the overall goal of improving the prenatal management of patients with Alpha thalassemia.
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Alpha-Thalassemia, Alpha Thalassemia Major, Alpha Thalassemia Minor
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Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab
NCT04784052
Recruiting
The objective of this clinical trial is to develop a cell therapy for Fanconi Anemia which enables enhanced donor hematopoietic and immune reconstitution with decreased toxicity by transplanting depleted stem cells from a donor after using an experimental antibody treatment called JSP-191 as a part of conditioning. This experimental treatment will hopefully cause fewer side effects than chemotherapy (the current standard of care method). Participants will be administered the conditioning regime... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
04/02/2025
Locations: Stanford University, Stanford, California
Conditions: Fanconi Anemia
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Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)
NCT03207945
Recruiting
Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target for cholesterol lowering in the general population and recent studies among individuals without HIV have shown that PCSK9 inhib... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections
Register for Updates
Collection of Blood for Multiple Collaborative Studies
NCT01336855
Recruiting
This study seeks to confidentially collect blood from HIV-positive individuals and HIV-negative controls to provide basic scientists with specimens for collaborative studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
Register for Updates
The Use of Leukapheresis to Support HIV Pathogenesis Studies
NCT01161199
Recruiting
Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges. Also, there is emerging consensus that persistent HIV-associated disease occurs during long-term highly active antiretroviral therapy (HAART). This disease may be due to either direct drug-toxicity and/or persistent viral replication/production and/or persistent HIV-associated inflammation... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
Register for Updates
A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma
NCT06915246
Recruiting
A phase 2 multicenter study of VI-0609 vs BiCNU in the BEAM high-intensity conditioning regimen for AHCT in subjects with lymphomas.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Lymphoma Undergoing Autologous Hematopoietic Cell Transplantation
Register for Updates