California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mindful Motivation for Reducing Binge Eating
Recruiting
The aim of this study is to test how acceptable and feasible a new eating intervention is in people with overweight and binge eating. This intervention combines mindful eating with motivational interviewing to target binge eating. The main questions this clinical trial aims to answer are: How well do participants accept the new intervention (acceptability)? Is the intervention practical and easy to implement (feasibility)? In this trial researchers will compare the new eating intervention (mot... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Binge Eating, Psychological, Health Behavior, Weight, Body
Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension
Recruiting
HQ-HTN-G01 is a prospective, multicenter, single arm, open label, early feasibility study to evaluate initial safety and device design concept of "HyperQureTM RDN System", laparoscopic renal denervation therapy, in patients with resistant hypertension on three(3) or more antihypertensive medications
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
03/25/2025
Locations: University of California Irvine, Orange, California
Conditions: Resistant Hypertension
Feasibility and Preliminary Effects of Fasting-Mimicking Diet in Asian Americans with Prediabetes
Recruiting
This is a pilot study to determine the feasibility of studying the Fasting-Mimicking Diet (FMD), a dietary approach that involves the consumption of a specifically formulated, calorie-restricted nutrition regimen with a customized macronutrient composition, ratio, and quantity over a 5- day period, on a larger scale in Asian Americans with prediabetes and to examine the preliminary effects of the diet in study participants. The main questions the study aims to answer are: 1. What are the recru... Read More
Gender:
ALL
Ages:
Between 30 years and 65 years
Trial Updated:
03/25/2025
Locations: UC Irvine, Irvine, California
Conditions: Prediabetes, Prediabetic State
An INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY to ASSESS the PERFORMANCE of the CORDIO HEARO SYSTEM
Recruiting
Study Design: This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of the HearO system.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/25/2025
Locations: UC San Diego Health, La Jolla, California
Conditions: Heart Failure
SENTI-202: Off-the-shelf Logic Gated CAR NK Cell Therapy in Adults with CD33 And/or FLT3 Blood Cancers Including AML/MDS
Recruiting
This is an open-label study of the safety, biodynamics, and anti-cancer activity of SENTI-202 (an off-the-shelf logic gated CAR NK cell therapy) in patients with CD33 and/or FLT3 expressing blood cancers, including AML and MDS.
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
03/25/2025
Locations: UCLA Medical Center, Los Angeles, California
Conditions: AML/MDS, CD33 Expressing Hematological Malignancies, FLT3 Expressing Hematological Malignancies
Evaluating Process of Change in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for Depression
Recruiting
This study will compare two psychological treatments for major depressive disorder (MDD): cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both treatments are well-studied and supported by evidence as effective options for people experiencing depression. These treatments will be delivered in an online group format via Zoom. The study will enroll up to 100 participants with depression. Half of the participants will receive online group CBT and half will receive onl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Depression
Precision Dosing of Metformin in Youth With T2D
Recruiting
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
Gender:
ALL
Ages:
Between 10 years and 21 years
Trial Updated:
03/25/2025
Locations: UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic, Oakland, California
Conditions: Type 2 Diabetes
InfasurfAero™ Versus Sham Treatment in Preterm Newborns with RDS
Recruiting
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated way and without the need for a breathing tube or interrupting nasal respiratory support.
Gender:
ALL
Ages:
Between 29 weeks and 36 weeks
Trial Updated:
03/25/2025
Locations: Sharp Mary Birch Hospital for Women & Newborns, San Diego, California
Conditions: Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
Natural History Study of Patients with HPDL Mutations
Recruiting
This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations
Gender:
ALL
Ages:
All
Trial Updated:
03/25/2025
Locations: Eun Hae Lee, San Diego, California
Conditions: Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia, Spastic Paraplegia, White Matter Disease, Neonatal Encephalopathy, Mutation, Genetic Disease
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
Recruiting
This is a single center, prospective, double-blinded randomized controlled trial comparing the efficacy of bilateral superficial cervical plexus blocks (BSCPB) with local wound infiltration vs placebo with local wound infiltration in reducing thyroid surgery postoperative pain. Primary outcomes assessed are post operative pain, quality of life/recovery, post operative nausea/vomiting and opioid use.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/25/2025
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Post Operative Pain, Nausea and Vomiting, Postoperative, Opioid Use
Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults
Recruiting
Assess the impact of a remote, app-delivered digital meditation intervention on emotional well-being of lonely older adults. Neuroimaging, electrophysiological (EEG), and autonomic physiology will be used to assess the neural correlates of the intervention. EEG and autonomic physiology will be collected while participants watch 30 min of an awe-inspiring movie. fMRI and autonomic physiology will be collected in the context of a social exploration/exploitation task.
Gender:
ALL
Ages:
Between 60 years and 120 years
Trial Updated:
03/25/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Loneliness, Older Adults, fMRI, Emotions, EEG, Digital Intervention, Meditation
Study of Edecesertib in Participants With Cutaneous Lupus Erythematosus (CLE)
Recruiting
The goal of this clinical study is to test how edecesertib (formerly known as GS-5718) can be useful in treating Cutaneous Lupus Erythematosus (CLE) in participants with CLE. Information on what is happening in the body relating to CLE, how the body processes, is affected by and responds to the study drug, and any study drug side effects will also be collected in this study.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/25/2025
Locations: Center for Dermatology Clinical Research Inc., Fremont, California
Conditions: Cutaneous Lupus Erythematosus (CLE)