California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis.
Recruiting
Primary objective: To evaluate the efficacy of hymecromone plus standard of care compared with standard of care alone in the treatment of adolescents and adults with primary sclerosing cholangitis (PSC). Secondary objectives: To evaluate the change in Alkaline Phosphatase (ALP) from baseline to 6 months post-treatment following treatment with hymecromone plus standard of care compared with standard of care. To evaluate changes in biomarkers of PSC disease during hymecromone treatment, namely:... Read More
Gender:
ALL
Ages:
Between 14 years and 75 years
Trial Updated:
11/24/2024
Locations: Stanford Clinic, Redwood City, California
Conditions: Primary Sclerosing Cholangitis
Use of CereGate Therapy for Freezing of Gait in PD
Recruiting
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
11/24/2024
Locations: Cedars Sinai Neurology, Los Angeles, California
Conditions: Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
Recruiting
A pilot pharmacokinetic trial to determine the safety and efficacy of a flavored, orally administered irinotecan VAL-413 (Orotecan®) given with temozolomide for treatment of recurrent pediatric solid tumors including but not limited to neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, hepatoblastoma and medulloblastoma
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
11/24/2024
Locations: UCSF, Mission Bay - Benioff Children's Hospital, San Francisco, California
Conditions: Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Hepatoblastoma, Medulloblastoma
Long-term Result of DTPA (Diethylenetriamine Pentaacetate) Chelation for Gadolinium Deposition Disease
Recruiting
This study is aimed at describing the degree of benefit, if any, and the adverse effects, if any, from receiving 5 or more treatment sessions of Gadolinium Deposition Disease using two-day chelation treatment with the chelating agents Calcium Diethylenetriamine pentaacetate (Ca-DTPA) and Zinc Diethylenetriamine pentaacetate (Zn-DTPA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/23/2024
Locations: Stanford University Medical Center, Stanford, California
Conditions: Gadolinium Deposition Disease, Ca-DTPA
Quantitative Ultrasound to Assess Steatotic Liver Disease in Children
Recruiting
This research study is being conducted to find out more about advanced ultrasound techniques to non-invasively evaluate liver disease in children. The investigators are developing advanced techniques for analyzing ultrasound data and images of the liver, and they will compare it to other established methods used to evaluate the liver, including liver MRI. The investigators plan to develop and test the advanced analysis techniques using conventional full-size ultrasound machines and, if possible... Read More
Gender:
ALL
Ages:
Between 9 years and 18 years
Trial Updated:
11/22/2024
Locations: University of California San Diego, La Jolla, California
Conditions: MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
Recruiting
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue reactivity.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Smoking Cessation, Tobacco Use Disorder
Healthy Lifestyles in Bipolar Disorder: Bay Area Study
Recruiting
The goal of this clinical trial is to understand how level of adherence with time-restricted eating (TRE) predicts change in diurnal rhythms (as measured using the amplitude of diurnal peripheral clock gene expression), and how those changes predict lower mania and depressive symptoms, and downstream improvements in quality of life. The effects of diurnal amplitude of clock gene expression is expected to remain significant when controlling for change in glucose tolerance and inflammation. Partic... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California Berkeley, Berkeley, California
Conditions: Bipolar Disorder, Time Restricted Eating
Neurobehavioral Affective Control Training
Recruiting
The goal of this clinical trial is to test a new cognitive training program to improve emotion regulation in adults. The investigators' primary aim is to determine whether participating in this program addresses two key features of emotion dysregulation associated with psychiatric disorders: (1) emotion-related impulsivity and (2) rumination. The investigators will further evaluate participants' perceived acceptability and feasibility of treatment procedures. Secondarily, the investigators will... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California, Berkeley, California
Conditions: Emotional Distress, Impulsive Behavior, Mood Lability, Mood Instability, Rumination, Psychopathology, Affective Symptoms
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer
Recruiting
This is a Phase III, randomised, open-label, 3-arm, multicentre, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with investigator's choice chemotherapy in combination with pembrolizumab in participants with PD-L1 positive locally recurrent inoperable or metastatic TNBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Research Site, Duarte, California
Conditions: Breast Cancer
To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL
Recruiting
Part 1: This is a 5 Arm study primarily to determine the best dose out of the two dose levels of Belinostat and Pralatrexate combined with CHOP/COP in newly diagnosed PTCL patients based on Safety for part 2 study. Part 2 (Efficacy and Safety): This is a 3 Arm study. Patients with previously untreated PTCL will be randomized 1:1:1 into 1 of 3 treatment groups: 2 experimental treatment groups (Bel-CHOP or Fol-COP) or 1 active comparator treatment group (CHOP). Patients will be treated for up to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: University of California, San Francisco Fresno, Clovis, California
Conditions: Peripheral T Cell Lymphoma
Food FARMacia: Reducing Childhood Obesity in Households With Food Insecurity
Recruiting
The goal of this clinical trial is to test whether the Food FARMacia intervention to reduce food insecurity is feasible and accepted among families with an infant age 6 to less than 18 months receiving pediatric primary care. All participants will receive nutrition education and anticipatory guidance to support healthy meal preparation in addition to usual care.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
11/22/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Nutrition, Healthy
Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)
Recruiting
The purpose of this Phase 2, open-label, sequential dose cohort study is to evaluate the safety, efficacy, and pharmacokinetics (PK) of CRN04894 in participants with classic congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency.
Gender:
ALL
Ages:
Between 16 years and 75 years
Trial Updated:
11/22/2024
Locations: Crinetics Study Site, Pasadena, California
Conditions: Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia