California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products
NCT06783621
Recruiting
A study to evaluate overall participant satisfaction of face and neck appearance after treatment with onabotulinumtoxinA, JUVÉDERM® products, KYBELLA, CoolSculpting Elite, and select SkinMedica products in a diverse population.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
03/13/2025
Locations: Marcus Facial Plastic Surgery /ID# 270408, Redondo Beach, California
Conditions: Facial Contouring
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Skin Barrier Function and Inflammation in Aging: The BIA Study
NCT06750653
Recruiting
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which m... Read More
Gender:
ALL
Ages:
70 years and above
Trial Updated:
03/13/2025
Locations: UCSF, San Francisco, California
Conditions: Inflammation, Skin Inflammation, Aging
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Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet
NCT06574178
Recruiting
Psoriasis is a chronic inflammatory disease that affects the skin and joints in 2-3 % of people in the United States. This inflammation of the skin, joints, and blood vessels in patients with psoriasis has been measured by older PET Scan technology but with limitations. With the new EXPLORER PET scanner technology, the investigators are testing to see if the EXPLORER is better than previous PET scanners and improve our ability to assess inflammation in patients. Also, it is known that the typic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: University of California, Davis - Dermatology Department, Sacramento, California
Conditions: Psoriasis
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PRescription Exercise for Older Men With Urinary Disease
NCT06225479
Recruiting
This is a single-center pilot randomized controlled trial among 68 physically "inactive" older men with lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (LUTS/BPH) assessing a 12-week remote exercise intervention versus health education control.
Gender:
MALE
Ages:
60 years and above
Trial Updated:
03/13/2025
Locations: San Francisco VA Medical Center, San Francisco, California
Conditions: Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
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Study of DF6215 in Patients with Advanced Solid Tumors
NCT06108479
Recruiting
A Phase I/Ib, First-In-Human, Multi-Part, Open-Label Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of DF6215 Monotherapy and in Combination Therapy in Patients with Advanced (Unresectable, Recurrent, or Metastatic) Solid Tumors; is designed to assess the safety, tolerability, and preliminary efficacy of DF6215 alone or in combination with pembrolizumab in patients with advanced solid tumors. The study is open-label, meaning both participants an... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles, California
Conditions: Solid Tumor, Adult, Solid Tumor Cancer
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Flashed Light Therapy for Adolescents with ADHD and Delayed Sleep Timing
NCT06036420
Recruiting
The primary aim of the present research project is to examine the feasibility, as measured by treatment perceptions, and tolerability, as measured by adherence and attrition, of two weeks of flashed light therapy alone followed by four weeks of daily flashed light therapy combined with four weekly videoconference-delivered cognitive behavioral therapy sessions targeting circadian rhythms and sleep in four adolescents aged 14 to 17 years with attention-deficit/hyperactivity disorder and delayed s... Read More
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
03/13/2025
Locations: Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California
Conditions: ADHD
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To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
NCT05908084
Recruiting
The goal of this clinical trial is to compare the number of catheter-free days (CFD) and the rate and severity of any dialysis access-related infections between the ATEV and AVF groups over 12 months in patients with end-stage renal disease (ESRD) needing hemodialysis (HD). Participants will be stratified by location of the vascular access (forearm versus upper arm) and by type of AVF creation procedure planned by the surgeon at randomization (1-stage AVF versus 2-stage AVF). The comparator is... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: El Centro Regional Medical Center, El Centro, California
Conditions: End Stage Renal Disease (ESRD)
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A Phase I/II Study of VLS-1488 in Subjects with Advanced Cancer
NCT05902988
Recruiting
This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary, Squamous Non-small-cell Lung Cancer, Triple Negative Breast Cancer, Gastric Adenocarcinoma, Colorectal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Esophageal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Transitional Cell Carcinoma of Bladder, Head and Neck Squamous Cell Carcinoma, Ovarian Carcinosarcoma, Uterine Carcinosarcoma, Uterine Serous Carcinoma, Endometrium Cancer, Chromosomal Instability
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Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
NCT05880797
Recruiting
The purpose of this study is to better understand the natural history of oropharyngeal carcinoma (OPC), with or without an association with the human papilloma virus (HPV). For this study, the investigators plan to collect blood from OPC patients prior to treatment and at six subsequent time points.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Stanford University, Palo Alto, California
Conditions: Oropharyngeal Carcinoma, Human Papilloma Virus
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SEEG-Guided DBS for OCD
NCT05623306
Recruiting
This is a multi-site, double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of DBS surgery and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment.
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/13/2025
Locations: Stanford University, Stanford, California
Conditions: Obsessive-Compulsive Disorder
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Forehead Temperature-Regulating Therapy for Insomnia in Adults with Tourette's Disorder
NCT05499741
Recruiting
The primary aim of the present research project is to investigate the preliminary effects of four weeks of forehead temperature-regulating therapy on insomnia in adults with Tourette's disorder and co-occurring insomnia disorder. This project will also examine the effects of the device on depression, anxiety, and daytime sleepiness, and explore its effects on tic severity.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/13/2025
Locations: Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California
Conditions: Tourette's Disorder, Insomnia
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PET Imaging Study of 89Zr-DFO-YS5 in Men with Prostate Cancer
NCT05245006
Recruiting
CD46 is an exciting new therapeutic target in prostate cancer, with the antibody drug conjugate FOR46 under investigation in phase I clinical trials. The hypothesis of the study is that CD46 expression, measured via our novel imaging biomarker, is a characteristic feature of mCRPC, and particularly common in the most lethal forms of the disease including adenocarcinoma and Small-cell neuroendocrine carcinoma (SCNC). These data will provide crucial information about the feasibility of targeting c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Prostate Cancer, Metastatic Castration-resistant Prostate Cancer
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