California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A PIVOTAL STUDY EVALUATING SAFETY and EFFICACY of the SHIRATRONICS MIGRAINE THERAPY SYSTEM
Recruiting
Prospective, multi-center, double blind, randomized, sham-controlled study to evaluate neuromodulation in patient with chronic migraine. The study hypothesis to be tested is the mean reduction in mean monthly headache days between patients in treatment versus sham.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/04/2025
Locations: UC San Diego Health, La Jolla, California
Conditions: Headache Migraine Chronic
Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss
Recruiting
The purpose of this industry-initiated research study is to test that a powered microprocessor controlled knee improves metabolic function during walking in level and sloped conditions as compared to the subject's physician prescribed prosthesis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/04/2025
Locations: Loma Linda University, Loma Linda, California
Conditions: Transfemoral Amputation
Trial of Vision Therapy for Intermittent Exotropia
Recruiting
The main objective of this randomized trial comparing vision therapy to observation is to determine the short-term effectiveness of vision therapy on distance intermittent exotropia control. The results will help determine whether to proceed to a full-scale, long-term randomized trial.
Gender:
ALL
Ages:
Between 8 years and 16 years
Trial Updated:
03/04/2025
Locations: Southern California College of Optometry at Marshall B. Ketchum University, Fullerton, California
Conditions: Intermittent Exotropia
Responsive Neurostimulation For Loss Of Control Eating
Recruiting
The primary objective of this trial is to assess device function and safety, with secondary objectives including the feasibility.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/04/2025
Locations: Stanford University, Stanford, California
Conditions: Loss of Control Eating, Obesity, Morbid
Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma
Recruiting
The purpose of this study is to determine if giving an experimental drug called venetoclax in combination with lenalidomide and rituximab is safe and effective for treating people with Mantle Cell Lymphoma (MCL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: City of Hope Medical center, Duarte, California
Conditions: Mantle Cell Lymphoma
FebriDx® Method Comparison Study Protocol
Recruiting
The goal of this observational study is to learn about the performance and ease of use of FebriDx when operated by persons without laboratory experience or training in patients with acute respiratory symptoms. The main question it aims to answer is: • Is FebriDx accurate at differentiating bacterial from non-bacterial respiratory infections when used by untrained operators? Trained and untrained participants will run the FebriDx test on patients with respiratory symptoms to evaluate comparabili... Read More
Gender:
ALL
Ages:
Between 12 years and 64 years
Trial Updated:
03/03/2025
Locations: Ascada Health, Fullerton, California
Conditions: Acute Respiratory Infections (ARIs)
Babies' Brain Responses to Strangers
Recruiting
Researchers at the Diversity in Development Lab at UC Santa Cruz are investigating how babies' brain activities respond to people from familiar and unfamiliar racial backgrounds.
Gender:
ALL
Ages:
Between 7 months and 12 months
Trial Updated:
03/03/2025
Locations: Social Science 2 Building, Santa Cruz, California
Conditions: Infant Development
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial
Recruiting
This phase III trial compares proton craniospinal irradiation (pCSI) to involved-field radiation therapy (IFRT) for the treatment of breast or non-small cell lung cancer that has spread from where it first started to the cerebrospinal fluid filled space that surrounds the brain and spinal cord (leptomeningeal metastasis). Patients with leptomeningeal metastasis (LM) may develop multiple areas of nervous system (neurologic) impairment that can be life-threatening. Radiation therapy (RT) effective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: UC San Diego Health System - Encinitas, Encinitas, California
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Leptomeninges, Stage IV Lung Cancer AJCC v8
Bladder Preservation for Patients with Muscle Invasive Bladder Cancer (MIBC) with Variant Histology
Recruiting
This is a Phase II, single cohort study designed to evaluate outcomes in patients with muscle invasive bladder cancer (MIBC) with variant histology who receive neoadjuvant chemotherapy (NAC) with or without immunotherapy (IO) followed by trimodal therapy (TMT). Enrolled patients will undergo at least 3 cycles of NAC +/- IO (oncologist's choice) followed by a four- or six-week course of concurrent standard of care chemotherapy and radiation therapy. These patients will be compared with historical... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Muscle-Invasive Bladder Carcinoma, Tumor
Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors
Recruiting
This is a Phase I open label, dose-escalation study of intravenous (IV) infusion of ONC-841 as a single agent in patients with advanced/metastatic solid tumors. The study will evaluate seven dose levels of ONC-841 starting from 0.03 mg/kg to 30 mg/kg.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: University of California at Davis Cancer Center, Sacramento, California
Conditions: Advanced Solid Tumor
Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)
Recruiting
This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Endo Site 49, Castro Valley, California
Conditions: Plantar Fibromatosis, Ledderhose Disease
Safety Study for a Gamma Delta T Cell Product Used with Low Dose Radiotherapy in Patients with Locally Advanced or Metastatic NSCLC or Solid Tumors with Bone Metastases
Recruiting
This is a clinical trial studying intravenous infusions of allogeneic gamma delta T cells after receiving low dose radiotherapy in participants with locally advanced or metastatic non-small cell lung cancer or solid tumors with bone metastases to evaluate the safety and efficacy of combining immunotherapy with radiation therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Beverly Hills Cancer Center, Beverly Hills, California
Conditions: Carcinoma, Non-Small-Cell Lung Cancer, Bone Metastases from Solid Tumors