California Paid Clinical Trials

A listing of 5617 clinical trials in California actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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DBT Skills Groups for Veterans at High Risk for Suicide Attempt

NCT05000749

Recruiting

Veteran suicide death is a national crisis. Risk factors include emotion dysregulation, which occurs across mental health disorders. Dialectical behavior therapy (DBT) is an evidence-based suicide intervention that targets emotion dysregulation but is resource-intensive and not widely available at VHA. A more efficient evidence-based DBT Skills Group (DBT-SG) is associated with reduced suicidal ideation and emotion dysregulation and likely more feasible to implement at VHA. This is a randomized... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/13/2025

Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California

Conditions: Suicide, Attempted

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Cefixime Clinical Trial

NCT04958122

Recruiting

This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/13/2025

Locations: University of Southern California, Los Angeles, California

Conditions: Syphilis, Human Immunodeficiency Virus

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Allograft Dysfunction in Heart Transplant

NCT03102125

Recruiting

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/13/2025

Locations: UC San Diego, La Jolla, California

Conditions: Heart Transplant Failure and Rejection

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A Phase 2 Study of MZE829 in Adults with APOL1 Kidney Disease

NCT06830629

Recruiting

This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

02/12/2025

Locations: Amicis Research Center, Fairfield, California

Conditions: Proteinuric Kidney Disease

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At-Home Cardiac Rehabilitation for Adolescents At Risk for Heart Failure

NCT06826534

Recruiting

The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer are * To evaluate the efficacy of an at-home CORE model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors. * To evaluate the exercise adherence rate among adolescents at risk for heart failure and assess... Read More

Gender:

ALL

Ages:

Between 0 years and 21 years

Trial Updated:

02/12/2025

Locations: Children's Hospital Los Angeles, Los Angeles, California

Conditions: Cardiovascular Complication, Chemotherapeutic Toxicity

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Bone Mineral Density Agreement Study Between EOSedge™ Versus Traditional DXA

NCT06659055

Recruiting

The purpose of this research is to collect medical imaging data to allow for the comparison of bone mineral density measurements from two different types of low-dose x-ray exams, EOSedge and conventional DXA. The main question it aims to answer is: Is there agreement between the calculated T-scores between the 2 different types of x-ray exams?

Gender:

ALL

Ages:

20 years and above

Trial Updated:

02/12/2025

Locations: ATEC Carlsbad, Carlsbad, California

Conditions: Healthy, Indicated for EOSedge Imaging

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Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects with Myasthenia Gravis

NCT06106672

Recruiting

Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-106.

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

02/12/2025

Locations: Infusion for Health, Brea, California

Conditions: Myasthenia Gravis, Generalized Myasthenia, AChR Myasthenia Gravis, MuSK MG

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Endotype-Targeted Therapy to Rescue OSA Patients Struggling with CPAP Adherence (TOP-CPAP)

NCT05951023

Recruiting

More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA. However, most patients use CPAP only for part of the night (4-5hours) and about 50% patients discontinue CPAP long-term. Alternative therapies are limited, thus many OSA patients remain at risk of OSA sequelae (e.g. sleepiness, memory issues, high blood pressure, etc.). Importantly, different patients get OSA for differ... Read More

Gender:

ALL

Ages:

Between 21 years and 65 years

Trial Updated:

02/12/2025

Locations: UC San Diego; Altman Clinical and Translational Research Institute Building, La Jolla, California

Conditions: Obstructive Sleep Apnea

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Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy

NCT05949593

Recruiting

This Phase 3, multicenter, double-masked, parallel-group, placebo-controlled, randomized, fixed-dose clinical study is designed to evaluate the efficacy and safety of tinlarebant (LBS-008) in subjects diagnosed with GA.

Gender:

ALL

Ages:

Between 60 years and 85 years

Trial Updated:

02/12/2025

Locations: Belite Study Site, Arcadia, California

Conditions: Geographic Atrophy

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Tobacco Cessation Care for Cancer Patients by Automated Interactive Outreach

NCT05829824

Recruiting

This is a multi-arm, randomized controlled, pilot study which will recruit cancer patients who have been seen by a UCSF Cancer Center-affiliated clinical department to evaluate the efficacy of "CareConnect". This is the first study to assess the efficacy CareConnect, a combination of the Ask-Advise-Connect (AAC) with an Interactive Voice Response (IVR) delivering cancer-targeted educational messages to support referral to smoking cessation resources for patients with cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/12/2025

Locations: University of California, San Francisco, San Francisco, California

Conditions: Cancer, Tobacco Dependence, Tobacco Use Cessation

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Fecobionics in Biofeedback Therapy in Dyssynergia Patients

NCT05807321

Recruiting

Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients. The investigators have developed a novel device named Fecobionics that provide detailed mapping of physiological parameters during defecation. The aim of the study is to use Fecobionics to assess anorectal function in dyssynergia patients and monitor and predict the outcome of the biofeedback thera... Read More

Gender:

ALL

Ages:

Between 21 years and 75 years

Trial Updated:

02/12/2025

Locations: California Medical Innovations Institute, San Diego, California

Conditions: Dyssynergia, Constipation

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Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health

NCT05616260

Recruiting

Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems. For example, patients with OSA often feel very sleepy and are at risk of falling asleep while driving. OSA also causes elevated blood pressure increasing the risk for heart attacks and strokes. Patients with OSA are often treated with a face-mask that helps them breath at night but can be difficult to tolerate. In fact, about half the patients eventually stop using this mask. Because there are few other treatments (and no drug therapy), many OSA patients are still untreated. Of note, especially young adults (i.e. 18 to 50 years old) benefit from treating their OSA, but they are also less likely to use the mask. Acetazolamide (a mild diuretic drug) has been used for over 50 years to treat many different conditions and is well tolerated. Recent data suggest, that acetazolamide may help OSA patients to not choke in their sleep and lower their blood pressure. Especially young adults with OSA are likely to respond well to this drug. Further, its low cost (66¢/day) and once- daily dosing may be particularly attractive for young OSA patients unable or unwilling to wear a mask each night. But previous studies had many limitations and did not focus on young adults. The goal of this study is to test if acetazolamide can improve sleep apnea and cardiovascular health in young adults with OSA (18-50 years old), and how it does that. Thus, we will treat 46 young OSA patients with acetazolamide or placebo for 2 weeks each. The order in which participants receive the drug or placebo will be randomized. At the end of each 2 week period we will assess OSA severity and cardiovascular health. Thus, this study will help assess acetazolamide's potential value for OSA treatment, and may also help to identify patients who are most likely to respond to acetazolamide (including select individuals \>50 years of age). Ultimately, this work promises a drug therapy option for millions of OSA patients who are unable to tolerate current treatments. Read Less

Gender:

ALL

Ages:

Between 18 years and 50 years

Trial Updated:

02/12/2025

Locations: UC San Diego; Altman Clinical and Translational Research Institute Building, La Jolla, California

Conditions: Obstructive Sleep Apnea

Learn More ›

Kaiser Permanente houses over 6,000 physicians in southern California and it is also one of the largest research centers on the state. On its clinical trial division, Kaiser Permanente conducts clinical trials of almost every specialty funded by pharmaceutical companies, government, and foundations.

The Cedars-Sinai Medical Center located in Los Angeles is one of the largest research centers owned and operated by a private hospital in the United States. Focusing on biomedical, cancer, and heart research among other specialties, you can find almost any type of clinical trials for both health and non-healthy volunteers at the research division of Cedar-Sinai Medical Center.

There are around 100,000 clinical trials happening every year across the United States about almost every condition out there. While most clinical trials are testing drugs or medical devices there are also many behavioral and observational trials going on at any point in time. Many paid research studies are held at these California locations.

Clinical trials are incredibly important for making new medical and scientific discoveries, finding new and better methods for diagnosing medical conditions early, testing new interventions, and even developing safer and more effective surgical procedures.

In order for all these discoveries to me made available to the general population they need to go through years of rigorous testing both in healthy and non-healthy volunteers. During those years, medical professionals follow a protocol that has been previously approved by the FDA or other regulatory agency to test the effectiveness and safety of their discovery.

Other people choose to participate in a clinical trial because they feel it is a good way to contribute to the advancement of medical knowledge and that their participation can help many people in the future. The following lists of trials are broken down by condition, and to find a specific clinical trial in your area click through to clinicaltrials.gov.