California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
SPECT/CT for the Characterization of Renal Masses
NCT03996850
Recruiting
This trial studies how well technetium Tc-99m sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) works on clinical decision making in patients with kidney tumors. Diagnostic procedures, such as technetium Tc-99m sestamibi SPECT/CT may be a less invasive way to check for kidney tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Kidney Neoplasm, Renal Mass
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Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma
NCT03886311
Recruiting
This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Sarcoma
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SAINT:Trabectedin, Ipilimumab and Nivolumab for Previously Treated Advanced Soft Tissue Sarcoma
NCT03138161
Recruiting
This is an open label, dose-seeking phase 1/2 study using escalating doses of TRABECTEDIN given intravenously with defined doses of IPILIMUMAB and NIVOLUMAB based on preliminary results of the Checkmate 012 trial for NSCLC (Hellman et al., 2016). For the Phase 1 Part of Study, only previously treated patients will be enrolled. For the Phase 2 Part of Study, previously treated patients will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: Sarcoma Oncology Research Center, Santa Monica, California
Conditions: Advanced Soft Tissue Sarcoma, Metastatic Soft Tissue Sarcoma
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Therapeutic Effects of Electrical Vestibular Stimulation (EVS) on Balance and Gait
NCT06846047
Recruiting
The aim of the study to is determine the safety, feasibility, efficacy, and persistence of non-invasive EVS to improve balance and gait performance in healthy individuals across the lifespan. Specifically, our objective is to measure balance and gait performance before, during and after exposure to single sessions and across repeated sequences of EVS at multiple study partner sites.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/20/2025
Locations: Caring Hands Caregivers, Cupertino, California
Conditions: Vestibulopathy
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Spermatogonial Differentiation Via Testicular Organoid
NCT06841861
Recruiting
Purpose: This clinical trial aims to explore the potential for human sperm production in vitro by sustaining a laboratory-cultured adult testicular environment. It also seeks to identify genetic factors contributing to human sterility and failed spermatogenesis. The study's primary objectives include: 1. Identifying genomic markers associated with sterility and failed spermatogenesis. 2. Developing an ex vivo (outside the body) testis "organ-on-a-chip" ("iTestis") to support stem cell cultivat... Read More
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
02/20/2025
Locations: The Turek Clinic, San Francisco, California
Conditions: Infertility, Male, Gene Abnormality, Sterility, Male
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VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
NCT06257706
Recruiting
Transmural healing (TMH) is recognized as a potentially important measure of Crohn's disease (CD) activity but not a formal target. Observational studies suggest that TMH may be associated with better long-term outcomes. The study will evaluate TMH using noninvasive intestinal ultrasound (IUS), a patient-friendly technique that can be performed routinely in clinical practice. The aim of the study is to determine if treating to a target of corticosteroid-free (CS-free) IUS outcomes + clinical sym... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/20/2025
Locations: TLC Clinical Research Inc - Los Angeles, Los Angeles, California
Conditions: Moderately to Severely Active Crohn's Disease, Crohn Disease, Disease Crohn
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Smoke-free Home Study in Subsidized Housing
NCT06170437
Recruiting
Comprehensive smoke-free policies have the potential to substantially reduce tobacco-related disparities among populations in subsidized housing. This study fills this gap by identifying approaches to increase the implementation of smoke-free policies in all types of subsidized housing by increasing the voluntary adoption of smoke-free homes and promoting access to smoking cessation services.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Tobacco Dependence, Tobacco Smoking
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Translational Research Center in Lung Cancer Disparities (TRACER) Project 2
NCT05490251
Recruiting
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
Gender:
MALE
Ages:
Between 18 years and 75 years
Trial Updated:
02/20/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Smoking, Smoking Behaviors, Smoking Cessation, Stress Reaction
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Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer
NCT05166616
Recruiting
This phase Ib trial tests the side effects and best dose of minnelide when given together with osimertinib for the treatment of non-small cell lung cancer that has spread to other places in the body (advanced) and has a change (mutation) in a gene called EGFR. Minnelide is a biologically inactive compound that can be broken down in the body to produce a drug that rapidly releases the active compound triptolide when exposed to phosphatases in the bloodstream. Sometimes, mutations in the EGFR gene... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Advanced Lung Non-Small Cell Carcinoma, Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8, Unresectable Lung Non-Small Cell Carcinoma
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HM15136 (efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years with Congenital Hyperinsulinism (CHI)
NCT04732416
Recruiting
This study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of HM15136 when used as add-on therapy in subjects with CHI with persistent hypoglycemia while on standard of care treatment (SoC). HM15136 will be administered once weekly in multiple doses to subjects in multiple age including pediatric to find appropriate exposure-response data.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/20/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Congenital Hyperinsulinism
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Stem Cell Transplantation in Crohn's Disease
NCT04224558
Recruiting
Unfortunately, some patients with Crohn's disease (CD) fail to respond to the best clinical treatments and some only experience temporary benefit. For severe Crohn's disease, there is an experimental treatment called "high dose immunoablation" followed by autologous hematopoietic stem cell transplantation (HSCT). This study removes over active lymphocytes (immunoablation) and replaces them using blood stem cells that have been taken from the patient's own body. The aim of the study is to reset o... Read More
Gender:
ALL
Ages:
Between 13 years and 28 years
Trial Updated:
02/20/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Crohn Disease
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Losartan + Sunitinib in Treatment of Osteosarcoma
NCT03900793
Recruiting
This study is a Phase 1/1b clinical trial that aims to determine the Maximally Tolerated Dose of Losartan and Sunitinib Combination Therapy. Patients will first be accrued to the Dose Escalation phase of the study, using a 3+3 design. Medication dosages will increase until a maximally tolerated dose is found. Patients will then be accrued to the Dose Expansion phase of the trial, where efficacy of pre-determined dose will be preliminarily assessed.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
02/20/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Osteosarcoma
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