California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Open-label Study to Evaluate the Safety of Various Dosing Regimens of MuSK-CAART for MuSK Myasthenia Gravis
Recruiting
Muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare but potentially severe disease, in which patients develop pathogenic autoantibodies that specifically target the MuSK protein in the neuromuscular junction. This phase 1 study is being conducted to evaluate the safety of various dosing regimens of an investigational cell therapy, MuSK-CAART, that can be given to patients with anti-MuSK antibody positive Myasthenia Gravis (MuSK MG), who have active disease. Various dosing reg... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: UC Irvine, Department of Neurology, Orange, California
Conditions: MuSK Myasthenia Gravis
Study to Evaluate the Efficacy and Safety of K-877-ER and CSG452 in Participants With NASH With Liver Fibrosis
Recruiting
A study to investigate the use of combination therapy with two investigational products for the treatment of adult patients with Nonalcoholic steatohepatitis (NASH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: National Research Institute, Huntington Park, California
Conditions: NASH
Study Assessing QBS72S for Treating Brain Metastases
Recruiting
This study is to evaluate the efficacy and safety of QBS72S in participants with advanced, relapsed, metastatic cancer with CNS involvement
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Stanford Cancer Institute, Palo Alto, California
Conditions: Brain Metastases, Breast Cancer, Lung Cancer, Leptomeningeal Disease, LMD
Study of PRRT in Metastatic, World Health Organization (WHO) Grade 1 or 2, SSTR Positive, GEP-NET Who Are Candidates for Cytoreductive Surgery
Recruiting
The purpose of this study is to learn about the feasibility and safety of using Peptide Receptor Radionuclide Therapy (PRRT) before and after surgical removal of a tumor. PRRT treatment is based on the administration of a radioactive product, 177-Lu DOTA-0-Tyr3-Octreotate (Lutathera®) and its use before and after surgery is thought to increase the overall survival benefit for patients with SSTR-positive gastroenteropancreatic neuroendocrine tumors GEP-NETs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Stanford Cancer Institute Palo Alto, Stanford, California
Conditions: Gastroenteropancreatic Neuroendocrine Tumor
Trial of Latex Vs Non-latex Hemorrhoid Banding
Recruiting
This study will involve the recruitment of adult patients with hemorrhoids for whom rubber band ligation is the recommended treatment. Patients will be randomized to receive banding with a latex band or non-latex band. Our goal will be to measure the performance of latex bands vs non-latex bands.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Huntington Memorial Hospital, Pasadena, California
Conditions: Hemorrhoid, Hemorrhoid Bleeding
A Study of NOE-115 in Women With Vasomotor Symptoms Due to Menopause
Recruiting
The purpose of this study is to determine the safety, tolerability, and preliminary effectiveness of NOE-115 on moderate to severe vasomotor symptoms (hot flashes) due to menopause in women.
Gender:
FEMALE
Ages:
Between 45 years and 60 years
Trial Updated:
10/24/2024
Locations: Noema PMM-201 Site #104, San Diego, California
Conditions: Menopause Syndrome, Menopause, Hot Flashes
Study of EO-3021 in Adult Patients With Solid Tumors Likely to Express CLDN18.2
Recruiting
This study is an open-label, international, multi-center, Phase 1 study in adult patients with solid tumors likely to express CLDN18.2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: City of Hope, Duarte, California
Conditions: Pancreas Neoplasm, Stomach Neoplasm, Gastrointestinal Neoplasms, Digestive System Neoplasm, Neoplasms by Site, Neoplasms
The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
Recruiting
The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/24/2024
Locations: Ragle Human Nutrition Research Center, University of California, Davis, Davis, California
Conditions: Platelet Aggregation, Spontaneous, Vascular Thrombosis
(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma
Recruiting
Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Moores Cancer Center, La Jolla, California
Conditions: Uveal Melanoma
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
Recruiting
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mor... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/24/2024
Locations: VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California
Conditions: Carcinoma, Hepatocellular, Cirrhosis
A Phase 1/2 Study of BA3071 in Patients With Solid Tumors
Recruiting
The objective of this study is to assess safety and efficacy of BA3071 in solid tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: The Angeles Clinic and Research Institute, Los Angeles, California
Conditions: NSCLC, Melanoma
Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia
Recruiting
This phase I trial tests the safety, side effects, and best dose of venetoclax in combination with a pediatric-inspired chemotherapy regimen known as C10403 in treating patients with newly diagnosed B cell acute lymphoblastic leukemia. Venetoclax may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. The C10403 regimen is composed of the chemotherapy drugs cytarabine, cyclophosphamide, daunorubicin, mercaptopurine, pegaspargase, vincristine, and methotr... Read More
Gender:
ALL
Ages:
Between 18 years and 54 years
Trial Updated:
10/24/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: B Acute Lymphoblastic Leukemia, Ph-Like Acute Lymphoblastic Leukemia