California is currently home to 5618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prostate Assessment with Restriction Spectrum Imaging (RSI) MRI
Recruiting
This single-center study will enroll 40 male participants to complete 2 diffusion magnetic resonance images within 30 days of each other.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UCSD Moores Cancer Center, La Jolla, California
Conditions: Prostate Cancer
BI-1808 As a Single Agent and with Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
Recruiting
The goal of this first in human clinical trial is to test BI-1808 administered as single agent and in combination with pembrolizumab in subjects with advanced malignancies whose disease has progressed after standard therapy. The main questions it aims to answer are: * how safe and tolerable is BI-1808 * what is maximum tolerated or administrated dose * to determine recommended dose for further clinical trials. Participants will receive infusions of BI-1808 alone or combination with pembrolizum... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Advanced Malignancies, Ovarian Cancer, T-cell Lymphoma, Melanoma
Study of Selinexor in Combination with Ruxolitinib in Myelofibrosis
Recruiting
This is a global, multicenter, 2-part study to evaluate the efficacy and safety of selinexor plus ruxolitinib in JAK inhibitor (JAKi) treatment-naïve myelofibrosis (MF) participants. The study will be conducted in two phases: Phase 1 (open-label) and Phase 3 (double-blind). Phase 1 (enrollment completed) was an open-label evaluation of the safety and recommended Phase 2 dose (RP2D) of selinexor in combination with ruxolitinib and included a dose escalation using a standard 3+3 design (Phase 1a)... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UCLA - Satellite Site, Beverly Hills, California
Conditions: Myelofibrosis
Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement
Recruiting
Fluoroscopy is performed when placing a lead during a sacral neuromodulation procedure. During lead placement, subjects will receive either conventional or experimental fluoroscopic settings. The radiation exposure will be compared between the two groups.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/03/2025
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Radiation Exposure, Overactive Bladder, Urge Incontinence, Urgency-frequency Syndrome
Reaching for Equity in Sleep Apnea Treatment (REST) Study
Recruiting
This study will test a brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of obstructive sleep apnea.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Zuckerberg San Francisco General Hospital Sleep Clinic, San Francisco, California
Conditions: Sleep Apnea
Study Assessing CLENPIQ As Bowel Preparation for Pediatric Colonoscopy
Recruiting
Bowel preparation for pediatric colonoscopy.
Gender:
ALL
Ages:
Between 2 years and 8 years
Trial Updated:
02/03/2025
Locations: Ferring Investigational Site, San Diego, California
Conditions: Bowel Preparation
Assessing Neurocognition After Cerebrovascular Intervention
Recruiting
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UCSD Medical Center, San Diego, California
Conditions: Carotid Artery Diseases, Neurocognitive Dysfunction
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
Recruiting
This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males. The proposed study design is a prospective non-randomized and uncontrolled single-center investigation. Autologous urothelial cells (UCs) and smooth muscle cells (SMCs), obtained from enrolled male subjects' bladder tissue samples, will be culture expanded in vitro and used to seed tubular PGA scaffolds to create autol... Read More
Gender:
MALE
Ages:
Between 21 years and 75 years
Trial Updated:
02/03/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Urologic Diseases, Male Urogenital Diseases, Urethral Stricture, Urethral Injury
Study for Participants Continuing From Pfizer-sponsored Palbociclib (a Study Medicine) Studies
Recruiting
The purpose of this clinical trial is to provide study medicine(s) and learn about their safety. This study is seeking participants who: * Have benefited from ongoing study treatment as determined by the study doctor in a Pfizer-sponsored palbociclib Parent Study * Must agree to follow the reproductive criteria * Are willing and able to comply with all scheduled visits, treatment plans, and other study procedures * Can give signed informed consent documents Participants in this study will cont... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: UCSF Medical Center at Mission Bay, San Francisco, California
Conditions: Breast Cancer, Head and Neck Cancer
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Recruiting
This is a Phase 1/2A, open label, multicenter, nonrandomized, multiple dose, safety, tolerability, pharmacokinetic and pharmacodynamic study of PF-07220060 administered as a single agent and then in combination with endocrine therapy. The study consists of two parts and a China and Japan monotherapy cohort. Part 1 includes dose escalation cohorts evaluating PF-07220060 as single agent or in combination with endocrine therapy or enzalutamide, as well as a food effect cohort and a DDI cohort Part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: Ellison Institute, Los Angeles, California
Conditions: Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung
Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections
Recruiting
Necrotizing soft tissue infection (NSTI) is a devastating disease that results in a high rate of in-hospital complications and despite advances in critical care, wound care, and early intervention, NSTI continues to be associated with a mortality rate of nearly 30%. The antibiotics used in this treatment are Clindamycin, Vancomycin, Piperacillin Tazobactam; these antibiotics may be administered combined or individually, based on individualized patient treatment. Although one of the tenets of man... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2025
Locations: University of California Irvine Medical Center, Orange, California
Conditions: Necrotizing Soft Tissue Infection
Mediators and Moderators of Auditory Training
Recruiting
The goal of this clinical trial is to learn how Auditory Training (AT) may help people better understand speech in noisy environments. As people get older, it becomes harder for them to hear speech clearly when there is background noise. This can be frustrating, and it can affect their independence and quality of life. AT is often used to support people with and without hearing loss, especially when a person is not a good candidate for a hearing aid or when amplification from a hearing aid does... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/31/2025
Locations: University of California, Riverside, Riverside, California
Conditions: Hearing Handicap