California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Abdominal Scar Improvement in Microsurgical Breast Reconstruction
Recruiting
Microsurgical breast reconstruction is most commonly performed with free abdominal flaps, which leave a long transverse lower abdominal scar. Due to tension across the incision, these scars frequently widen and hypertrophy. Hence, modalities that can reduce this tendency, thus, improving scar appearance are desirable. Here, we wish to investigate the impact of the Neodyne embrace device on postoperative abdominal scar appearance. The proposed study is novel in that it is the first RCT investigat... Read More
Gender:
FEMALE
Ages:
Between 18 years and 89 years
Trial Updated:
10/11/2024
Locations: Stanford University Medical Center, Stanford, California
Conditions: Cicatrix, Breast Reconstruction
Roll-over Study to Allow Continued Access to Ribociclib
Recruiting
This is an open-label, multi-center, roll-over study to evaluate the long term safety of ribociclib in combination with other drugs in participants who are participating in a Novartis sponsored global study, that has fulfilled requirements for its primary objective(s), and who in the opinion of the Investigator, would benefit from continued treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Beverly Hills Cancer Center, Beverly Hills, California
Conditions: Metastatic Breast Cancer
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
Recruiting
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Gender:
ALL
Ages:
Between 47 years and 70 years
Trial Updated:
10/11/2024
Locations: VA Palo Alto Health Care System War Related Illness and Injury Study Center, Palo Alto, California
Conditions: Gulf War Syndrome
Protonix Treatment of Maintenance of Healing in Pediatric Participants Aged 1-11 Years and 12-17 Years
Recruiting
The purpose of this study is to explore the outcomes, tolerability and safety of 2 different doses of oral pantoprazole (full healing dose, half healing dose), assigned based upon weight, for the maintenance of healing of erosive esophagitis in pediatric participants aged 1 to 17 years with endoscopically-confirmed, healed erosive esophagitis.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
10/11/2024
Locations: Childrens Hospital of Orange County, Orange, California
Conditions: Esophagitis
Confirming the Efficacy/Mechanism of Family Therapy for Children with Low Weight ARFID
Recruiting
This study is examining the efficacy and mechanism of family therapy compared to usual care for children between the ages of 6 and 12 who are diagnosed with Avoidant/Restrictive Food Intake Disorder. Preliminary data suggest that family therapy is superior to usual care and that improvement in parental self-efficacy related to feeding their children is the mechanism of treatment. In addition, this study will attempt to identify specific patient groups who respond to family therapy.
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
10/11/2024
Locations: Stanford University, Stanford, California
Conditions: Avoidant/Restrictive Food Intake Disorder
Compliant Analysis of Patient Samples and Data
Recruiting
Patients of scientific interest who have provided a commercial sample to LabCorp or one of its' affiliates will have their de-identified remnant samples and/or data used for research and development. Other commercial patients will be followed up on after informed consent is obtained.
Gender:
ALL
Ages:
All
Trial Updated:
10/11/2024
Locations: Sequenom, Inc, San Diego, California
Conditions: Pregnancy Related, Cancer, Infectious Disease
Hidradenitis Suppurativa Prospective Observational Registry and Biospecimen Repository
Recruiting
Hidradenitis suppurativa (HS) is a common and debilitating skin disease that is poorly understood and understudied. As a result, little is known about disease prognosis and few effective treatments exist for this condition. This prospective observational cohort study aims to comprehensively characterize the clinical and biological features of HS. The results of this research will provide a basis for the development of an HS clinical classification system and identification of potential treatment... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
10/11/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Hidradenitis Suppurativa
Clinical and Biological Characteristics of Hidradenitis Suppurativa
Recruiting
Hidradenitis suppurativa (HS) is a common and debilitating skin disease that is poorly understood and understudied. As a result, little is known about disease prognosis and few effective treatments exist for this condition. This prospective observational cohort study aims to comprehensively characterize the clinical and biological features of HS. The results of this research will provide a basis for the development of an HS clinical classification system and identification of potential treatment... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
10/11/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Hidradenitis Suppurativa
Specimen Collection from Pregnant Women At Increased Risk for Fetal Aneuploidy
Recruiting
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Down Syndrome, Fetal Aneuploidy
Imaging Study of [89Zr]DFO-YS5 for Detecting CD46 Positive Malignancy in Multiple Myeloma
Recruiting
This phase I trial tests the safety of \[89Zr\]DFO-YS5 positron emission tomography (PET) imaging and how well it works to detect CD46 positive cancer cells in patients with multiple myeloma. \[89Zr\]DFO-YS5 is an imaging agent called a radiopharmaceutical tracer. A radiopharmaceutical tracer uses a small amount of radioactive material that is injected into a vein to help image different areas of the body. \[89Zr\]DFO-YS5 targets a specialized protein called CD46, which is in certain multiple my... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Multiple Myeloma, Plasma Cell Myeloma
Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
Recruiting
A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of type II Diabetes (T2DM) and atherosclerosis.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
10/10/2024
Locations: Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center (The Lundquist Institute), Torrance, California
Conditions: Type II Diabetes, Atherosclerosis
Extended Bolus for Meals in a Closed-loop System
Recruiting
This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system. The new knowledge gained from this study may provide a method to allow for the proper administration of insulin over an extended period to mitigate the risk of prolonged hyperglycemia or early hypoglycemia.
Gender:
ALL
Ages:
Between 13 years and 19 years
Trial Updated:
10/10/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Type 1 Diabetes