California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors
Recruiting
This feasibility study will evaluate how well hyperpolarized 13C pyruvate magnetic resonance imaging (MRI) scan works in predicting tumor aggressiveness in participants with renal tumors. Hyperpolarized 13C pyruvate is a non-radioactive substance with potential usage in the diagnostic imaging of tumors. Hyperpolarized 13C pyruvate MRI may help doctors determine non-invasively whether a kidney tumor is a benign tumor or cancer, and if cancer, how aggressive it is. This may help doctors and partic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/06/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Benign Kidney Neoplasm, Kidney Neoplasm, Renal Cell Cancer
Cognitive Control Training for Extinction in PTSD
Recruiting
The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The project will further validate the relationship between working memory and fear extinction using novel computational and multivariate analyses that link to specific PTSD symptoms. If WMT can enhance fear exti... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/04/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Post-Traumatic Stress Disorders, Stress Disorders, Traumatic, Post Traumatic Stress Disorder, PTSD, Trauma and Stressor Related Disorders
Molecular Optimization Via Exercise (MOVE)
Recruiting
This study is to investigate characteristics of muscle, blood, and urine samples from older adults (ages 65-80) who are either sedentary or athletes performing at an elite level for their age. This observational study will include bio-specimen collection, as well as physical and cognitive function testing and body composition.
Gender:
ALL
Ages:
Between 65 years and 80 years
Trial Updated:
10/04/2024
Locations: Buck Institute for Research on Aging, Novato, California
Conditions: Aging
Esophageal Temperature During PVI Using Q-DOT Micro
Recruiting
This study will assess how two different ablation strategies, using two different ablation catheters during catheter ablation for paroxysmal atrial fibrillation, affect the temperature of the esophagus during ablation, and the risk of injury to the esophagus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Cedars-Sinai Smidt Heart Institute, Los Angeles, California
Conditions: Atrial Fibrillation Paroxysmal
A Study About How TAK-881 is Processed by the Body and Side Effects in People With Primary Immunodeficiency Diseases
Recruiting
The main aim of this study is to evaluate the PK, safety, tolerability and immunogenicity of subcutaneous (SC) administration of TAK-881 in adult and pediatric participants with PIDD and compare them to HYQVIA in participants 16 years old and older. The participants will be treated with TAK-881/HYQVIA or HYQVIA/TAK-881 with the same dose and dosing interval of immunoglobulin for up to 51 weeks (for participants greater than or equal to \[\>=\]16 years) and only with TAK-881 for up to 27 weeks (... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
10/04/2024
Locations: University of California Irvine Medical Center, Irvine, California
Conditions: Primary Immunodeficiency Diseases (PID)
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Recruiting
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Local Institution - Unk047, Anaheim, California
Conditions: Advanced NSCLC, Metastatic Lung Cancer
Time-Restricted Eating for Type II Diabetes: TRE-T2D
Recruiting
This is a randomized clinical trial to assess the feasibility and efficacy of time-restricted eating (TRE) to improve glucose regulation and cardiovascular health of participants with type 2 diabetes mellitus (T2DM). Participants will be randomized into 2 groups: 1) standard of care (SOC), in which they will continue to follow their physician's treatment plan, or 2) SOC and TRE (8-10 hours eating window).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/04/2024
Locations: Altman Clinical and Translational Research Institute, La Jolla, California
Conditions: Diabetes Mellitus, Type 2, Time Restricted Feeding, Diabetes type2
Smart Boot Use to Measure Offloading Adherence
Recruiting
The purpose of this study is to help people with diabetes who develop neuropathic diabetic foot ulcers (DFUs). These ulcers, or sores, if left untreated can increase the chance of amputation. Part of the treatment is to have the person wear a diabetic shoe or boot to help their foot heal. Sometimes people don't wear the boot like they are told. The investigators want to compare three different kinds of diabetic boots to see if they can help make it easier for people to wear their boots as instru... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California
Conditions: Diabetic Foot Ulcer
Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer
Recruiting
This research trial studies germ-line mutations in blood and saliva samples from patients with cancer. Studying samples of blood and saliva from patients with cancer in the laboratory may help doctors learn more about how inherited genetic mutations can affect cancer predisposition (an inherited increase in the risk of developing cancer), their impact on treatment response, and their role in cancer development.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Malignant Neoplasm
Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients with Inflammatory or Invasive Breast Cancer
Recruiting
This trial studies the biospecimen and medical data collection in creating a research tissue registry in patients with inflammatory or invasive breast cancer. Collecting medical data and storing samples of blood, tissue, and stool from patients with inflammatory breast cancer to study in the laboratory may help doctors find better ways to treat and study inflammatory breast cancer in the future.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Scripps - MD Anderson Cancer Center, La Jolla, California
Conditions: Inflammatory Breast Carcinoma, Invasive Breast Carcinoma, Second Primary Malignant Neoplasm
Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)
Recruiting
Advanced liver disease is a serious illness that disproportionately affects Veterans, many of whom hope for curative liver transplantation. However, too few receive a transplant and most continue to suffer from increasing symptoms and hospitalizations. The proposed project uses a whole person, Veteran-centered approach that identifies Veterans with advanced liver disease using a population-based health management system and integrates curative and early supportive care using a telemedicine-based... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/03/2024
Locations: VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California
Conditions: Liver Diseases
A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
Recruiting
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: City of Hope, Duarte, California
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands