California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
Recruiting
The primary objective is to assess overall sensitivity and specificity of Oncoguard™ Liver for hepatocellular cancer (HCC) detection in a surveillance population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: Franco Felizarta, MD, Bakersfield, California
Conditions: Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatitis B, Cirrhosis, Liver Cancer
SMR Stemless Reverse Vs SMR Reverse Shoulder System
Recruiting
The SMR Stemless Reverse is intended for total, primary shoulder joint replacement by reducing pain and restoring shoulder articular mobility function. This is a prospective, multi-center, randomized, controlled trial to demonstrate non-inferiority of the SMR Stemless Reverse to the SMR Reverse Shoulder System. Patients with joint dysfunction who continue to experience significant symptoms despite an appropriate course of non-operative management are eligible. Patients will be considered enroll... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/01/2024
Locations: Cedars-Sinai Kerlan-Jobe Institute, Los Angeles, California
Conditions: Arthroplasty, Replacement
Molecular Genetics Studies of Cancer Patients and Their Relatives
Recruiting
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
Gender:
ALL
Ages:
All
Trial Updated:
10/01/2024
Locations: John Muir Medical Center-Concord Campus, Concord, California
Conditions: Malignant Neoplasm
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
Recruiting
This study is being conducted to help the investigators better understand how the new FDA approved medication Edaravone (also known as Radicava) works in subsets of patients with ALS. The investigators are also trying to understand if there are specific ALS patients, with different presentations of ALS, who might benefit most from this medication. Also, the investigators are following specific biomarkers to determine the optimal treatment duration in patients with different forms of ALS There i... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/01/2024
Locations: Loma Linda University, Loma Linda, California
Conditions: Amyotrophic Lateral Sclerosis
GI-Challenge Study for Gastroparesis Patients and Healthy Controls
Recruiting
Gastroparesis Patients and Healthy Controls ages 20-49 will be asked to participate in an observational study measuring vagal activity following food ingestion in order to establish parameters of autonomic nerve/vagal function in healthy human subjects compared to those with gastroparesis. Information generated from this study may be used in the future to establish what is normal and abnormal enteric vagal tone and how much vagal nerve stimulation treatment may be required to help patients with... Read More
Gender:
ALL
Ages:
Between 20 years and 49 years
Trial Updated:
10/01/2024
Locations: Stanford University Medical Center, Palo Alto, California
Conditions: Gastroparesis
Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant
Recruiting
This phase I/II trial studies the side effects and best dose of multi-antigen cytomegalovirus (CMV)-modified vaccinia ankara vaccine and to see how well it works in treating pediatric patients with positive cytomegalovirus who are undergoing donor stem cell transplant. Multi-antigen CMV-modified vaccinia ankara vaccine may help people resist CMV life-threatening complications.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
10/01/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Cytomegaloviral Infection, Hematopoietic Cell Transplant Recipient
ID Of Prognostic Factors In Mycosis Fungoides/Sezary Syndrome
Recruiting
The purpose of the study is to develop a prognostic index model for the rare disease of mycosis fungoides and sezary syndrome. This will be done by collecting standardized clinical data at various institutions. The investigators hope this will enable the identification of low- and high-risk groups for survival in order to improve patient care and outcome.
Gender:
ALL
Ages:
All
Trial Updated:
10/01/2024
Locations: City of Hope, Duarte, California
Conditions: Mycosis Fungoides, Non-Hodgkin's Lymphoma
The Gastric Cancer Foundation: A Gastric Cancer Registry
Recruiting
The Gastric Cancer Registry will combine data acquired directly from patients with gastric cancer; with a family history of gastric cancer in a first or second degree relative; or persons with a known germline mutation in their CDH1 (E-Cadherin) gene via an online questionnaire with genomic data obtained from saliva, blood and tissue samples. The purpose of this registry is to gain better understanding of the causes of gastric cancer, both environmental and genetic; whether certain genomic data... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: Stanford University, School of Medicine, Stanford, California
Conditions: Gastric Cancer
Safety of Microporous Annealed Particle (MAP) Wound Matrix in Patients with Clean Surgical Wounds.
Recruiting
A randomized, open-label, investigational safety evaluation of the Microporous Annealed Particle (MAP) Wound Matrix (TT101) device as a volumetric biomaterial scaffold applied to clean wounds after skin cancer surgery with Mohs micrographic surgery (MMS) compared to control.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
09/30/2024
Locations: Cal Coast Dermatology, Encino, California
Conditions: Wound Heal
Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Intravitreal (IVT) Injection of ABI-110 (AAV2.N54-VEGF Trap) in Subjects With Neovascular (Wet) Age-Related Macular Degeneration (wAMD), Including Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV)
Recruiting
This will be a clinical study to assess initial safety and tolerability of IVT ABI-110 in patients diagnosed with wet macular degeneration (wAMD), including symptomatic macular PCV.
Gender:
ALL
Ages:
Between 50 years and 89 years
Trial Updated:
09/30/2024
Locations: California Retina Consultants, Bakersfield, California
Conditions: Neovascular (Wet) AMD
Diet and Depression
Recruiting
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/30/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
Recruiting
The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors. To accomplish this, the investigators propose obtaining image-guided measures of tissue pH and biopsied tissue in tumor areas selected for bulk resection surgery. Investigators will then correlate the imaging measurements with pH, RNA expression, protein expression, and bioenergetics measurements of key glycolytic enzymes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Glioblastoma Multiforme, Glycolytic Index, Epidermal Growth Factor Receptor