California is currently home to 5587 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
Recruiting
A pilot pharmacokinetic trial to determine the safety and efficacy of a flavored, orally administered irinotecan VAL-413 (Orotecan®) given with temozolomide for treatment of recurrent pediatric solid tumors including but not limited to neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, hepatoblastoma and medulloblastoma
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
11/24/2024
Locations: UCSF, Mission Bay - Benioff Children's Hospital, San Francisco, California
Conditions: Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Hepatoblastoma, Medulloblastoma
Quantitative Ultrasound to Assess Steatotic Liver Disease in Children
Recruiting
This research study is being conducted to find out more about advanced ultrasound techniques to non-invasively evaluate liver disease in children. The investigators are developing advanced techniques for analyzing ultrasound data and images of the liver, and they will compare it to other established methods used to evaluate the liver, including liver MRI. The investigators plan to develop and test the advanced analysis techniques using conventional full-size ultrasound machines and, if possible... Read More
Gender:
ALL
Ages:
Between 9 years and 18 years
Trial Updated:
11/22/2024
Locations: University of California San Diego, La Jolla, California
Conditions: MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
Recruiting
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue reactivity.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Smoking Cessation, Tobacco Use Disorder
Healthy Lifestyles in Bipolar Disorder: Bay Area Study
Recruiting
The goal of this clinical trial is to understand how level of adherence with time-restricted eating (TRE) predicts change in diurnal rhythms (as measured using the amplitude of diurnal peripheral clock gene expression), and how those changes predict lower mania and depressive symptoms, and downstream improvements in quality of life. The effects of diurnal amplitude of clock gene expression is expected to remain significant when controlling for change in glucose tolerance and inflammation. Partic... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California Berkeley, Berkeley, California
Conditions: Bipolar Disorder, Time Restricted Eating
Neurobehavioral Affective Control Training
Recruiting
The goal of this clinical trial is to test a new cognitive training program to improve emotion regulation in adults. The investigators' primary aim is to determine whether participating in this program addresses two key features of emotion dysregulation associated with psychiatric disorders: (1) emotion-related impulsivity and (2) rumination. The investigators will further evaluate participants' perceived acceptability and feasibility of treatment procedures. Secondarily, the investigators will... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California, Berkeley, California
Conditions: Emotional Distress, Impulsive Behavior, Mood Lability, Mood Instability, Rumination, Psychopathology, Affective Symptoms
Food FARMacia: Reducing Childhood Obesity in Households With Food Insecurity
Recruiting
The goal of this clinical trial is to test whether the Food FARMacia intervention to reduce food insecurity is feasible and accepted among families with an infant age 6 to less than 18 months receiving pediatric primary care. All participants will receive nutrition education and anticipatory guidance to support healthy meal preparation in addition to usual care.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
11/22/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Nutrition, Healthy
Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)
Recruiting
The purpose of this Phase 2, open-label, sequential dose cohort study is to evaluate the safety, efficacy, and pharmacokinetics (PK) of CRN04894 in participants with classic congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency.
Gender:
ALL
Ages:
Between 16 years and 75 years
Trial Updated:
11/22/2024
Locations: Crinetics Study Site, Pasadena, California
Conditions: Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia
Terazosin and Parkinson's Disease Extension Study
Recruiting
The purpose of this study is to investigate the long-term effects of treatment with the selective post-synaptic a1-adrenergic blocker terazosin on serial in a population of subjects with defined pre-motor Parkinson's disease (PD) risks and abnormal imaging exams. Imaging changes will be correlated to the presence and severity of motor and non-motor symptoms of PD, measured by validated clinical scales and cardiac autonomic function tests.
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
11/22/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Symptomatic Parkinson Disease, REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease
Terazosin Effect on Cardiac Changes in Early Parkinson's Disease
Recruiting
Parkinson's disease (PD) is characterized by many non-motor symptoms that occur several years before the diagnosis, in particular idiopathic REM behavior disorder (iRBD), which is associated with autonomic impairment. The purpose of this study is to investigate the effect of treatment with the selective post-synaptic a1-adrenergic blocker terazosin on 123I-MIBG myocardial uptake in a population of subjects with defined pre-motor PD risks (i.e. hyposmia and RBD) and abnormal baseline 123I-MIBG up... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
11/22/2024
Locations: Michele L Lima Gregorio, Los Angeles, California
Conditions: REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease, Symptomatic Parkinson Disease
Safety and Preliminary Efficacy of OBT076 in Recurrent/Metastatic CD205+ Solid Tumors
Recruiting
The purpose of this study is to evaluate OBT076, which is a drug that combines an antibody with an anti-cancer drug. This class of drugs are called Antibody-Drug Conjugates (ADC). Antibodies are normally produced in the human body by the immune system to fight infections but can be designed to target cancer cells and deliver an anti-cancer drug. OBT076 is composed of an antibody that targets the CD205 protein on cancer cells and delivers an anti-cancer drug which can kill them. OBT076 is an "Inv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Cedars-Sinai, Los Angeles, California
Conditions: Solid Tumor
An Objective Assessment Tool for Evaluating Functioning in Older Adults
Recruiting
The Investigators are seeking your consent to participate in research investigating the development of a mobile application that enhances physical and cognitive assessments. This is in response to the growing significance of the Short Physical Performance Battery (SPPB) in Alzheimer's Disease and Related Dementias (AD/ADRD) research. The SPPB has proven its value in evaluating lower extremity function and mobility in older adults, providing predictive insights into declines in daily living acti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Clinical Excellence Research Center, Palo Alto, California
Conditions: Alzheimer Disease
Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer
Recruiting
Multi-site randomized trial of the THRIVE digital health application versus usual care to evaluate the effect of THRIVE on quality of life (QOL), physical and psychological symptoms, coping, and self-efficacy in 250 patients with newly diagnosed advanced lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Lung Cancer