California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy
Recruiting
The goal of this treatment study is to determine if doing lateral pharyngoplasty with tonsillectomy is better for children than doing tonsillectomy alone. The main questions it aims to answer are: * Do children experience less pain after surgery when lateral pharyngoplasty is performed with tonsillectomy compared to tonsillectomy alone? * Do children eat/drink better when lateral pharyngoplasty is performed with tonsillectomy compared to tonsillectomy alone? * Is there a lower risk of bleeding... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
09/30/2024
Locations: Loma Linda University Professional Building - Murrieta, Murrieta, California
Conditions: Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children, Sleep Apnea, Obstructive, Tonsillitis, Tonsillar Hypertrophy, Tonsil Stone, Tonsil Disease
GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2
Recruiting
Patients with Small Cell Lung Cancer, High Risk Neuroblastoma, Sarcoma and Malignant Melanoma will be treated with GD2-SADA:177Lu-DOTA complex(The IMP is a two-step radioimmunotherapy, delivered as two separate products GD2-SADA and 177Lu-DOTA) to assess safety and tolerability
Gender:
ALL
Ages:
16 years and above
Trial Updated:
09/30/2024
Locations: City of Hope National Medical Center, Duarte, California
Conditions: SCLC, Malignant Melanoma, Sarcoma, High Risk Neuroblastoma
Do Endotypes Predict Response and Sequelae in OSA Patients
Recruiting
This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/30/2024
Locations: Altman Clinical and Translational Research Institute Building, La Jolla, California
Conditions: Obstructive Sleep Apnea, Sleep Apnea, Sleep Apnea, Obstructive, Sleep, Sleep Disorder
Melatonin Adolescent Research Study
Recruiting
The present study will use a within-person, randomized cross-over experimental design to test the effects of exogenous melatonin supplementation on the sleep and daytime functioning of typically developing adolescents with short or disrupted sleep of behavioral origins (i.e., difficulty falling asleep, staying asleep, or premature waking resulting in short or disrupted sleep not attributed to an organic sleep condition).
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
09/30/2024
Locations: Loma Linda University, Loma Linda, California
Conditions: Sleep Disorders in Children
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Recruiting
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to relieve OA and its associated issues. Traditional surgical interventions have not yielded convincing long-term outcomes, including total joint replacement surgeries and medical management of the supportive structures. This study is to use a person's own stem/stromal Cel... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/30/2024
Locations: Hemwall Center for Orthopedic Regenerative Medicine, Valencia, California
Conditions: Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints, Osteoarthritis, Hip, Osteoarthritis - Ankle/Foot
Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer
Recruiting
The purpose of this phase 2 research study is to determine whether a combination of chemotherapy drugs plus radiation therapy, given before surgery in resectable pancreactic cancer, can help to increase the chances of surgeons achieving and R0 resection. The chemotherapy drugs used are gemcitabine and nab-paclitaxel. These drugs are both approved by the FDA for use in treating adults with pancreatic adenocarcinoma. The investigational portion of this study is providing the chemotherapy drugs and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Pancreas Adenocarcinoma, Resectable Pancreatic Cancer
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
Recruiting
The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint. The inflammation is associated with increased abnormal blood flow going to the specific area of pain. If the investigator can reduce the blood flow, the inflammation can be reduced and the pain can be controlled. The GAE procedure is an experimental procedure to decreas... Read More
Gender:
ALL
Ages:
Between 40 years and 79 years
Trial Updated:
09/28/2024
Locations: UCLA Santa Monica Hospital, Santa Monica, California
Conditions: Knee Osteoarthritis, Degenerative Joint Disease of Knee
Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
Recruiting
This clinical trial uses a type of imaging scan called magnetic resonance imaging (MRI) to study brain tumor biology in patients with glioblastoma that can be removed by surgery (resectable). Malignant gliomas are the second leading cause of cancer mortality in people under the age of 35 in the United States. Glioblastoma is a type of malignant glioma with very poor patient prognosis. There are currently only about 3 drugs approved by the Food and Drug Administration (FDA) for the treatment of g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Glioblastoma, Recurrent Glioblastoma, Resectable Glioblastoma
Efficacy of mHealth Applications in Weight Management in a Population Affected by Overweight or Obesity
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes in patients with overweight and obesity. This study will involve a 6-month long commitment where participants will be expected to use an mHealth app daily, weigh themselves and check their fasting blood glucose levels every morning.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/27/2024
Locations: San Diego State University, San Diego, California
Conditions: Overweight and Obesity
Efficacy of Using Mobile Health Applications for Health
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and type II diabetes outcomes in type 2 diabetics. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the same time, and check their blood glucose readings daily before and after meals for at least three meals in the day.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/27/2024
Locations: San Diego State University, San Diego, California
Conditions: Diabetes Mellitus, Type 2, Obesity
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and the subsequent benefit of improving type II diabetes outcomes in a low socioeconomic Hispanic population. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the same time, and check their blood glucose readings daily before and after meals for at least three meals in the day.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/27/2024
Locations: San Diego State University, San Diego, California
Conditions: Diabetes Mellitus, Type 2, Obesity
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Recruiting
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.
Gender:
ALL
Ages:
All
Trial Updated:
09/27/2024
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Aortic Valve Insufficiency, Aortic Valve Stenosis