California is currently home to 5585 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis
Recruiting
The purpose of this research study is to examine the effectiveness of using the Iovera Smart Time 190, for ultrasound-guided cryoneurolysis, in trauma patients 18-64 years old with rib fractures that are not candidates for surgical stabilization. This will offer patients the benefits of cryoneurolysis of the intercostal nerves, thereby providing short and long term pain control while their ribs heal. The Iovera Smart Tip 190 is FDA approved for cryoneurolysis.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
11/20/2024
Locations: Stanford Hospital and Clinics, Palo Alto, California
Conditions: Rib Fractures
A Study of Amivantamab in People with Esophagogastric Cancer
Recruiting
The purpose of this study is to see whether the study drug, amivantamab, is an effective treatment for people with EGFR- or MET-amplified esophagogastric cancer. The researchers will also look at whether amivantamab is a safe treatment that causes few or mild side effects in participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Esophagogastric Cancer
Decreasing Emergence Agitation With Personalized Music
Recruiting
The purpose of the study is to assess the impact of personalized music on emergence agitation (EA), as measured by Pediatric Anesthesia Emergence Delirium scores in pediatric patients recovering from elective procedures under general anesthesia. Personalized music may help to decrease EA in children undergoing elective surgeries under general anesthesia by decreasing perioperative anxiety and minimizing perceived pain. The study has the potential to improve perioperative care by improving safet... Read More
Gender:
ALL
Ages:
Between 3 years and 9 years
Trial Updated:
11/20/2024
Locations: Stanford University, Stanford, California
Conditions: Surgical Procedure, Unspecified
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
Recruiting
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS). Specifically, we will investigate how tDCS combined with cognitive training improves deficits to attention and working memory in Active Duty Service Members with a history of mild traumatic brain injury (TBI). Measures of attention-related brain activity, neurocognitive assessments, and self-re... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
11/20/2024
Locations: Naval Medical Center San Diego, San Diego, California
Conditions: Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment
Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
Recruiting
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California
Conditions: Frailty, Sarcopenia
Impact of the Coronavirus (COVID-19) on Patients With Cancer
Recruiting
The purpose of this study is to understand the impact of COVID-19 on patients with cancer through a survey.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/20/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Cancer, COVID-19
Gadolinium Contrast-enhanced Abbreviated MRI (AMRI) Vs. Standard Ultrasound for Hepatocellular Carcinoma (HCC) Surveillance in Patients with Cirrhosis
Recruiting
This study compares gadolinium contrast-enhanced Abbreviated MRI (AMRI) to standard ultrasound for Hepatocellular Carcinoma (HCC) screening and surveillance in subjects with liver cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Liver Cancer, Liver Cirrhoses, Liver Carcinoma
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
Recruiting
This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. The main goals of this study are to: * Find the recommended dose(s) of BT5528 that can be given safely to participants alone and in combination with nivolumab * Learn more about the side effects of BT5528 * Learn about how effective BT5528 is for the treatment of ovarian cancer, urothelial/bladder cancer, lung cance... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: California Cancer Associates for Research and Excellence, Inc., Encinitas, California
Conditions: Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer, Head and Neck Cancer, Triple Negative Breast Cancer, Gastric/Upper Gastrointestinal Cancer
Characteristics and Inflammatory Markers in Children with Eosinophilic Esophagitis (EoE)
Recruiting
Single center observational and specimen banking study for children with eosinophilic esophagitis EoE to gauge natural history and inflammatory markers
Gender:
ALL
Ages:
Between 1 year and 65 years
Trial Updated:
11/20/2024
Locations: Rady Children's Hospital San Diego, San Diego, California
Conditions: Eosinophilic Esophagitis
FDG PET/CT in Monitoring Very Early Therapy Response in Patients With Glioblastoma
Recruiting
This pilot clinical trial studies fluordeoxyglucose (fludeoxyglucose) F-18 (FDG) positron emission tomography (PET)/computed tomography (CT) in monitoring very early therapy response in patients with glioblastoma. Diagnostic procedures, such as FDG PET/CT, may help measure a patient's response to earlier treatment. Chemotherapy can induce very rapid changes to the tumor's glucose consumption which can be measured with imaging. FDG PET/CT shortly after the start of therapy may help identify very... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/20/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Glioblastoma
Development of Radiation Free Whole Body Magnetic Resonance (MR) Imaging Technique for Staging Children With Cancer
Recruiting
A research study on the diagnosis of spread of disease for children who have been diagnosed with solid tumors using a new whole body imaging technique and a new MR contrast agent (ferumoxytol). Standard tests that are used to determine the extent and possible spread of a child's disease include magnetic resonance (MR) imaging, computed tomography (CT), Positron Emission Tomography (PET) as well as bone scanning, and metaiodobenzylguanidine (MIBG) scanning. The purpose of this study is to determi... Read More
Gender:
ALL
Ages:
Between 6 years and 40 years
Trial Updated:
11/20/2024
Locations: Stanford University Cancer Institute, Stanford, California
Conditions: Cancer
Phase 1 Study of PRX019 in Healthy Adult Volunteers
Recruiting
The purpose of this study is to assess the safety and tolerability of PRX019 in healthy adult participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/19/2024
Locations: Local Institution, Los Alamitos, California
Conditions: Healthy Participants Study