California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Do Endotypes Predict Response and Sequelae in OSA Patients
Recruiting
This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/30/2024
Locations: Altman Clinical and Translational Research Institute Building, La Jolla, California
Conditions: Obstructive Sleep Apnea, Sleep Apnea, Sleep Apnea, Obstructive, Sleep, Sleep Disorder
Melatonin Adolescent Research Study
Recruiting
The present study will use a within-person, randomized cross-over experimental design to test the effects of exogenous melatonin supplementation on the sleep and daytime functioning of typically developing adolescents with short or disrupted sleep of behavioral origins (i.e., difficulty falling asleep, staying asleep, or premature waking resulting in short or disrupted sleep not attributed to an organic sleep condition).
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
09/30/2024
Locations: Loma Linda University, Loma Linda, California
Conditions: Sleep Disorders in Children
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Recruiting
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to relieve OA and its associated issues. Traditional surgical interventions have not yielded convincing long-term outcomes, including total joint replacement surgeries and medical management of the supportive structures. This study is to use a person's own stem/stromal Cel... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/30/2024
Locations: Hemwall Center for Orthopedic Regenerative Medicine, Valencia, California
Conditions: Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints, Osteoarthritis, Hip, Osteoarthritis - Ankle/Foot
Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer
Recruiting
The purpose of this phase 2 research study is to determine whether a combination of chemotherapy drugs plus radiation therapy, given before surgery in resectable pancreactic cancer, can help to increase the chances of surgeons achieving and R0 resection. The chemotherapy drugs used are gemcitabine and nab-paclitaxel. These drugs are both approved by the FDA for use in treating adults with pancreatic adenocarcinoma. The investigational portion of this study is providing the chemotherapy drugs and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Pancreas Adenocarcinoma, Resectable Pancreatic Cancer
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
Recruiting
The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint. The inflammation is associated with increased abnormal blood flow going to the specific area of pain. If the investigator can reduce the blood flow, the inflammation can be reduced and the pain can be controlled. The GAE procedure is an experimental procedure to decreas... Read More
Gender:
ALL
Ages:
Between 40 years and 79 years
Trial Updated:
09/28/2024
Locations: UCLA Santa Monica Hospital, Santa Monica, California
Conditions: Knee Osteoarthritis, Degenerative Joint Disease of Knee
Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
Recruiting
This clinical trial uses a type of imaging scan called magnetic resonance imaging (MRI) to study brain tumor biology in patients with glioblastoma that can be removed by surgery (resectable). Malignant gliomas are the second leading cause of cancer mortality in people under the age of 35 in the United States. Glioblastoma is a type of malignant glioma with very poor patient prognosis. There are currently only about 3 drugs approved by the Food and Drug Administration (FDA) for the treatment of g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Glioblastoma, Recurrent Glioblastoma, Resectable Glioblastoma
Efficacy of mHealth Applications in Weight Management in a Population Affected by Overweight or Obesity
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes in patients with overweight and obesity. This study will involve a 6-month long commitment where participants will be expected to use an mHealth app daily, weigh themselves and check their fasting blood glucose levels every morning.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/27/2024
Locations: San Diego State University, San Diego, California
Conditions: Overweight and Obesity
Efficacy of Using Mobile Health Applications for Health
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and type II diabetes outcomes in type 2 diabetics. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the same time, and check their blood glucose readings daily before and after meals for at least three meals in the day.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/27/2024
Locations: San Diego State University, San Diego, California
Conditions: Diabetes Mellitus, Type 2, Obesity
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
Recruiting
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and the subsequent benefit of improving type II diabetes outcomes in a low socioeconomic Hispanic population. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the same time, and check their blood glucose readings daily before and after meals for at least three meals in the day.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/27/2024
Locations: San Diego State University, San Diego, California
Conditions: Diabetes Mellitus, Type 2, Obesity
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Recruiting
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.
Gender:
ALL
Ages:
All
Trial Updated:
09/27/2024
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Aortic Valve Insufficiency, Aortic Valve Stenosis
Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma
Recruiting
This clinical trial constructs and tests a novel multinuclear metabolic magnetic resonance imaging (MRI) sequence in patients with glioma (brain tumor) that is newly diagnosed or has come back (recurrent). This trial aims to develop new diagnostic imaging technology that may bridge gaps between early detection and diagnosis, prognosis, and treatment in brain cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Glioma, Malignant Glioma, Recurrent Glioma, Recurrent Malignant Glioma
Rituximab-pvvr and Abatacept Vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
Recruiting
The study is a two-arm, multicenter, double-blinded clinical trial testing sequential therapy with rituximab-pvvr followed by abatacept versus rituximab-pvvr alone in new onset T1D. The primary objective is to test whether the C-peptide response to a 2-hour mixed meal tolerance test, will be improved in participants with new onset T1D who are treated with Abatacept after Rituximab-pvvr compared to those treated with Rituximab-pvvr and placebo 24 months after enrollment.
Gender:
ALL
Ages:
Between 8 years and 45 years
Trial Updated:
09/27/2024
Locations: Childrens Hospital of Orange County, Orange, California
Conditions: Type 1 Diabetes Mellitus