California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Carboplatin or Olaparib for BRcA Deficient Prostate Cancer
Recruiting
This is an unblinded, randomized clinical study comparing the efficacy of DNA damaging chemotherapy using carboplatin, to standard of care therapy for patients who have metastatic castrate resistant prostate cancer. This trial will use olaparib or carboplatin as initial therapy with crossover to the alternate or second-line drug after first progression for patients with tumors containing BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D, or RAD54L inactivating mutations. P... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/13/2024
Locations: VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California
Conditions: Metastatic Castrate Resistant Prostate Cancer, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D, or RAD54L Mutations
Pre-Visit Positive Imagery in Reducing Dental Anxiety
Recruiting
The purpose of this study is to determine whether pre-visit positive imagery has an impact in decreasing dental anxiety and fear in pediatric patients as well as increasing patient cooperation during treatment visits. Patients needing at least 1 composite filling with nitrous and local anesthetic will receive a picture book if they are selected in the experimental group, and no picture book if they are in the control group. Patients will be asked to be fill out a pre-operative survey and post-op... Read More
Gender:
ALL
Ages:
Between 4 years and 6 years
Trial Updated:
09/12/2024
Locations: Herman Ostrow School of Dentistry of USC, Los Angeles, California
Conditions: Dental Anxiety
Two-fraction HDR Monotherapy for Localized Prostate Cancer
Recruiting
This is a single center single arm prospective pilot study investigating the safety of high dose rate (HDR) brachytherapy as monotherapy delivered in 2 fractions 3 hours apart. HDR monotherapy has been established as safe and effective in this context, however previous studies have delivered 2 fractions on separate days, or at least 6 hours apart. Clinically, this regimen, if shown to be safe and effective in future studies, has the potential to reduce operative resources and logistical stresses... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Prostate Adenocarcinoma, Localized Prostate Carcinoma
A Study ATG-101 in Patients With Metastatic/Advanced Solid Tumors and Mature B-cell Non-Hodgkin Lymphomas
Recruiting
This is a First-in-Human Phase I trial of ATG-101 in Patients with Metastatic/Advanced Solid Tumors and Mature B-cell Non-Hodgkin Lymphomas.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Advanced Solid Tumor, Metastatic Solid Tumor, Mature B-cell Non-Hodgkin Lymphoma
Selinexor and Backbone Treatments of Multiple Myeloma Patients
Recruiting
This study will independently assess the efficacy and safety of 11 combination therapies in 12 arms, in dose-escalation/-evaluation and expansion phases, for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) and newly diagnosed multiple myeloma (NDMM). The combinations to be evaluated are: * Arm 1: Selinexor + dexamethasone + pomalidomide (SPd); enrollment complete * Arm 2: Selinexor + dexamethasone + bortezomib (SVd); enrollment complete * Arm 3: Selinexor + dexamethas... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Jonnsson Comprehensive Cancer Center / University of Los Angeles, Los Angeles, California
Conditions: Multiple Myeloma
Evaluation of the Performance and Acceptability of a Synthetic Polyisoprene Male Condom Compared to a Natural Rubber Latex Condom
Recruiting
This study is a masked (investigators, research staff), two-way crossover, randomized to sequence of use study designed to evaluate the acceptability and functional performance (breakage, slippage) of a silicone lubricated polyisoprene condom and a silicone lubricated natural rubber latex condom.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
09/11/2024
Locations: Essential Access, Berkeley, California
Conditions: Condom Use
Peripheral Bypass Trial for Completion Control
Recruiting
The goal of the study is to identify and validate flow measurement and ultrasound images in patients undergoing vein bypass surgery below-knee and above ankle
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: University of California, San Francisco, California
Conditions: Chronic Limb-Threatening Ischemia
Encore PFO Closure Device - The PerFOrm Trial
Recruiting
The objective of this study is to establish reasonable assurance of safety, effectiveness, and noninferiority of the Encore PFO closure device when compared to any investigator chosen FDA-approved PFO closure device.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
09/11/2024
Locations: Southern CA Permanente Medical Group - Kaiser San Diego and Scripps Memorial Hospital, La Jolla, California
Conditions: Patent Foramen Ovale, Cryptogenic Stroke
Music Training and Child Development Study
Recruiting
This proposed study aims to provide a definitive answer to whether music training benefits brain development, particularly brain inhibition control circuitry and its related health outcomes using a randomized control trial design. In the study, 114 Hispanic children between ages 6-8 from underserved communities of LA will be randomly assigned to a 24-month:(1) community-focused after school music training group focused on a traditional strings curriculum at the Colburn school in Los Angeles (MG... Read More
Gender:
ALL
Ages:
Between 6 years and 8 years
Trial Updated:
09/11/2024
Locations: Brain and Creativity Institute, Los Angeles, California
Conditions: Music
Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
Recruiting
This study will evaluate the safety and effectiveness of the Globe® Pulsed Field System for treating patients with symptomatic paroxysmal or persistent atrial fibrillation (AF).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/11/2024
Locations: Sutter Health - California Pacific Medical Center, San Francisco, California
Conditions: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2
Recruiting
Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora. Preliminary data demonstrates that a transperineal MRI-targeted biopsy approach under local anesthesia compared to the standard practice transrectal MRI-targeted prostate biopsy has a much lower risk of infection, comparable pain/discomfort and may improve detection of prostate cancer. This randomiz... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Infection
Effect of Myofunctional Therapy on OSA
Recruiting
The primary medical therapies for patients with Obstructive Sleep Apnea syndrome (OSA) require the use of medical devices on a nightly basis to help control breathing during sleep, which can be difficult for patients with mild-to-moderate disease. Because many patients use these therapies on a limited basis, or stop using them altogether, they continue to be at increased risk of the consequences of untreated OSA. Untreated and undertreated OSA compounds the risk of OSA consequences over time, pa... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/11/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Obstructive Sleep Apnea