California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
Recruiting
The primary purpose of this study is to evaluate the efficacy of ION363 on clinical function and survival in carriers of fused in sarcoma mutations with amyotrophic lateral sclerosis (FUS-ALS).
Gender:
ALL
Ages:
10 years and above
Trial Updated:
11/08/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Amyotrophic Lateral Sclerosis
A Nutritional Intervention for Body, Brain, and Longevity Effects (NIBBLE)
Recruiting
The study aims to evaluate the safety, feasibility, and efficacy of six-month fasting-mimicking (FMD) intervention in middle-aged adults at elevated risk for Alzheimer's disease due to the apolipoprotein (APOE) ε4 allele. Participants randomly assigned to the active intervention will consume a FMD for 5-days each month over a period of 6-months.
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
11/07/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Cerebral Blood Flow, APOE 4
Role of Race in Nutritional Approach in Men on ADT
Recruiting
There is a well-documented association between androgen deprivation therapy (ADT) and cardiovascular morbidity. A majority of men on ADT gain weight contributing to an increase in cardiovascular risk factors (CVRFs) and cardiovascular morbidity. Dietary intervention combined with exercise have shown success in reducing weight/fat mass and improving cardiovascular risk factors (CVRF). There is little data on whether African American men would respond to diet and exercise interventions differently... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Greater Los Angeles Division of Veterans Affairs, Los Angeles, California
Conditions: Prostate Cancer Metastatic Disease
A Study to Investigate the Efficacy and Safety of NSI-8226 in Adults with Eosinophilic Esophagitis
Recruiting
Phase 2 study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of solrikitug in adult participants with eosinophilic esophagitis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/07/2024
Locations: Research Site 1015, San Diego, California
Conditions: Eosinophilic Esophagitis (EoE)
Starting Technology in At Risk Type 1 Diabetes Study
Recruiting
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c\>8.5%). In order to examine whether diabetes technology can reduce diabetes care burdens and enhance outcomes among some of highest need patients, diabetes technology clinical trials must be expanded beyond the very select populations included in studies thus far (ie., mostly White, h... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: UCLA, Santa Monica, California
Conditions: Diabetes Mellitus, Type 1
A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia
Recruiting
This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-risk JMML patients will receive trametinib, azacitidine, fludarabine, and cytarabine.
Gender:
ALL
Ages:
Between 1 month and 21 years
Trial Updated:
11/07/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Leukemia, Juvenile Myelomonocytic, JMML, JCML, Neurofibromatosis 1, CBL Syndrome
Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms
Recruiting
The main purpose of this study is to determine the effectiveness of the study drug pacritinib in people with relapsed or refractory lymphoproliferative disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: City of Hope, Duarte, California
Conditions: T-Cell Neoplasm, Lymphoproliferative Disorders
Development of a Research Infrastructure for Understanding and Addressing Multiple Myeloma Disparities
Recruiting
The objectives of the proposed study are to develop and evaluate protocols for ethnic/racial minority-specific research using cancer registry data. In conjunction with the Cancer Registry of Greater California (CRGC), the investigators have developed procedures to identify, recruit, and survey ethnic/racial minority patients with MM. To pilot the study, the investigators aim initially to test the feasibility of this protocol by contacting 400 eligible patients (100 African Americans, 100 Latinos... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/07/2024
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Multiple Myeloma
9-ING-41 in Pediatric Patients with Refractory Malignancies.
Recruiting
9-ING-41 has anti-cancer clinical activity with no significant toxicity in adult patients. This Phase 1 study will study its efficacy in paediatric patients with advanced malignancies.
Gender:
ALL
Ages:
22 years and below
Trial Updated:
11/07/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Refractory Cancer, Refractory Neoplasm, Cancer Pediatric, Refractory Tumor, Pediatric Cancer, Pediatric Brain Tumor, Neuroblastoma, Neuroblastoma Recurrent, Pediatric Lymphoma, Pediatric Meningioma, Diffuse Intrinsic Pontine Glioma
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Rady Children's Hospital, San Diego, California
Conditions: Congenital Disorders of Glycosylation
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy
Recruiting
This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/07/2024
Locations: University of California, Davis, Sacramento, California
Conditions: Epilepsy, Post-Traumatic
Controlled Desaturation Study for Perin Health Patch Validation
Recruiting
This study aims to test the accuracy of the Perin Health Patch (PHP), a non-invasive, chest-worn device that measures blood oxygen levels, by comparing its readings to a standard pulse oximeter device. The PHP device uses light sensors to measure blood oxygen saturation (SpO2), similar to how standard pulse oximeters work, and could allow for continuous remote monitoring at home. Participants in this study will breathe low-oxygen air through a mask to simulate different oxygen levels in a contro... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/06/2024
Locations: Perin Health Devices, Woodland Hills, California
Conditions: Oxygen Saturation Measurement