California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
Recruiting
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk during the lateral lumbar interbody fusion (LLIF) procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: Alphatec Spine Inc., Carlsbad, California
Conditions: Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Comparison of Type 2 Diabetes Pharmacotherapy Regimens
Recruiting
This study is designed to help patients with type 2 diabetes and their clinicians: (a) identify which glucose lowering medications have the most favorable effects on heart health and other patient-important outcomes, (b) inform the timing of medication initiation, and (c) identify whether medication benefits apply equally to all adults with type 2 diabetes, or may be different based on age, sex, race/ethnicity, baseline heart health status, baseline renal function, or other factors.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/22/2024
Locations: Romain S. Neugebauer, Oakland, California
Conditions: Type 2 Diabetes Mellitus, Cardiovascular Diseases
Imaging Immune Activation in COVID-19
Recruiting
This is a single center, single arm exploratory imaging study involving up to two intravenous microdoses of \[18F\]F-AraG (the second tracer dose is optional) followed by whole-body PET-CT imaging in participants with convalescent COVID-19. Up to 80 participants will be enrolled over an accrual period of approximately 48 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Covid19, SARS-CoV Infection
Imaging Immune Activation in HIV by PET-MR
Recruiting
This is a single center exploratory imaging study involving one intravenous microdose of \[18F\]F-AraG followed by whole-body positron emission tomography-magnetic resonance (PET-MR) imaging in HIV infected individuals to determine the anatomical distribution of the PET tracer. Participants will be enrolled if they were treated during early or late HIV infection. In addition, individuals not on antiretroviral therapy (ART) or with HIV-1 plasma RNA levels \>5,000 copies/mL will be enrolled. Up to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: HIV Infections
Hyperpolarized 13C MRI to Predict Response in Pancreatic Cancer
Recruiting
This study evaluates an investigational scan called hyperpolarized carbon-13 pyruvate magnetic resonance imaging (MRI) in assessing treatment response in patients with pancreatic ductal carcinoma (PDA) that has spread to nearby tissue or lymph nodes (locally advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). MRI is a standard scan that helps doctors see tumors, organs, tissue, and bone. Standard contrast agents (e.g., gadolinium) are... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma
Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity
Recruiting
Non-randomized, two-arm stepped-wedge trial of a multi-level colorectal cancer screening intervention.
Gender:
ALL
Ages:
Between 45 years and 64 years
Trial Updated:
10/21/2024
Locations: AltaMed Health Services Corporation, Los Angeles, California
Conditions: Colorectal Cancer
Group-Based Psychological Treatments Over Video Conference for Older Veterans With Chronic Pain
Recruiting
This study is being performed to compare the effects of three types of group-based psychological treatments delivered over video telehealth for chronic musculoskeletal pain in older U.S. military Veterans. The three types of psychological treatments are: Cognitive-Behavioral Therapy (CBT), Emotional Awareness and Expression Therapy (EAET), and Mindfulness Meditation (MM). In addition, the investigators will evaluate which patients respond best to each treatment and how each treatment works. The... Read More
Gender:
ALL
Ages:
Between 60 years and 95 years
Trial Updated:
10/21/2024
Locations: VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California
Conditions: Chronic Musculoskeletal Pain
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank diagnostic criteria, who are experiencing wearing off symptoms and levodopa-induced dyskinesia.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/21/2024
Locations: Clinical Site, Irvine, California
Conditions: Parkinson Disease
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)
Recruiting
The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.
Gender:
ALL
Ages:
30 months and below
Trial Updated:
10/21/2024
Locations: UCSF Benioff Children's Hospital Oakland, Oakland, California
Conditions: Canavan Disease
Administration of Allogeneic-MSC in Patients with Non-Ischemic Dilated Cardiomyopathy
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called human allogeneic mesenchymal stem cell therapy.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/21/2024
Locations: Stanford University, Stanford, California
Conditions: Non-ischemic Dilated Cardiomyopathy
Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor
Recruiting
The purpose of this study is to evaluate the safety and clinical activity of nivolumab and relatlimab in patients with microsatellite instability high (MSI-H) solid tumors refractory to prior PD-(L)1 therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Refractory MSI - H Solid Tumors Prior of PD-(L) 1 Therapy, MSI-H Tumors
An Evaluation of LASIK, SMILE and PRK Surgery in Physicians
Recruiting
The principle investigator is evaluating self-reported quality of vision and quality of life in physicians undergoing LASIK, SMILE and PRK surgery.
Gender:
ALL
Ages:
Between 21 years and 62 years
Trial Updated:
10/21/2024
Locations: Byers Eye Institute at Stanford, Palo Alto, California
Conditions: Nearsightedness, Farsightedness, Astigmatism