California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.
Recruiting
The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. The main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. All participants will answer questions on Day 1, before treatment, and on 7-day after treatment, about: * Amount and quality of pain * Interference wi... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/19/2024
Locations: Sean Wollaston, MD, Valley Village, California
Conditions: Sciatica Acute, Lumbar Spinal Stenosis
Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands
Recruiting
The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
09/19/2024
Locations: Imaging Research Center, Sacramento, California
Conditions: Healthy
Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction
Recruiting
The primary goal of this proposal is to validate a novel genomic and microbiome predictive model that may be used to assess a person's risk of developing opioid use disorder (OUD). The following will be tested: (1) MODUS (Measuring risk for Opioid use Disorder Using SNPs), which is a genomic panel consisting of a set number of proven single nucleotide polymorphisms (SNP) that utilizes machine learning to determine an individual's risk; and (2) MICROUD (MICRObiome for Opioid Use Disorder), which... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Opioid Use Disorder, Addiction, Opioid
A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader (LDD) of BCL6 (BCL6 LDD), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Relapsed/Refractory Non-Hodgkin Lymphoma
Neurophysiologic Biomarkers for Cognitive Rehabilitation
Recruiting
Cognitive symptoms of schizophrenia interfere with daily life-from managing self-care, to more complex tasks like taking medications and living independently. Unfortunately, these cognitive symptoms are not corrected by 'standard of care' treatments (antipsychotic medications), although some schizophrenia patients may experience modest clinical and cognitive benefits from cognitive remediation. To enhance the clinical impact of cognitive remediation and other rehabilitative interventions for Vet... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/18/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Schizophrenia Spectrum Disorders
Rheumatoid Arthritis Shared Decision Making
Recruiting
Shared decision making is the first overarching principle for the treat to target guidelines for rheumatoid arthritis (RA) and has been proposed as a potential mechanism to reduce health disparities, however there is little evidence to inform effective ways to implement this practice in the care of Veterans with RA. The purpose of this project is to evaluate the effectiveness of a multi-component shared decision making intervention on RA disease activity, adherence to RA medications and patient... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California
Conditions: Rheumatoid Arthritis
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients with Severe Sickle Cell Disease
Recruiting
This is an open label, non-randomized, 2-center, phase 1/2 trial of a single infusion of sickle allele modified cluster of differentiation (CD34+) hematopoietic stem progenitor cells (HSPCs) in subjects with in subjects ≥12 years old to 35 years old severe Sickle Cell Disease (SCD). The study will evaluate the hematopoietic stem cell transplantation (HSCT) using CRISPR/Cas9 edited red blood cells (known as CRISPR_SCD001 Drug Product).
Gender:
ALL
Ages:
Between 12 years and 35 years
Trial Updated:
09/18/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Sickle Cell Disease
Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients
Recruiting
The purpose of this study is to test any good and bad effects of the study drug called brentuximab vedotin at a lower dose than is FDA-approved.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Stanford University Medical Center, Stanford, California
Conditions: Mycosis Fungoides, Lymphomatoid Papulosis, Sezary Syndrome
Neuroblastoma Maintenance Therapy Trial
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg/m2 ± 250 mg/m2 BID (strata 1, 2, 3, and 4) OR 2500 mg/m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
09/18/2024
Locations: UCSF Benioff Children's Hospital Oakland-, Oakland, California
Conditions: Neuroblastoma
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Recruiting
A Phase 1/2a First-in-Human Study of DB-1419 in Advanced/Metastatic Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/17/2024
Locations: Site USA08-0, Newport Beach, California
Conditions: Solid Tumor, Adult
Mosunetuzumab and Polatuzumab Vedotin for the Treatment of Patients with Relapsed or Refractory Grade 1-3a Follicular Lymphoma
Recruiting
This phase II trial tests how well mosunetuzumab and polatuzumab vedotin works in treating patients with grade 1-3a follicular lymphoma that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Polatuzumab vedotin is a monoclonal antibody, polatuzumab, linked to a toxic agent called vedotin. Polatuzumab attaches to CD79B po... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/17/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3a Follicular Lymphoma, Refractory Grade 1 Follicular Lymphoma, Refractory Grade 2 Follicular Lymphoma, Refractory Grade 3a Follicular Lymphoma
Evaluation of SINGLE PORT (SP) Robotic Technology in Colorectal Surgery
Recruiting
Currently a multiport robotic surgery platform (Intuitive Xi) is widely available and used for colorectal surgery indications. A Single port platform (Intuitive SP) is FDA approved for Head and Neck and Urology but has not been widely used in colorectal surgery. This study seeks to evaluate the safe and effective use of the SP platform for colorectal surgery indications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/17/2024
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Colo-rectal Cancer, Rectal Prolapse, Colostomy Stoma, Colorectal Disorders