California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections
Recruiting
This study will assess patients who have recurrent urinary tract infections and kidney stones which are not blocking the kidney or causing other problems. Currently, we don't know if taking out these stones will improve recurrent urinary tract infections or not. Patients will make a decision with their surgeon about removing or monitoring their stone(s). Whether or not their infections continue with surgery or monitoring will be noted, and this information may help to inform future treatment dec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: University of California San Diego, San Diego, California
Conditions: Urinary Tract Infections, Kidney Stone
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
Recruiting
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.
Gender:
ALL
Ages:
Between 2 months and 17 years
Trial Updated:
07/25/2024
Locations: UC Davis: University of California, Davis, Davis, California
Conditions: Shock, Septic
Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
Recruiting
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting. Optional addendums 1 and 2 included in the protocol are intended to establish comparative groups and focused subgroups within the registry.
Gender:
ALL
Ages:
All
Trial Updated:
07/25/2024
Locations: RANGER & MATCH: University of California - Irvine, Orange, California
Conditions: Peripheral Nerve Injuries
A Study of AMDX-2011P in Participants With Alzheimer's Disease
Recruiting
The purpose of this study is to assess safety, tolerability, plasma pharmacokinetics and biologic activity of a single intravenous dose of AMDX-2011P in participants with Alzheimer's Disease (AD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2024
Locations: Global Research Management, Glendale, California
Conditions: Alzheimer Disease
COMP-4 Supplementation and Brachial Artery FMD
Recruiting
In a young and healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b) act as an anti-clotting product to prevent blood clotting in those vessels. Under physiological stress either due to the development of a disease such as diabetes or simply from aging, the endothelial cells can be impacted and become dysfunctional thereby impairing thei... Read More
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
07/24/2024
Locations: UCLA, Los Angeles, California
Conditions: Aging, Endothelial Dysfunction, Senescence
Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System
Recruiting
The purpose of this prospective cohort study is to assess clinical and quality of life measures as well as to define the severity of adverse effects for the use of the RefleXion system to deliver intensity-modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT), or SCINTIX Biology-guided radiotherapy (BgRT) in standard of care (SOC) use in the treatment of local,loco-regionally advanced, and oligometastatic malignancies. In addition, patient costs and charges will be analyzed to qua... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/24/2024
Locations: City Of Hope, Duarte, California
Conditions: Cancer, Cancer Central Nervous System, Cancer Thoracic, Cancer, Gastrointestinal, Cancer Gynecologic, Cancer, Genito-Urinary, Cancers Lymphatic, Cancer Head and Neck
AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
Recruiting
This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
07/24/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Pain, Appetite Loss, Abuse, Drug
Orthodontic Varnish Microbiology Study
Recruiting
Orthodontic treatment is common in teenagers, which typically involve the attachment of metal brackets to the teeth. These brackets often impede proper oral hygiene, leading to plaque accumulation and the development of white spots lesions (the early stage of cavity development). Our study aims to investigate the efficacy of different commercially available fluoride varnishes to treat these white spot lesions after the completion of orthodontic treatment and evaluate their effect on the oral mic... Read More
Gender:
ALL
Ages:
Between 12 years and 27 years
Trial Updated:
07/24/2024
Locations: UCLA School of Dentistry, Los Angeles, California
Conditions: Dental Caries, Dental Plaque, Dental White Spot
rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)
Recruiting
This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/24/2024
Locations: VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California
Conditions: Gulf War Illness, Depression
Defining Treatment Outcomes and Genetic Architecture in Idiopathic Toe Walking*
Recruiting
To compare and contrast the clinical, gait and parent-reported outcomes following either non-operative (casting) or operative treatment for children with idiopathic toe walking (ITW) and determine whether there are specific genes associated with ITW.
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
07/23/2024
Locations: Shriners Hospitals for Children, Sacramento, California
Conditions: Idiopathic Toe Walking
Probiotic Intervention Study
Recruiting
The current standard of care for obesity is the optimal management of comorbid conditions such as diabetes and hyperlipidemia, and counseling on diet, weight loss, or increased physical activity programs. However, lifestyle, diet, and behavioral interventions may provide between 7-10% reduction in initial weight and even fewer with long-term weight loss. In severely obese patients (BMI\>40 or BMI\>35 with comorbidities), bariatric surgery is also a potential treatment, but there is a high barrie... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/23/2024
Locations: University of California, Los Angeles, California
Conditions: Obesity, Food Addiction
Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy
Recruiting
The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided digitally with the assistance of trained community members without advanced degrees in mental health is an effective and scalable way to address these needs. Despite being effective for improving symptoms and functioning in those who engage in it, uptake a... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/23/2024
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety