California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clinic-Based Financial Coaching and Family Health and Development
Recruiting
This study will examine the impact of clinic-based financial coaching on parent health-related quality of life and child development measures, as well as family social needs for families with young children receiving pediatric care at a primary care practice in the Los Angeles County safety net.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Adam Schickedanz, Los Angeles, California
Conditions: Economic Problems, Development, Child, Quality of Life
Study of Biomarker-Based Treatment of Acute Myeloid Leukemia
Recruiting
This screening and multi-sub-study Phase 1b/2 trial will establish a method for genomic screening followed by assigning and accruing simultaneously to a multi-study "Master Protocol (BAML-16-001-M1)." The specific subtype of acute myeloid leukemia will determine which sub-study, within this protocol, a participant will be assigned to evaluate investigational therapies or combinations with the ultimate goal of advancing new targeted therapies for approval. The study also includes a marker negativ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: UCLA Ronald Reagan Medical Center, Los Angeles, California
Conditions: Previously Untreated Relapsed Refractory Acute Myeloid Leukemia
Stem Cell Therapy for Limbal Stem Cell Deficiency
Recruiting
This phase I study will collect preliminary information on the activity and safety of cLSC. We will investigate the ability to manufacture and transplant cLSC onto the cornea successfully at the time of surgery (feasibility), and have cLSC begin to populate the ocular surface (efficacy) without serious adverse events (safety).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/15/2024
Locations: University of California, Los Angeles, California
Conditions: Limbal Stem-cell Deficiency
Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel
Recruiting
This is a phase Ib study to establish safety of Axi-Cel-2 in patients with Large B Cell Lymphoma (LBCL) who are at high risk of relapse.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/14/2024
Locations: Stanford University, Palo Alto, California
Conditions: Non-Hodgkin Lymphoma, Large B-cell Lymphoma
Talazoparib Monotherapy in PALB2 Mutation Associated Advanced Breast Cancer
Recruiting
This purpose of this study is to test if talazoparib is safe and evaluate its response to advanced breast cancer associated with mutation of gene called PALB.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/14/2024
Locations: Stanford University, Stanford, California
Conditions: Breast Cancer, Advanced Breast Cancer
A Study of Telitacicept for the Treatment of Moderately to Severely Active Systemic Lupus Erythematosus (REMESLE-2)
Recruiting
The purpose of this study is to evaluate the efficacy and safety of telitacicept in the treatment of moderately to severely active SLE.
Gender:
ALL
Ages:
Between 12 years and 70 years
Trial Updated:
09/13/2024
Locations: Hemet site, Hemet, California
Conditions: Systemic Lupus Erythematosus
Safety and Efficacy Trial of HG004 for Leber Congenital Amaurosis Related to Rpe65 Gene Mutations (STAR)
Recruiting
The purpose of the study is to determine whether HG004 as gene therapy is safe and effective for the treatment of Leber Congenital Amaurosis caused by mutations in RPE65 gene.
Gender:
ALL
Ages:
Between 6 years and 50 years
Trial Updated:
09/13/2024
Locations: Research Site, Sacramento, California
Conditions: Leber Congenital Amaurosis, Inherited Retinal Diseases Caused by RPE65 Mutations
A Study to Evaluate RL-007 in the Treatment of Cognitive Impairment Associated With Schizophrenia (CIAS)
Recruiting
The goal of this clinical trial is to evaluate if the investigational drug, RL-007, can improve the cognitive performance of subjects with schizophrenia. The main questions the study aims to answer are: 1. Does RL-007 improve subjects performance in a set of cognitive tasks? 2. Which dose of RL-007 (20 mg or 40 mg) has a larger effect on cognitive performance? 3. How well do subjects tolerate RL-007? In the study, subjects will perform the cognitive tasks at the beginning to get familiar with... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/13/2024
Locations: Recognify Research Site, Culver City, California
Conditions: Cognitive Impairment Associated With Schizophrenia (CIAS), Cognitive Impairment, Schizophrenia
Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics
Recruiting
The purpose of this study is to provide data on the pharmacokinetic (PK), safety, tolerability, efficacy and acceptability of this fixed dose combination (FDC) single tablet 2-drug regimen for virologically suppressed (HIV-1 RNA \[Ribonucleic Acid\] \< 50 \[cells per milliliter\] c/mL) children 6 to less than 12 years of age, weighing at least 25 kilogram (kg).
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
09/13/2024
Locations: GSK Investigational Site, Long Beach, California
Conditions: HIV Infections
Carboplatin or Olaparib for BRcA Deficient Prostate Cancer
Recruiting
This is an unblinded, randomized clinical study comparing the efficacy of DNA damaging chemotherapy using carboplatin, to standard of care therapy for patients who have metastatic castrate resistant prostate cancer. This trial will use olaparib or carboplatin as initial therapy with crossover to the alternate or second-line drug after first progression for patients with tumors containing BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D, or RAD54L inactivating mutations. P... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/13/2024
Locations: VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California
Conditions: Metastatic Castrate Resistant Prostate Cancer, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D, or RAD54L Mutations
Pre-Visit Positive Imagery in Reducing Dental Anxiety
Recruiting
The purpose of this study is to determine whether pre-visit positive imagery has an impact in decreasing dental anxiety and fear in pediatric patients as well as increasing patient cooperation during treatment visits. Patients needing at least 1 composite filling with nitrous and local anesthetic will receive a picture book if they are selected in the experimental group, and no picture book if they are in the control group. Patients will be asked to be fill out a pre-operative survey and post-op... Read More
Gender:
ALL
Ages:
Between 4 years and 6 years
Trial Updated:
09/12/2024
Locations: Herman Ostrow School of Dentistry of USC, Los Angeles, California
Conditions: Dental Anxiety
Selinexor and Backbone Treatments of Multiple Myeloma Patients
Recruiting
This study will independently assess the efficacy and safety of 11 combination therapies in 12 arms, in dose-escalation/-evaluation and expansion phases, for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) and newly diagnosed multiple myeloma (NDMM). The combinations to be evaluated are: * Arm 1: Selinexor + dexamethasone + pomalidomide (SPd); enrollment complete * Arm 2: Selinexor + dexamethasone + bortezomib (SVd); enrollment complete * Arm 3: Selinexor + dexamethas... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Jonnsson Comprehensive Cancer Center / University of Los Angeles, Los Angeles, California
Conditions: Multiple Myeloma