California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
NCT06234605
Recruiting
This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a combination dose expansion. Approximately 80 patients will be enrolled in this study (up to 20 patients will be enrolled into the HC-7366 monotherapy cohort, up to 30 patients into the combination dose escalation, and up to 30 patients into the combin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California San Diego Moores Cancer Center, La Jolla, California
Conditions: Renal Cell Carcinoma
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Efficacy of Ra-223 in PSMA PET Optimally Selected Patients
NCT05924672
Recruiting
This phase II trial studies how well prostate-specific membrane antigen (PSMA) positron emission tomography (PET) scans (in combination with bone scans) work in selecting patients for Ra-223 radiation therapy that have castration-resistant prostate cancer that has spread from where it first started (primary site) to the bones (bone metastasis). Ra-223 is a type of therapy that emits radiation. Radiation gives off energy which can kill tumor cells and other cells that may support the tumor cells.... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Stage IVB Prostate Cancer AJCC v8
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Randomized Trial for cLBP (Gokhale Project)
NCT05657964
Recruiting
The study aims to compare the effectiveness of the Gokhale Method posture therapy for low back pain (LBP) management to standard physical therapy (PT) with posture training. The second aim of this study is to evaluate usability and user adherence of the online/digital intervention through the Gokhale Method Foundation Class (online delivery with smartphone App). The investigator hopes to learn: The effectiveness of the Gokhale Method posture therapy for low back pain management, in comparison... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/20/2024
Locations: Outpatient Surgery Center/Stanford Spine Clinic, Redwood City, California
Conditions: Lower Back Pain Chronic
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Comparing Operative vs Non Operative Treatment for Pilonidal Disease
NCT05439291
Recruiting
The goal is to evaluate whether surgical excision of the pilonidal disease is needed after resolution of the initial symptoms when the patient follows regular hair removal regimen such as laser epilation.
Gender:
ALL
Ages:
8 years and above
Trial Updated:
11/20/2024
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Pilonidal Disease
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Decreasing Emergence Agitation With Personalized Music
NCT05044832
Recruiting
The purpose of the study is to assess the impact of personalized music on emergence agitation (EA), as measured by Pediatric Anesthesia Emergence Delirium scores in pediatric patients recovering from elective procedures under general anesthesia. Personalized music may help to decrease EA in children undergoing elective surgeries under general anesthesia by decreasing perioperative anxiety and minimizing perceived pain. The study has the potential to improve perioperative care by improving safet... Read More
Gender:
ALL
Ages:
Between 3 years and 9 years
Trial Updated:
11/20/2024
Locations: Stanford University, Stanford, California
Conditions: Surgical Procedure, Unspecified
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tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
NCT04925453
Recruiting
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS). Specifically, we will investigate how tDCS combined with cognitive training improves deficits to attention and working memory in Active Duty Service Members with a history of mild traumatic brain injury (TBI). Measures of attention-related brain activity, neurocognitive assessments, and self-re... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
11/20/2024
Locations: Naval Medical Center San Diego, San Diego, California
Conditions: Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment
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Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
NCT04717869
Recruiting
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California
Conditions: Frailty, Sarcopenia
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Impact of the Coronavirus (COVID-19) on Patients With Cancer
NCT04330521
Recruiting
The purpose of this study is to understand the impact of COVID-19 on patients with cancer through a survey.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/20/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Cancer, COVID-19
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Gadolinium Contrast-enhanced Abbreviated MRI (AMRI) Vs. Standard Ultrasound for Hepatocellular Carcinoma (HCC) Surveillance in Patients with Cirrhosis
NCT04288323
Recruiting
This study compares gadolinium contrast-enhanced Abbreviated MRI (AMRI) to standard ultrasound for Hepatocellular Carcinoma (HCC) screening and surveillance in subjects with liver cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Liver Cancer, Liver Cirrhoses, Liver Carcinoma
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Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
NCT04180371
Recruiting
This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. The main goals of this study are to: * Find the recommended dose(s) of BT5528 that can be given safely to participants alone and in combination with nivolumab * Learn more about the side effects of BT5528 * Learn about how effective BT5528 is for the treatment of ovarian cancer, urothelial/bladder cancer, lung cance... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: California Cancer Associates for Research and Excellence, Inc., Encinitas, California
Conditions: Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer, Head and Neck Cancer, Triple Negative Breast Cancer, Gastric/Upper Gastrointestinal Cancer
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Characteristics and Inflammatory Markers in Children with Eosinophilic Esophagitis (EoE)
NCT03980886
Recruiting
Single center observational and specimen banking study for children with eosinophilic esophagitis EoE to gauge natural history and inflammatory markers
Gender:
ALL
Ages:
Between 1 year and 65 years
Trial Updated:
11/20/2024
Locations: Rady Children's Hospital San Diego, San Diego, California
Conditions: Eosinophilic Esophagitis
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FDG PET/CT in Monitoring Very Early Therapy Response in Patients With Glioblastoma
NCT02902757
Recruiting
This pilot clinical trial studies fluordeoxyglucose (fludeoxyglucose) F-18 (FDG) positron emission tomography (PET)/computed tomography (CT) in monitoring very early therapy response in patients with glioblastoma. Diagnostic procedures, such as FDG PET/CT, may help measure a patient's response to earlier treatment. Chemotherapy can induce very rapid changes to the tumor's glucose consumption which can be measured with imaging. FDG PET/CT shortly after the start of therapy may help identify very... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/20/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Glioblastoma
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